isoxanthohumol CAS no.70872-29-6

Isoxanthohumol is a naturally occurring prenylated flavanone primarily derived from the hop plant (Humulus lupulus) and commonly found in beer, supplied as a high-purity reference standard or research-grade powder for laboratory experimentation. It serves as a crucial phytochemical tool for researchers investigating natural product chemistry, especially regarding the biotransformation of hop compounds into potent phytoestrogens like 8-prenylnaringenin within the human gut microbiome. This product is specifically designed for use by pharmacologists, biochemists, and food scientists focusing on flavonoid metabolism, antioxidant capacity, and the potential health impacts of dietary polyphenols, providing a reliable compound for in vitro assays and analytical method development.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	isoxanthohumol
CAS NO.	70872-29-6
Appearance	Yellow to pale yellow crystalline powder or amorphous solid
Molecular Formula	C21H22O5
Molecular Weight	354.40 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in DMSO, methanol, ethanol; slightly soluble in water
Endotoxin	≤10 EU/mg
Biological Activity	Potent phytoestrogen, antioxidant, and anti-inflammatory activity; modulates estrogen receptors and NF-κB signaling
Storage Conditions	Store at – 20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The biological activity of isoxanthohumol is executed through multiple molecular pathways, most notably by modulating signal transduction cascades related to inflammation and cell survival, such as the NF-κB, JAK/STAT, and MAPK routes, leading to the downregulation of pro-inflammatory cytokines and adhesion molecules. It exerts antiproliferative effects on various cancer cell lines by inducing cell cycle arrest and promoting apoptosis through mitochondrial dysfunction and the generation of reactive oxygen species (ROS), while also interfering with angiogenic processes by inhibiting VEGF receptor signaling and capillary tube formation. Additionally, it functions as a modulator of xenobiotic-metabolizing enzymes, particularly inhibiting specific cytochrome P450 isoforms (like CYP1A2) which affects carcinogen activation, and interacts with cellular lipid metabolism pathways including AMPK/PPARα and PI3K/AKT to reduce fat accumulation and improve metabolic profiles.

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2.PRODUCT INDICATIONS

This product is indicated for non-clinical research applications targeting professionals in oncology, cardiometabolic science, microbiology, and dermatology who are studying cancer biology, obesity, hyperlipidemia, viral infections, and vascular health. It is highly suitable for scientists exploring the chemopreventive properties of hop-derived compounds against hormone-dependent cancers (breast, prostate, ovarian) and colorectal carcinogenesis, as well as researchers investigating antiviral therapies against herpes simplex virus (HSV) and bovine viral diarrhea virus (BVDV). Furthermore, it is applicable for nutritionists and gut microbiota researchers examining the bidirectional relationship between dietary polyphenols and intestinal flora, and for formulators requiring a high-quality standard to quantify flavonoid content in botanical extracts or fermented beverages via HPLC and mass spectrometry.

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3.CLINICAL EFFICACY OF PRODUCT

As a raw material intended strictly for laboratory research and not as a finished pharmaceutical drug, isoxanthohumol does not possess approved clinical efficacy for human treatment, yet it demonstrates significant bioactive potential in extensive preclinical in vitro and in vivo studies. Experimental data from cell culture and animal models confirm its capacity to inhibit tumor cell proliferation, reduce neointimal hyperplasia in vascular injury models, alleviate symptoms of chemically induced colitis, and improve lipid metabolism and insulin sensitivity in obese mice. These research findings validate its strong pharmacological activity at the cellular and systemic levels, establishing it as a valuable lead compound for drug discovery and a key reference point for understanding the biological effects of dietary hop constituents, rather than serving as a direct therapeutic intervention for patients.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

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Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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We can also customize packaging according to customer needs.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: Flavonoid, Prenylflavonoid, Hop Compound, Phytoestrogen, Antioxidant, Anti-inflammatory, Anticancer, Research Chemical, Natural Product, Gut Microbiome, Phytochemical, Apoptosis Inducer.

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