CRAMP (mouse) CAS NO.376364-36-2

CRAMP (mouse), also known as Cathelicidin-Related Antimicrobial Peptide, is the sole identified murine member of the cathelicidin family, serving as the ortholog to the human LL-37 peptide and supplied as a high-purity lyophilized powder for advanced immunological and microbiological research. This 34 to 38-amino acid residue peptide is a fundamental tool for scientists studying innate immune defenses, host-microbe interactions, and the translational modeling of human cathelicidin functions in a rodent context. Its well-characterized structure and multifaceted biological profile make it an essential reference standard for pharmaceutical R&D, academic laboratories, and biotechnology firms focused on infectious disease mechanisms, inflammatory disorders, and the development of novel host-defense peptide-based therapeutics.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	CRAMP (mouse)
CAS NO.	376364-36-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C178H302N50O46
Molecular Weight	3878.67 g/mol
Purity (RP-HPLC)	≥99.0%
Solubility	Soluble in water, dilute acetic acid, or PBS (pH 7.4); insoluble in common organic solvents like ethanol and methanol
Endotoxin	≤0.5 EU/mg
Biological Activity	Exhibits potent bactericidal activity against Gram-positive and Gram-negative bacteria, promotes chemotaxis of immune cells, accelerates wound healing, and modulates inflammatory responses
Storage Conditions	Store at -20°C in a dry, dark, and well-sealed container; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1kit

1.MECHANISM OF ACTION

The primary mechanism of CRAMP (mouse) involves a dual-action strategy combining direct microbial membrane disruption with complex immunomodulatory signaling through specific G-protein-coupled receptors. Initially, the cationic peptide is electrostatically attracted to the negatively charged phospholipids of microbial membranes, where it adopts an amphipathic alpha-helical conformation and inserts into the lipid bilayer to form toroidal pores or a carpet-like structure, leading to rapid depolarization, uncontrolled ion flux, and osmotic lysis of target bacteria, fungi, or enveloped viruses. Concurrently, CRAMP interacts with host cell receptors such as Fpr2 (Formyl Peptide Receptor 2) on immune and epithelial cells, triggering intracellular calcium mobilization, MAPK pathway activation, and the subsequent chemotaxis of neutrophils, monocytes, and macrophages to sites of infection or injury. This receptor-mediated activity also enables the peptide to neutralize bacterial endotoxins like LPS, modulate cytokine production (including TNF-α and IL-6), and promote downstream processes such as angiogenesis and re-epithelialization during tissue repair.

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2.PRODUCT INDICATIONS

This product is specifically indicated for in vitro laboratory research, preclinical animal model studies, and analytical applications within immunological, microbiological, and dermatological research settings. It serves as a critical reagent for evaluating broad-spectrum antimicrobial potency against multidrug-resistant bacterial pathogens and biofilm-forming strains using standardized MIC and radial diffusion assays, as well as for investigating peptide-lipid membrane interactions via biophysical techniques like NMR and circular dichroism. Researchers utilize CRAMP (mouse) to explore its role in maintaining gut mucosal homeostasis, suppressing intestinal inflammation (such as in DSS-induced colitis models), and regulating the gut microbiota balance in murine systems. Additionally, it is indicated for cell-based assays examining its chemotactic properties, wound-healing potential, and its function as a mechanistic proxy for human LL-37 in studies related to innate immunity, sepsis, chronic inflammatory diseases, and the development of engineered peptide antibiotics.

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3.CLINICAL EFFICACY OF PRODUCT

Although CRAMP (mouse) is strictly designated for research use and is not a clinical therapeutic agent, extensive in vitro and murine in vivo studies have demonstrated its significant efficacy in modeling host defense and resolving inflammatory pathologies. Laboratory assays confirm its potent, rapid bactericidal activity against a wide array of clinically relevant pathogens, including Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and various fungi, often at low micromolar concentrations without facilitating classic resistance development. In murine models of Gram-negative bacterial pneumonia and septic shock, the administration or endogenous expression of CRAMP has proven effective in reducing lung bacterial burdens, lowering endotoxin levels, improving survival rates, and attenuating excessive pro-inflammatory cytokine storms. Furthermore, studies utilizing CRAMP-deficient (Cnlp-/-) mice highlight its crucial efficacy in protecting against DSS-induced ulcerative colitis by supporting colon crypt development, enhancing mucus production, and preventing inflammation-associated carcinogenesis, thereby providing a robust preclinical framework for understanding cathelicidin-based protection in mucosal immunity and tissue homeostasis.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags:CRAMP (mouse), Cathelicidin, Antimicrobial Peptide, AMP, LL-37 Analog, Innate Immunity, Immunomodulatory, Murine Peptide.

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