[Des-Tyr1]- g-Endorphin CAS NO.67810-56-4

[Des-Tyr1]-γ-Endorphin is a naturally occurring neuropeptide fragment derived from β-Endorphin, specifically lacking the N-terminal tyrosine residue (position 1). This unique truncation eliminates its classical opioid analgesic activity while retaining significant neuropsychiatric effects. It is primarily utilized in neuroscience research as a critical tool compound for studying non-opioid pathways related to mental health disorders, stress responses, and neuroendocrine regulation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Des-Tyr1]- g-Endorphin
CAS NO.	67810-56-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C₇₄H₁₂₂N₁₈O₂₅S
Molecular Weight	1747.9g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in 1M acetic acid, DMSO, or deionized water
Endotoxin	≤1 EU/mg
Biological Activity	Modulates dopaminergic and serotonergic neurotransmission; non-opioid neuroleptic effects
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Unlike full-length endorphins, this peptide does not bind significantly to μ-opioid receptors due to the missing Tyr1 moiety. Instead, it exerts its effects through non-opioid mechanisms, primarily by modulating central dopaminergic and serotonergic neurotransmission. It acts as a neuroleptic-like agent, reducing dopamine release in the mesolimbic pathway and influencing GABAergic and glutamatergic systems, which underlies its observed behavioral effects in animal models.

2.PRODUCT INDICATIONS

This product is intended for Research Use Only (RUO), targeting academic and pharmaceutical researchers in psychiatry and neuropharmacology. It is indicated for in vitro binding assays and in vivo studies investigating schizophrenia-like symptoms, depression, addiction, and reward pathways. It serves as an essential reference standard for elucidating the role of endorphin fragments in psychiatric pathophysiology.

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3.CLINICAL EFFICACY OF PRODUCT

While not approved for human therapy, historical experimental data from small-scale human studies and extensive animal research suggest potential efficacy in reducing psychotic symptoms and improving mood-related behaviors. Its neuroleptic-like profile has shown promise in modulating maladaptive behaviors associated with dopamine dysregulation, providing a rationale for its use in preclinical drug discovery.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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