Dynorphin B (1-9) CAS NO.126050-26-8

Dynorphin B (1-9) is an endogenous N-terminal neuropeptide fragment that serves as a potent and selective agonist for the kappa-opioid receptor (KOR). It features the core opioid sequence (YGGFL) followed by key residues (RRQF) that enhance its receptor affinity and stability. This peptide is widely used as a critical pharmacological tool in neuroscience research to study pain pathways, stress responses, and addiction mechanisms, offering high purity and reliable performance for both in vitro binding assays and in vivo functional studies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Dynorphin B (1-9)
CAS NO.	126050-26-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C₅₄H₇₈N₁₆O₁₂
Molecular Weight	1115.3g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water, dilute acetic acid, or 1M NaOH
Endotoxin	≤1 EU/mg
Biological Activity	Potent endogenous kappa-opioid receptor (KOR) agonist
Storage Conditions	Store at -20°C, protected from moisture and light
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide exerts its effects by selectively binding to the kappa-opioid receptor (KOR), a Gi/o protein-coupled receptor. This binding inhibits adenylate cyclase, reducing intracellular cAMP levels, and modulates ion channel activity (inhibiting Ca²⁺ channels and activating K⁺ channels), leading to neuronal hyperpolarization. The result is a presynaptic inhibition of neurotransmitter release (e.g., glutamate, dopamine), which underlies its physiological effects on analgesia and mood regulation.

2.PRODUCT INDICATIONS

Dynorphin B (1-9) is indicated for preclinical research applications focused on the central nervous system. It is primarily used in studies investigating neuropathic pain, stress-induced behaviors, depression, and drug addiction. Researchers utilize this peptide to explore KOR's role in modulating the reward pathway and to develop novel non-addictive analgesic and anti-addiction therapies, making it essential for neuropharmacology and psychiatric disorder research.

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3.CLINICAL EFFICACY OF PRODUCT

In experimental models, Dynorphin B (1-9) demonstrates significant KOR-mediated analgesic efficacy in chronic pain and neuropathic pain paradigms. It also shows modulatory effects on affective behaviors, reducing stress responses and drug-seeking behavior in addiction models. However, its efficacy is dose-dependent, as high concentrations can induce dysphoric or aversive effects, highlighting its utility in studying the complex biphasic nature of the dynorphin/KOR system.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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