[D-Val22] Big Endothelin-1 (16-38), human CAS NO.158884-64-1

[D-Val22] Big Endothelin-1 (16-38), human is a synthetic peptide analog derived from the Big ET-1 precursor, engineered with a D-amino acid substitution at position 22 to confer enhanced proteolytic stability. This high-purity research-grade peptide functions as a potent inhibitor of endothelin-converting enzyme (ECE), effectively blocking the maturation of Big ET-1 into active Endothelin-1. It is a critical tool for scientists investigating the endothelin system's role in cardiovascular regulation, neurovascular coupling, and hypertension pathophysiology, providing a stable and specific means to modulate this signaling axis in vitro and in vivo.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[D-Val22] Big Endothelin-1 (16-38), human
CAS NO.	158884-64-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₁₉H₁₈₀N₃₂O₃₃
Molecular Weight	2685.9g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in 1M acetic acid, DMSO, or deionized water
Endotoxin	≤1 EU/mg
Biological Activity	Potent inhibitor of Endothelin Converting Enzyme (ECE); blocks ET-1 production
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide exerts its effects by competitively inhibiting endothelin-converting enzyme (ECE), the key metalloprotease responsible for cleaving the inactive Big ET-1 precursor to produce the potent vasoconstrictor ET-1. The strategic incorporation of D-Valine at position 22 renders the peptide resistant to enzymatic degradation while maintaining high affinity for ECE. By occupying the enzyme's active site, it prevents the conversion of endogenous Big ET-1, thereby reducing the downstream activation of ETA and ETB receptors and the subsequent calcium-mediated signaling that drives vasoconstriction and smooth muscle proliferation.

2.PRODUCT INDICATIONS

This ECE inhibitor is indicated for preclinical research focused on conditions driven by dysregulated endothelin signaling. It is particularly suitable for studies on pulmonary arterial hypertension, chronic kidney disease, cerebral vasospasm, and heart failure models. Researchers in pharmacology and vascular biology utilize this peptide to delineate the specific contributions of ECE activity in disease progression, to develop novel therapeutic inhibitors, and to study receptor-ligand interactions in cell-based assays and animal models without the confounding effects of endogenous ET-1 generation.

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3.CLINICAL EFFICACY OF PRODUCT

While intended for research use only, [D-Val22] Big ET-1 (16-38) has demonstrated significant efficacy in preclinical models as a proof-of-concept agent. Studies have confirmed its ability to suppress ECE activity in vivo, leading to reduced levels of mature ET-1, attenuated vasoconstrictive responses, and improved hemodynamic parameters in hypertensive models. These findings underscore its utility as a robust positive control and a lead compound in the early-stage discovery of ECE-targeting therapeutics for cardiovascular and renal diseases.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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