Ac-[DTrp16] Endothelin-1 (16-21), human CAS NO.143037-33-6

Ac-[DTrp16] Endothelin-1 (16-21), human is a synthetic hexapeptide fragment derived from the C-terminal region of Endothelin-1, engineered with an N-terminal acetyl group and a D-tryptophan substitution at position 16 to enhance metabolic stability and receptor-binding specificity. This research-grade compound is widely utilized as a high-affinity ligand and functional modulator of endothelin receptors (particularly ETA), serving as a critical tool for scientists investigating vascular biology, hypertension mechanisms, and cardiovascular disease pathophysiology in preclinical models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Ac-[DTrp16] Endothelin-1 (16-21), human
CAS NO.	143037-33-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C₄₆H₆₂N₈O₁₀
Molecular Weight	887.0g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in 1M acetic acid, DMSO, or deionized water
Endotoxin	≤1 EU/mg
Biological Activity	High-affinity ligand for ETA receptors; functional endothelin antagonist
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Endothelin 2 exerts its biological effects by binding to two G-protein coupled receptors, ETA and ETB, with high affinity. Activation of ETA receptors on vascular smooth muscle cells triggers a signaling cascade involving phospholipase C and inositol triphosphate, leading to a rapid increase in intracellular calcium and sustained vasoconstriction. Concurrently, its interaction with ETB receptors on endothelial cells can modulate nitric oxide release and mediate peptide clearance, creating a complex regulatory network that influences both vascular contraction and inflammatory responses in research models.

2.PRODUCT INDICATIONS

The peptide exerts its effects by competitively binding to endothelin receptors, primarily the ETA subtype, with high affinity (IC50 ≈ 0.13 µM), thereby acting as a functional antagonist that blocks the binding of full-length Endothelin-1. Its mechanism involves inhibiting Endothelin-1-stimulated signaling pathways, such as arachidonic acid release and calcium mobilization in vascular smooth muscle cells, which are key drivers of vasoconstriction and vascular remodeling, making it a precise pharmacological tool for dissecting receptor-specific responses without inducing full agonist effects.

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3.CLINICAL EFFICACY OF PRODUCT

Although not intended for clinical use, Ac-[DTrp16] Endothelin-1 (16-21) has demonstrated significant efficacy in preclinical settings as a proof-of-concept agent, effectively attenuating Endothelin-1-induced vasoconstriction and reducing vascular hyperreactivity in hypertensive models. Its ability to selectively block ETA receptors while exhibiting improved pharmacokinetic properties due to D-amino acid incorporation validates its utility as a lead compound for the development of novel therapeutics targeting endothelin-driven diseases.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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