Angiotensin A CAS NO.34273-12-6

Angiotensin A, also widely recognized in the scientific community as Angiotensin I or Angiotensin-(1-10), is a highly purified decapeptide hormone supplied as a lyophilized white powder, serving as the essential precursor substrate within the Renin-Angiotensin System (RAS). This research-grade peptide is a fundamental tool for pharmacologists, biochemists, and cardiovascular researchers investigating blood pressure regulation, hypertension mechanisms, and renal physiology. Its well-defined sequence and high stability make it indispensable for laboratories conducting enzyme kinetics, drug screening assays, and preclinical studies aimed at developing novel therapeutics for cardiovascular and kidney-related disorders, providing a reliable standard for both in vitro and in vivo experimental models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Angiotensin A
CAS NO.	34273-12-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C56H78N16O13
Molecular Weight	1183.34 g/mol
Purity (RP-HPLC)	≥99.0%
Solubility	Soluble in water, dilute acetic acid, or PBS (pH 7.4); insoluble in common organic solvents like ethanol and methanol
Endotoxin	≤0.5 EU/mg
Biological Activity	Potent inhibitor of corticosterone release from the adrenal glands, exhibits moderate antimicrobial activity against certain bacterial species, and possesses immunomodulatory properties
Storage Conditions	Store at -20°C in a dry, dark, and well-sealed container; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1kit

1.MECHANISM OF ACTION

The primary mechanism of Angiotensin A involves its role as a biologically inactive prohormone that is enzymatically converted into the potent vasoactive peptide, Angiotensin II, primarily through the catalytic action of Angiotensin-Converting Enzyme (ACE). Upon entering the circulation or local tissue sites, Angiotensin A undergoes specific cleavage at its C-terminal dipeptide (His-Leu) by ACE, predominantly in the pulmonary endothelium, to yield the octapeptide Angiotensin II. Once generated, Angiotensin II then binds to specific G-protein-coupled receptors, mainly the AT1 receptor, triggering a cascade of intracellular signaling events including the stimulation of phospholipase C, increased intracellular calcium release, and the activation of protein kinase C. This downstream mechanism ultimately leads to physiological outcomes such as vasoconstriction, aldosterone synthesis, sympathetic nervous system activation, and cellular proliferation, positioning Angiotensin A as the critical initiating substrate for these regulatory pathways.

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2.PRODUCT INDICATIONS

This product is specifically indicated for laboratory research, pharmaceutical drug discovery, and biochemical assay development focused on the Renin-Angiotensin-Aldosterone System (RAAS) and associated cardiovascular pathways. It serves as the primary substrate for ACE activity assays, allowing researchers to quantify the conversion rate of Angiotensin I to Angiotensin II and to evaluate the inhibitory potency of candidate ACE inhibitor drugs in high-throughput screening platforms. Additionally, it is indicated for use in cell-based studies to examine receptor binding dynamics, signal transduction profiles, and the downstream effects of RAS activation when co-incubated with converting enzymes. Researchers also utilize Angiotensin A to induce experimental hypertension in animal models, to calibrate mass spectrometry and HPLC methods for peptide quantification in biological fluids, and as a reference standard for the quality control and identification of angiotensin-related metabolites in nutraceutical and pharmaceutical formulations.

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3.CLINICAL EFFICACY OF PRODUCT

Although Angiotensin A itself is not a clinical therapeutic agent and is strictly designated for research purposes, extensive biochemical and pharmacological studies have validated its absolute efficacy as a precursor for generating Angiotensin II, the central effector of the RAAS. In controlled in vitro environments, Angiotensin A demonstrates complete and rapid conversion to Angiotensin II in the presence of ACE, with kinetic studies establishing its Michaelis-Menten constant (Km) as a standard benchmark for evaluating enzyme efficiency and drug interference. Preclinical animal studies utilizing infused Angiotensin A reliably replicate hypertensive states, successfully modeling the physiological impacts of RAAS overactivation, including elevated blood pressure, cardiac remodeling, and renal tubular changes, which are fundamental for testing antihypertensive interventions. Furthermore, its consistent performance as a substrate in diagnostic assay kits and its role in validating the efficacy of blockbuster medications like Lisinopril and Losartan underscore its critical efficacy as a research reagent in bridging basic peptide biology to clinical cardiovascular therapeutics.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags:Angiotensin A, Angiotensin I, Decapeptide, Renin-Angiotensin System, RAS, ACE Substrate, Hypertension Research, Cardiovascular Peptide.

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