Lys-(Ala3)-Bradykinin CAS NO.103545-18-2

Lys-(Ala3)-Bradykinin, also referred to as KR-10, is a synthetic decapeptide analog of the endogenous vasoactive hormone Bradykinin, featuring a specific N-terminal lysine extension and a proline-to-alanine substitution at the third position, supplied as a high-purity lyophilized white powder for advanced pharmacological research. This structurally modified peptide serves as a critical tool for scientists investigating the kallikrein-kinin system, offering altered receptor binding dynamics and enhanced metabolic stability compared to the native nonapeptide. Its well-defined sequence and unique conformational properties make it an essential reference standard for pharmaceutical R&D, biochemical laboratories, and academic institutions focused on cardiovascular physiology, inflammatory signaling pathways, nociception, and the structure-activity relationship studies of G-protein-coupled receptor ligands.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Lys-(Ala3)-Bradykinin
CAS NO.	103545-18-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C54H83N17O12
Molecular Weight	1162.37 g/mol
Purity (RP-HPLC)	≥99.0%
Solubility	Soluble in water or dilute acetic acid; insoluble in common organic solvents
Endotoxin	≤0.5 EU/mg
Biological Activity	Potent B1 receptor agonist; exhibits selective agonistic activity with higher stability and affinity for the B1 receptor compared to native Bradykinin; used to study inflammatory pain, cardiovascular regulation, and the functional role of the kinin system in pathological conditions
Storage Conditions	Store at -20°C in a dry, dark, and well-sealed container; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1kit

1.MECHANISM OF ACTION

The primary biological mechanism of Lys-(Ala3)-Bradykinin involves its specific interaction with bradykinin receptors, predominantly the constitutively expressed B2 subtype, where it acts as a selective agonist to trigger intracellular signal transduction cascades. Upon binding to the B2 receptor on the cell surface, the peptide induces a conformational change that activates coupled Gq/11 proteins, leading to the dissociation of alpha and beta-gamma subunits and the subsequent stimulation of phospholipase C (PLC). This enzymatic activation catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 binds to receptors on the endoplasmic reticulum to mediate the release of intracellular calcium stores, while DAG activates protein kinase C (PKC), and the combined elevation of cytoplasmic calcium and PKC activity drives downstream effects including the synthesis and release of nitric oxide, prostacyclin, and various pro-inflammatory mediators, ultimately resulting in vasodilation, increased vascular permeability, smooth muscle contraction, and pain signal transmission.

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2.PRODUCT INDICATIONS

This product is specifically indicated for in vitro laboratory research, receptor binding assays, and preclinical pharmacological studies centered on the kininergic system and related G-protein-coupled receptor signaling. It serves as a primary pharmacological tool for evaluating the binding affinity, selectivity, and functional potency of bradykinin B2 receptor agonists, often utilized in competitive radioligand binding assays and calcium flux assays using transfected cell lines or native tissues. Researchers employ Lys-(Ala3)-Bradykinin to elucidate the structure-activity relationships of bradykinin analogs, to investigate the differential signaling profiles between B1 and B2 receptor activation, and to study the enzymatic degradation pathways mediated by kinases such as ACE and neutral endopeptidase. Furthermore, it is indicated for use in isolated tissue bath experiments to assess vascular reactivity, for inflammation and edema models to evaluate changes in vascular permeability, and as a standardized reagent in drug discovery pipelines aiming to develop novel modulators of the kallikrein-kinin system for cardiovascular and inflammatory disorders.

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3.CLINICAL EFFICACY OF PRODUCT

Although Lys-(Ala3)-Bradykinin is strictly designated for research use and is not a clinical therapeutic agent, extensive in vitro pharmacological and preclinical studies have validated its significance as a stable and selective B2 receptor probe with distinct kinetic properties. Laboratory evaluations confirm that the Ala3 substitution and N-terminal lysine extension confer altered receptor binding characteristics compared to native Bradykinin, with studies indicating a specific affinity profile and metabolic resistance that prolongs its interaction time with target receptors in biological assays. Preclinical tissue-based experiments demonstrate that this analog effectively induces B2-mediated biological responses, such as the relaxation of pre-contracted vascular smooth muscle strips and the stimulation of prostaglandin synthesis in endothelial cells, often exhibiting a modified potency and duration of action relative to the native peptide. These findings underscore the efficacy of Lys-(Ala3)-Bradykinin as a reliable research reagent for dissecting the nuanced pharmacology of the kinin system, validating assay conditions for receptor deorphanization, and providing a structural template for the rational design of next-generation kinin receptor modulators in drug discovery.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags:Lys-(Ala3)-Bradykinin, KR-10, Bradykinin Analog, Decapeptide, B2 Receptor Agonist, Kallikrein-Kinin System, GPCR Ligand, Cardiovascular Research.

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