Cecropin B CAS NO.80451-05-4

Cecropin B is a highly purified, cationic antimicrobial peptide (AMP) originally isolated from the hemolymph of the Cecropia moth, consisting of 35 to 37 amino acid residues that adopt a characteristic amphipathic alpha-helical structure essential for its biological function. Supplied as a lyophilized white to off-white powder, this research-grade peptide serves as a critical standard for scientists investigating innate immune defenses, membrane biophysics, and novel strategies to combat drug-resistant pathogens. Its well-defined sequence and potent, broad-spectrum bioactivity make it an indispensable tool for pharmaceutical R&D, microbiology laboratories, and academic institutions focused on infectious disease research, biotechnology development, and the exploration of peptide-based therapeutics for both human and veterinary applications.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Cecropin B
CAS NO.	80451-05-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C176H302N52O41S1
Molecular Weight	3734.73 g/mol
Purity (RP-HPLC)	≥98.0%
Solubility	Soluble in water, dilute acetic acid; insoluble in common organic solvents like ethanol, methanol, and acetone
Endotoxin	≤0.5 EU/mg
Biological Activity	Potent antibacterial activity against Gram-negative bacteria, antiparasitic effects, anticancer cell proliferation, immunomodulatory functions
Storage Conditions	Store at -20°C in a dry, dark, and well-sealed container; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Cecropin B exerts its primary biological effects through a distinctive membrane-disruption mechanism initiated by electrostatic attraction to the negatively charged phospholipids prevalent in microbial cell membranes, such as lipopolysaccharides in Gram-negative bacteria and teichoic acids in Gram-positive species. Upon binding to the membrane surface, the peptide undergoes a conformational shift to an ordered alpha-helix, inserting its hydrophobic regions into the lipid bilayer while maintaining hydrophilic contacts with the aqueous environment. At sufficient concentrations, these inserted peptides aggregate to form toroidal pores or a destabilizing "carpet-like" layer, which increases membrane permeability, dissipates the proton-motive force, causes uncontrolled ion and macromolecule efflux, and ultimately leads to osmotic lysis of the target cell. This physical mode of action, which targets the fundamental integrity of the microbial envelope rather than specific intracellular enzymes or metabolic pathways, allows Cecropin B to rapidly kill a wide range of microbes while presenting a significantly higher intrinsic barrier to the development of classical microbial resistance.

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2.PRODUCT INDICATIONS

This product is specifically indicated for laboratory research, preclinical studies, and quality control applications within pharmaceutical, biotechnological, and academic settings dedicated to antimicrobial discovery and membrane biology. It serves as a primary reference peptide for determining minimum inhibitory concentrations (MICs) against diverse bacterial pathogens, including ESKAPE organisms and multidrug-resistant clinical isolates, utilizing standardized assays such as broth microdilution and radial diffusion methods. Researchers employ Cecropin B to investigate the structure-activity relationships of amphipathic peptides, to study the biophysical interactions between cationic peptides and lipid bilayers using techniques like NMR and fluorescence spectroscopy, and to evaluate its potential as a lead compound or synergistic agent in combination therapies with conventional antibiotics. Additionally, it is indicated for cell-based assays examining its cytotoxic effects on various cancer cell lines, anti-biofilm evaluations, immunomodulatory studies assessing its impact on cytokine expression, and as a template in synthetic biology for designing novel, protease-resistant antimicrobial peptides.

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3.CLINICAL EFFICACY OF PRODUCT

While Cecropin B is currently designated strictly for research use and has not received regulatory approval as a clinical therapeutic agent, extensive in vitro and animal model studies have established its remarkable efficacy across multiple domains of infectious disease and oncology research. Laboratory evaluations consistently demonstrate potent bactericidal activity against a broad spectrum of clinically relevant pathogens, including Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus, with rapid killing kinetics often observed at micromolar concentrations. In murine models of wound infection, topical administration of Cecropin B has shown significant efficacy in reducing bacterial loads of Pseudomonas aeruginosa, improving healing parameters, and decreasing mortality rates. Furthermore, in rat models of Gram-negative septic shock, intraperitoneal administration of Cecropin B, either alone or in synergy with beta-lactam antibiotics, has demonstrated the ability to reduce animal mortality, decrease bacterial counts in peritoneal fluid, and significantly lower plasma levels of endotoxin and pro-inflammatory cytokines like TNF-α, providing a robust preclinical foundation for its continued investigation as a multifunctional lead peptide in drug discovery pipelines.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: Cecropin B, Antimicrobial Peptide, AMP, Cationic Peptide, Membrane Active Peptide, Broad-Spectrum Antibacterial, Anti-Biofilm, Cecropia Moth Peptide.

If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85294920037