Ac-β-Endorphin (human) CAS NO.80102-04-1

Ac-β-Endorphin (human) is an N-terminally acetylated derivative of the endogenous opioid peptide β-Endorphin. This specific chemical modification enhances the peptide's metabolic stability by protecting it from enzymatic degradation, making it a superior tool for sustained experimental studies compared to the native form. It is widely used in neuroscience and pharmacology research to investigate opioid receptor signaling, pain modulation pathways, and stress responses, strictly for research purposes.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Ac-β-Endorphin (human)
CAS NO.	80102-04-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₆₀H₂₅₃N₃₉O₄₇S
Molecular Weight	3465.0g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in 1M acetic acid, DMSO, or deionized water
Endotoxin	≤1 EU/mg
Biological Activity	Potent agonist for mu and delta opioid receptors; modulates pain perception, stress response, and immune function
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide exerts its effects by binding to and activating G protein-coupled opioid receptors, primarily the mu (MOR) and delta (DOR) subtypes in the central nervous system. Upon receptor engagement, it inhibits adenylate cyclase activity, reduces intracellular cAMP levels, and modulates ion channel conductance, leading to neuronal hyperpolarization. This mechanism underlies its potent ability to inhibit neurotransmitter release and alter pain signal transmission in neural circuits.

2.PRODUCT INDICATIONS

This product is indicated for Research Use Only (RUO), targeting academic researchers, pharmaceutical R&D teams, and CROs focused on neuropharmacology. It serves as a critical reagent in receptor binding assays, functional cAMP accumulation tests, and animal models of analgesia. It is also applied in studies of addiction behavior, emotional regulation, and neuroendocrine functions, providing a stable reference standard for mechanistic investigations.

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3.CLINICAL EFFICACY OF PRODUCT

While not intended for therapeutic use, Ac-β-Endorphin (human) demonstrates high bioactivity in preclinical models. Studies report its efficacy in producing significant, prolonged analgesia in rodent pain models due to its enhanced stability. It effectively modulates stress-induced analgesia and reward pathways in experimental settings, establishing its value as a robust positive control in validating the pharmacological effects of opioid ligands.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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