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Corticostatin I (rabbit) CAS NO.134090-73-6

Corticostatin I (rabbit), also identified as neutrophil defensin NP-3a, is a highly purified, cationic 34-amino acid peptide characterized by its high arginine and cysteine content and stabilized by three pairs of disulfide bonds, supplied as a lyophilized white powder for specialized endocrine and immunological research. Originally isolated from rabbit fetal and adult lung tissues as well as peritoneal neutrophils, this peptide serves as a critical research standard for scientists investigating the complex regulatory mechanisms of the hypothalamic-pituitary-adrenal (HPA) axis and innate immune responses. Its well-defined structure and multifunctional biological profile make it an essential reagent for pharmaceutical R&D, academic laboratories, and biotechnology firms focused on stress physiology, neuroendocrinology, antimicrobial discovery, and the development of novel immunomodulatory therapeutics.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Corticostatin I (rabbit)
CAS NO.	134090-73-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C163H259N63O44S6
Molecular Weight	3997.64 g/mol
Purity (RP-HPLC)	≥99.0%
Solubility	Soluble in water, dilute acetic acid, or PBS (pH 7.4); insoluble in common organic solvents like ethanol and methanol
Endotoxin	≤0.5 EU/mg
Biological Activity	Potent inhibitor of corticosterone release from the adrenal glands, exhibits moderate antimicrobial activity against certain bacterial species, and possesses immunomodulatory properties
Storage Conditions	Store at -20°C in a dry, dark, and well-sealed container; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1kit

1.MECHANISM OF ACTION

The primary biological mechanism of Corticostatin I (rabbit) involves the competitive inhibition of adrenocorticotropic hormone (ACTH) binding to its specific receptors on adrenal cortical cells, specifically interfering with the address recognition site (amino acids 14-18) of the ACTH molecule to prevent the subsequent stimulation of corticosteroid synthesis and cAMP accumulation. Beyond this endocrine modulation, the peptide exerts direct antimicrobial effects by disrupting the integrity of microbial cell membranes through its cationic and amphipathic properties, leading to rapid membrane depolarization and osmotic lysis of target pathogens. Additionally, it functions as a potent immunomodulator by stimulating L-type calcium channels, inducing chemotaxis of monocytes, triggering mast cell degranulation to release histamine, and significantly enhancing the phagocytic activity of macrophages, thereby bridging innate immune defense with neuroendocrine regulation at the cellular signaling level.

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2.PRODUCT INDICATIONS

This product is specifically indicated for in vitro laboratory research, cell-based assays, and biochemical applications within endocrinological, immunological, and microbiological research settings. It serves as a primary reference peptide for evaluating the inhibition of ACTH-stimulated steroidogenesis in rat adrenal cell suspensions, utilizing standardized bioassays to determine its potency with an established ID50 of approximately 25 nM. Researchers employ Corticostatin I (rabbit) to investigate the structure-activity relationships of defensins and corticostatins, to study the bidirectional communication between the nervous, endocrine, and immune systems, and to assess its broad-spectrum microbicidal activity against various bacterial and fungal strains using radial diffusion and minimal inhibitory concentration assays. Furthermore, it is indicated for cell adhesion and migration studies, calcium flux assays in immune cells, and as a mechanistic tool for exploring novel anti-inflammatory pathways and host-defense strategies in both basic science and preclinical drug discovery pipelines.

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3.CLINICAL EFFICACY OF PRODUCT

Although Corticostatin I (rabbit) is strictly designated for research use and is not a clinical therapeutic agent, extensive in vitro and animal model studies have demonstrated its significant efficacy in modulating adrenal function, enhancing immune surveillance, and combating microbial infections. Laboratory evaluations confirm its status as the most potent member of the corticostatin family, capable of completely inhibiting ACTH-stimulated corticosterone production at nanomolar concentrations without affecting basal steroidogenesis or angiotensin II-stimulated pathways, highlighting its high specificity for the melanocortin system. In cellular models, it effectively enhances the phagocytic index of peritoneal macrophages in a dose-dependent manner and exhibits potent microbicidal activity against a range of microorganisms, validating its dual role as both a hormonal regulator and an effector of innate immunity. These preclinical findings provide a robust scientific framework for understanding the physiological balance of stress responses and immune activation, guiding further research into defensin-based therapeutics and HPA axis modulation.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags:Corticostatin I (rabbit), Defensin NP-3a, Anti-ACTH Peptide, Neutrophil Peptide, HPA Axis, Immunomodulatory, Antimicrobial Peptide, Endocrinology Research.

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