α-Helical CRF (12-41) CAS NO.158535-55-8

α-Helical CRF (12-41) is a synthetic 30-amino acid peptide analog of corticotropin-releasing factor (CRF), engineered with a stabilized α-helical secondary structure to function as a potent and selective antagonist of CRF receptors (CRFR1 and CRFR2). It competitively blocks the binding of endogenous CRF, effectively inhibiting the activation of the hypothalamic-pituitary-adrenal (HPA) axis. This makes it an essential research tool for neuroscientists and pharmacologists studying stress physiology, anxiety disorders, and neuroendocrine signaling pathways in preclinical models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	α-Helical CRF (12-41)
CAS NO.	158535-55-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C152H251N43O47S2
Molecular Weight	3497.08g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water, 1% acetic acid, or DMSO
Endotoxin	≤1 EU/mg
Biological Activity	Potent and selective antagonist of CRF receptors (CRFR1 & CRFR2); inhibits CRF-induced ACTH release
Storage Conditions	Store at -20°C, protected from light. Avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide exerts its effects by binding to CRF receptors with high affinity without triggering intracellular signaling, thereby acting as a competitive antagonist. By occupying the receptor binding site, it prevents endogenous CRF from initiating the cAMP/PKA transduction cascade, which normally leads to ACTH and glucocorticoid release. This specific blockade allows researchers to dissect the role of CRF in stress responses and behavioral models without the confounding effects of receptor activation.

2.PRODUCT INDICATIONS

α-Helical CRF (12-41) is indicated for experimental research into stress-related pathologies, including anxiety, depression, and addiction. It is widely used in receptor binding assays, HPA axis modulation studies, and animal models of chronic stress to evaluate the therapeutic potential of CRF pathway inhibition. Researchers also utilize it to validate the efficacy of novel small-molecule CRF antagonists in drug discovery pipelines.

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3.CLINICAL EFFICACY OF PRODUCT

In preclinical studies, this antagonist has demonstrated significant efficacy in attenuating stress-induced ACTH secretion and reversing anxiety-like behaviors in rodent models. It effectively normalizes HPA axis hyperactivity and reduces stress-related feeding and locomotor alterations. While not for human use, its robust performance in vivo makes it a critical reference standard for proof-of-concept studies in neuropsychiatric drug development

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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