ACTH (1-4) CAS NO.19405-50-6

ACTH (1-4) is a synthetic tetrapeptide fragment derived from the N-terminal region of adrenocorticotropic hormone, widely utilized in biochemical and pharmacological research to study melanocortin receptor signaling pathways. This high-purity peptide serves as a valuable tool for investigating adrenal cortex function, steroidogenesis regulation, and the anti-inflammatory effects mediated by melanocortin receptors. Researchers in endocrinology, immunology, and neurobiology leverage its specific receptor-binding profile to explore cellular responses and develop novel therapeutic strategies targeting the hypothalamic-pituitary-adrenal axis.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	ACTH (1-4)
CAS NO.	19405-50-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C₂₀H₃₀N₄O₈S
Molecular Weight	~486.6 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in 1M acetic acid, DMSO, or deionized water
Endotoxin	≤1 EU/mg
Biological Activity	Partial agonist activity at melanocortin receptors; modulates adrenal steroidogenesis and exhibits anti-inflammatory properties
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

ACTH (1-4) exerts its biological effects by selectively binding to melanocortin receptors, particularly MC2R, which is predominantly expressed in adrenal cortical cells, as well as other subtypes such as MC1R, MC3R, MC4R, and MC5R. This binding activates G-protein coupled signaling cascades, including adenylate cyclase stimulation, leading to increased intracellular cAMP levels and subsequent activation of protein kinase A. The resultant signaling promotes cholesterol mobilization and conversion into pregnenolone, the rate-limiting step in corticosteroid biosynthesis, while also modulating immune cell function through receptor-mediated anti-inflammatory pathways.

2.PRODUCT INDICATIONS

This peptide is specifically indicated for use in in vitro and in vivo research applications focused on endocrinology, neuroendocrinology, immunology, and metabolic disorders. It is suitable for scientists studying adrenal gland physiology, the pathophysiology of Cushing’s syndrome and Addison’s disease, melanocortin receptor pharmacology, and the development of peptide-based therapeutics targeting inflammation and steroidogenesis. Additionally, it supports investigations into the role of ACTH fragments in stress response mechanisms and their potential modulation of appetite, pigmentation, and energy homeostasis.

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3.CLINICAL EFFICACY OF PRODUCT

Although not intended for direct clinical use, ACTH (1-4) demonstrates significant efficacy in preclinical models as a modulator of adrenal steroidogenesis and anti-inflammatory responses, offering insights into therapeutic targets for adrenal insufficiency and autoimmune diseases. Its ability to activate melanocortin receptors with partial agonism allows researchers to dissect receptor subtype-specific functions, paving the way for the design of selective analogs with improved therapeutic indices. In experimental settings, it consistently induces measurable increases in cortisol secretion and exhibits dose-dependent inhibition of pro-inflammatory cytokine release, validating its utility as a reliable research tool for evaluating melanocortin-based interventions.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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