ACTH (34-39) CAS NO.69454-10-0

ACTH (34-39) is a synthetic peptide fragment of adrenocorticotropic hormone (ACTH), specifically comprising residues 34–39. It is widely used in scientific research to investigate melanocortin receptor signaling, adrenal gland function, and skin pigmentation mechanisms. This peptide serves as a critical tool for studying endocrine regulation, metabolic pathways, and receptor-ligand interactions, with applications spanning endocrinology, dermatology, and pharmacology research.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	ACTH (34-39)
CAS NO.	69454-10-0
Appearance	White to off-white lyophilized powder
Molecular Formula	C₃₇H₅₀N₆O₉
Molecular Weight	~722.85 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in 1M acetic acid, DMSO, or deionized water
Endotoxin	≤1 EU/mg
Biological Activity	Activates melanocortin receptors (MC1R, MC2R, MC3R, MC4R, MC5R); modulates adrenal steroidogenesis and pigmentation
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

ACTH (34-39) acts as a ligand for melanocortin receptors (MC1R to MC5R), which are G protein-coupled receptors. Upon binding, it activates downstream signaling cascades—including adenylate cyclase stimulation and cAMP production—leading to diverse physiological responses: MC2R activation promotes cortisol synthesis in the adrenal cortex, while MC1R engagement modulates melanocyte differentiation and melanin production. Its selective activity across melanocortin subtypes enables researchers to dissect receptor-specific roles in metabolism, inflammation, and pigmentation.

2.PRODUCT INDICATIONS

This peptide is indicated for use in in vitro and in vivo research focused on melanocortin receptor biology, adrenal physiology, and skin pigmentation disorders. It is suitable for academic laboratories, pharmaceutical R&D teams, and contract research organizations (CROs) investigating endocrine pathways, drug-target interactions, and potential therapeutic applications for conditions like Addison’s disease, Cushing’s syndrome, or hyperpigmentation. Researchers studying metabolic regulation, immune modulation, or dermatological therapeutics will find it invaluable for mechanistic and preclinical studies.

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3.CLINICAL EFFICACY OF PRODUCT

In preclinical models, ACTH (34-39) demonstrates efficacy in modulating adrenal steroidogenesis, restoring cortisol levels in adrenal insufficiency models, and influencing pigmentation patterns in melanocyte cultures. While not approved for clinical use, its ability to activate melanocortin receptors with high selectivity supports its role in elucidating disease mechanisms and validating therapeutic targets. Data from animal studies highlight its potential to inform drug development for endocrine and dermatological disorders, making it a key asset in translational research pipelines.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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If you have any product requirements, please send an email to:business@huanqiukeji9.com;whatsapp:85270846510