ACTH (1-24), human CAS NO.16960-16-0

ACTH (1-24), human is a synthetic peptide fragment derived from the full-length adrenocorticotropic hormone, widely utilized in endocrine and metabolic research. It serves as a valuable research tool for studying adrenal gland function, steroidogenesis, and melanocortin receptor signaling pathways. Researchers leverage its ability to stimulate cortisol production without the full physiological complexity of longer ACTH isoforms, making it ideal for in vitro cellular assays and mechanistic studies in both human and animal models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	ACTH (1-24), human
CAS NO.	16960-16-0
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₃₆H₂₁₀N₄₀O₃₁S
Molecular Weight	~2933.5 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in 1M acetic acid, DMSO, or deionized water
Endotoxin	≤1 EU/mg
Biological Activity	Stimulates adrenal cortisol secretion; activates melanocortin receptors (primarily MC2R)
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

ACTH (1-24) binds primarily to the melanocortin type 2 receptor (MC2R) on adrenal cortical cells, activating a G-protein coupled signaling cascade that stimulates adenylate cyclase and increases intracellular cAMP levels. This elevation in cAMP activates protein kinase A, which in turn phosphorylates transcription factors that promote the expression and activity of steroidogenic enzymes, ultimately driving the biosynthesis of cortisol and other adrenal hormones. Its activity is highly specific to MC2R, distinguishing it from other melanocortin receptors involved in pigmentation or appetite regulation.

2.PRODUCT INDICATIONS

This peptide is indicated for use in academic, pharmaceutical, and biotechnology research focused on adrenal physiology, stress response mechanisms, and endocrine disorders such as Cushing’s syndrome or Addison’s disease. It is particularly suited for researchers investigating the molecular basis of hormone regulation, drug development targeting adrenal pathways, and comparative endocrinology across species including humans and model organisms like rodents.

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3.CLINICAL EFFICACY OF PRODUCT

While not approved for direct clinical use in humans, ACTH (1-24) demonstrates high efficacy in preclinical models for evaluating adrenal responsiveness and testing potential therapeutics targeting cortisol regulation. Its consistent activity in stimulating adrenal output makes it a reliable benchmark in pharmacological studies assessing the potency and mechanism of corticosteroid drugs. Researchers rely on its predictable behavior to validate assay systems and generate data applicable to clinical endocrinology and drug discovery pipelines.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: ACTH, Adrenocorticotropic Hormone, Peptide Synthesis, Endocrine Research, Cortisol Stimulation, Melanocortin Receptor, Steroidogenesis, Laboratory Reagent, Biochemical Research, Pharmacological Tool, High Purity Peptide, G Protein Coupled Receptor, Adrenal Gland, Stress Response, Scientific Research, Bioactive Peptide, cAMP Signaling, Hormone Regulation, Preclinical Research, Molecular Biology

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