Cecropin P1 CAS NO.125667-96-1

Cecropin P1 is a highly purified, cationic antimicrobial peptide (AMP) originally isolated from the intestinal tissues of pigs, consisting of 31 amino acid residues that form a distinctive amphipathic alpha-helical structure upon interacting with lipid membranes. Supplied as a lyophilized white to off-white powder, this research-grade peptide is a vital tool for scientists studying innate immunity, membrane biophysics, and novel strategies to combat multidrug-resistant pathogens. Its well-defined sequence and potent, broad-spectrum bioactivity make it an essential reference standard for pharmaceutical R&D, microbiology laboratories, and academic institutions focused on infectious disease research, veterinary medicine, and the exploration of peptide-based therapeutics for both human and animal health applications.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Cecropin P1
CAS NO.	125667-96-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C147H253N45O43
Molecular Weight	3338.91 g/mol
Purity (RP-HPLC)	≥99.0%
Solubility	Soluble in water, dilute acetic acid; insoluble in common organic solvents like ethanol, methanol, and acetone
Endotoxin	≤0.5 EU/mg
Biological Activity	Potent antibacterial activity against Gram-negative bacteria, antiparasitic effects, anticancer cell proliferation, immunomodulatory functions
Storage Conditions	Store at -20°C in a dry, dark, and well-sealed container; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1kit

1.MECHANISM OF ACTION

Cecropin P1 exerts its primary biological effects through a distinctive "carpet-like" membrane-disruption mechanism, which begins with the electrostatic attraction of its cationic residues to the negatively charged phospholipids prevalent in microbial cell membranes, such as lipopolysaccharides in Gram-negative bacteria. Upon binding to the membrane surface, the peptide adopts an ordered alpha-helical conformation and aligns parallel to the lipid bilayer, where accumulating peptide monomers destabilize the packing of the phospholipid molecules without forming discrete transmembrane pores. At sufficient concentrations, this accumulation leads to thinning and eventual disintegration of the membrane structure, causing increased permeability, dissipation of the proton-motive force, uncontrolled ion flux, and rapid osmotic lysis of the target cell. This physical mode of action, which targets the fundamental integrity of the microbial envelope rather than specific intracellular enzymes, allows Cecropin P1 to rapidly kill a wide range of microbes while presenting a significantly higher barrier to the development of classical microbial resistance compared to traditional antibiotics.

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2.PRODUCT INDICATIONS

This product is specifically indicated for laboratory research, preclinical studies, and quality control applications within pharmaceutical, biotechnological, and academic settings dedicated to antimicrobial discovery, virology, and membrane biology. It serves as a primary reference peptide for determining minimum inhibitory concentrations (MICs) against diverse bacterial pathogens, including ESKAPE organisms and multidrug-resistant clinical isolates, utilizing standardized assays such as broth microdilution and radial diffusion methods. Researchers employ Cecropin P1 to investigate the structure-activity relationships of amphipathic peptides, to study the biophysical interactions between cationic peptides and lipid bilayers using techniques like NMR and fluorescence spectroscopy, and to evaluate its potential as a lead compound or synergistic agent in combination therapies with conventional antibiotics. Additionally, it is indicated for virology assays examining its ability to block viral attachment and replication (such as PRRSV), anti-biofilm evaluations, immunomodulatory studies, and as a template in synthetic biology for designing novel, protease-resistant antimicrobial and antiviral peptides for veterinary and agricultural uses.

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3.CLINICAL EFFICACY OF PRODUCT

While Cecropin P1 is currently designated strictly for research use and has not received regulatory approval as a clinical therapeutic agent, extensive in vitro and animal model studies have established its remarkable efficacy across multiple domains of infectious disease, virology, and veterinary research. Laboratory evaluations consistently demonstrate potent bactericidal activity against a broad spectrum of clinically relevant pathogens, including Escherichia coli, Salmonella typhimurium, Haemophilus parasuis, and Staphylococcus aureus, with rapid killing kinetics often observed at micromolar concentrations. In murine models of septic shock, intraperitoneal administration of Cecropin P1 has shown significant efficacy in preventing bacterial growth, reducing endotoxemia, and improving survival rates. Furthermore, in veterinary-relevant virology research, Cecropin P1 effectively inhibits the infection and replication of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) by blocking viral attachment to host cells and impairing virus-induced apoptosis, providing a robust preclinical foundation for its continued investigation as a multifunctional lead peptide in drug discovery pipelines targeting both bacterial sepsis and viral infections.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: Cecropin P1, Antimicrobial Peptide, AMP, Cationic Peptide, Membrane Active Peptide, Broad-Spectrum Antibacterial, Antiviral, Porcine Peptide.

If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85294920037