Nε-(Carboxymethyl)lysine CAS NO.5746-04-3

Nε-(Carboxymethyl)lysine (CML) is a high-purity biochemical reagent widely recognized as a primary advanced glycation end product (AGE) formed through the oxidative modification of proteins, serving as a critical standard for researchers investigating protein glycation, oxidative stress, and the Maillard reaction. This stable, white crystalline compound is essential for laboratories focusing on aging, metabolic disorders, and food chemistry, offering reliable consistency for analytical method development such as HPLC or mass spectrometry. Its unique properties make it an indispensable tool for scientists studying the structural changes in proteins exposed to high temperatures or oxidative environments, as well as for those developing assays to quantify AGE levels in biological fluids and processed food items.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Nε-(Carboxymethyl)lysine
CAS NO.	5746-04-3
Appearance	White to off-white powder or crystalline solid
Molecular Formula	C8H16N2O4
Molecular Weight	204.22 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water, methanol, and dimethyl sulfoxide (DMSO); insoluble in non-polar organic solvents
Endotoxin	< 1.0 EU/mg
Biological Activity	Acts as a major advanced glycation end-product (AGE) involved in protein modification, oxidative stress pathways, and the Maillard reaction; activates RAGE signaling
Storage Conditions	Store at -20°C in a dry, dark place; avoid repeated freeze-thaw cycles to maintain stability
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

CML exerts its biological effects primarily through the activation of the Receptor for Advanced Glycation End products (RAGE), a transmembrane protein that, upon binding CML, triggers a cascade of intracellular signaling pathways including the MAPK (ERK1/2) and NF-κB routes. This interaction leads to the generation of reactive oxygen species (ROS) and the subsequent induction of pro-inflammatory cytokines, effectively mimicking the pathological conditions observed in chronic hyperglycemia and oxidative stress. Additionally, CML can interact with other scavenger receptors like CD36 to promote lipid uptake in macrophages, while its ability to form cross-links with structural proteins like collagen alters tissue stiffness and function, providing a molecular basis for studying cellular senescence and dysfunction in various disease models.

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2.PRODUCT INDICATIONS

This product is indicated strictly for in vitro research and analytical applications, targeting scientific professionals and institutions engaged in biochemical, pharmaceutical, and food science studies rather than therapeutic use. It is particularly suited for researchers modeling diabetic complications, cardiovascular diseases, and neurodegenerative conditions where AGE accumulation is a hallmark, as well as for food technologists assessing the impact of thermal processing and storage on nutritional quality. Furthermore, it serves as a vital calibration standard for immunoassays and chromatography, enabling accurate quantification of CML adducts in plasma, tissue homogenates, and food extracts for academic and industrial quality control purposes.

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3.CLINICAL EFFICACY OF PRODUCT

While CML itself is not a therapeutic agent and thus lacks clinical efficacy in a treatment sense, its utility as a research chemical is highly effective in validating experimental models of disease, such as successfully inducing markers of vascular calcification, hepatocarcinogenesis, and osteosarcoma progression in controlled cellular and animal studies. The compound's reliability in reproducing pathophysiological AGE-RAGE signaling allows researchers to efficiently test the potency of potential inhibitors or antioxidants aimed at mitigating AGE-related damage, thereby proving instrumental in preclinical efficacy assessments of new drug candidates targeting diabetes, atherosclerosis, and aging-related pathologies.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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