Procyanidin B1 CAS NO.20315-25-7

Procyanidin B1 is a naturally occurring dimeric flavonoid, primarily sourced from commonly consumed fruits such as grapes, apples, and berries, as well as traditional medicinal plants like grape seeds and cinnamon. As a high-purity reference standard or active natural ingredient, it is characterized by its white to light yellow powder form and stable physicochemical properties when stored properly. This compound is widely utilized in scientific research due to its distinct polyphenolic structure, serving as a critical tool for phytochemical analysis, nutritional studies, and pharmacological screening. Its natural abundance and well-defined profile make it a valuable subject for researchers exploring plant-derived bioactive compounds, as well as for industries developing functional foods, dietary supplements, and cosmeceutical formulations aimed at health-conscious consumers.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Procyanidin B1
CAS NO.	20315-25-7
Appearance	White to off-white powder
Molecular Formula	C30H26O12
Molecular Weight	578.52 g/mol
Purity (RP-HPLC)	≥98.0%
Solubility	Soluble in water, methanol, DMSO, and ethanol; insoluble in chloroform and ether
Endotoxin	≤0.1 EU/mg
Biological Activity	Potent antioxidant, anti-inflammatory, cardiovascular protective effects, skin anti-aging, and capillary strengthening properties
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The primary biological action of Procyanidin B1 is driven by its potent antioxidant capacity and its ability to modulate key cellular signaling pathways related to inflammation and stress response. It functions by directly scavenging free radicals and reactive oxygen species, thereby mitigating oxidative stress at the cellular level, while also interacting with specific molecular targets such as the TLR4/MD-2 complex to inhibit the downstream activation of pro-inflammatory cytokines like TNF-α and IL-6. Furthermore, it exerts regulatory effects on critical enzymatic activities and ion channels, including the inhibition of COX-2, direct interaction with Caspase proteins to influence apoptotic pathways, and specific blockage of the Kv10.1 potassium channel which is linked to tumor cell proliferation. Through these multi-target interactions, it effectively suppresses the phosphorylation of proteins in the MAPK and NF-κB signaling cascades, leading to a comprehensive anti-inflammatory and cytoprotective cellular environment.

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2.PRODUCT INDICATIONS

This product is indicated primarily for laboratory research, pharmaceutical development, and quality control applications within the food, supplement, and cosmetic industries. It is extensively used as a primary reference standard for the identification, quantification, and purity assessment of procyanidin content in botanical extracts, fruit juices, and finished nutraceutical products via chromatographic methods. In pharmacological and biomedical research settings, it is indicated for in vitro and in vivo studies investigating anti-inflammatory therapeutics, neuroprotective agents against amyloid-beta toxicity, cardiovascular health benefits, and potential anti-cancer drug leads targeting liver or colon carcinoma models. Additionally, it serves as a vital reagent for food scientists examining the bioavailability and metabolic fate of dietary flavonoids, as well as for formulators seeking to validate the functional efficacy of antioxidant-rich ingredients in skincare and health supplement products.

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3.CLINICAL EFFICACY OF PRODUCT

Although Procyanidin B1 is currently restricted to preclinical and research-use contexts rather than approved as a standalone clinical drug, extensive in vitro and animal model studies have demonstrated significant efficacy in several therapeutic areas. Research indicates that it effectively protects neuronal cells from death induced by amyloid-beta oligomers at micromolar concentrations, suggesting strong potential for further study in neurodegenerative disorder models. In oncology-related preclinical trials, it has shown the ability to suppress the growth of hepatoma and colon cancer xenografts by inducing cancer cell apoptosis and cell cycle arrest, achieving notable tumor growth inhibition rates without observed toxicity to normal metabolic functions. Furthermore, its efficacy in reducing LPS-induced inflammatory responses highlights its promise as a lead compound for developing novel anti-inflammatory agents, providing a solid scientific foundation for ongoing pharmacological exploration and the standardization of botanical therapeutic products.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: Procyanidin B1, Dimeric Flavonoid, Polyphenol, Natural Product, Antioxidant, Anti-inflammatory, Reference Standard, Grape Seed Extract, Neuroprotection, TLR4 Inhibitor.

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