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Met-Lys-Bradykinin CAS NO.550-19-6

Met-Lys-Bradykinin, also known as Methionyl-Lysyl-Bradykinin or MK-Bradykinin, is a synthetic undecapeptide and a structurally defined analog of the endogenous vasoactive hormone Bradykinin, supplied as a high-purity lyophilized powder for specialized pharmacological and biochemical research. This peptide features an N-terminal extension of methionine and lysine residues attached to the Bradykinin sequence, making it a vital tool for scientists investigating the kallikrein-kinin system, G-protein-coupled receptor (GPCR) signaling, and peptide metabolism. Its well-characterized properties and specific receptor interactions make it an essential reference standard for pharmaceutical R&D, academic laboratories, and biotechnology firms focused on cardiovascular physiology, inflammatory pathways, nociception, and the development of novel kinin-based therapeutics.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Met-Lys-Bradykinin
CAS NO.	550-19-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C61H94N18O13S
Molecular Weight	1319.61 g/mol
Purity (RP-HPLC)	≥99.0%
Solubility	Soluble in water, dilute acetic acid; insoluble in common organic solvents
Endotoxin	≤1.0 EU/mg
Biological Activity	Acts as a bradykinin analog and B2 receptor agonist; involved in vasodilation, inflammation, pain signaling, and vascular permeability; can be metabolically processed by ACE and specific proteases
Storage Conditions	Store at -20°C in a dry, dark, and well-sealed container; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1kit

1.MECHANISM OF ACTION

The primary biological mechanism of Met-Lys-Bradykinin involves its specific interaction with bradykinin receptors, predominantly the constitutively expressed B2 subtype, where it acts as an agonist to trigger intracellular signal transduction cascades. Upon binding to the B2 receptor on endothelial and smooth muscle cells, the peptide induces a conformational change that activates coupled Gq/11 proteins, leading to the stimulation of phospholipase C (PLC) and the subsequent hydrolysis of PIP2 into IP3 and DAG. This signaling cascade results in the release of intracellular calcium stores, the activation of protein kinase C (PKC), and the downstream synthesis of nitric oxide and prostacyclin, ultimately mediating physiological effects such as vasodilation, increased vascular permeability, smooth muscle contraction, and the transmission of pain signals. While it binds to these receptors with slightly lower affinity compared to native Bradykinin, its unique N-terminal structure influences its metabolic stability and interaction with peptidases like angiotensin-converting enzyme (ACE) and aminopeptidase P.

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2.PRODUCT INDICATIONS

This product is specifically indicated for in vitro laboratory research, receptor binding assays, and preclinical pharmacological studies centered on the kininergic system and related GPCR signaling pathways. It serves as a primary pharmacological tool for evaluating the binding affinity, selectivity, and functional potency of bradykinin B2 receptor agonists, often utilized in competitive radioligand binding assays, calcium flux assays using transfected cell lines, and isolated tissue bath experiments. Researchers employ Met-Lys-Bradykinin to elucidate the structure-activity relationships of bradykinin analogs, to investigate the enzymatic degradation pathways mediated by various kininases and carboxypeptidases, and to study its potential role in stimulating cellular processes such as fibroblast proliferation and DNA synthesis. Furthermore, it is indicated for use in inflammation and edema models to evaluate changes in vascular permeability, for pain research examining nociceptive signaling, and as a standardized reagent in drug discovery pipelines aiming to develop novel modulators of the kallikrein-kinin system for cardiovascular and inflammatory disorders.

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3.CLINICAL EFFICACY OF PRODUCT

Although Met-Lys-Bradykinin is strictly designated for research use and is not a clinical therapeutic agent, extensive in vitro pharmacological and preclinical studies have validated its significance as a stable and functionally active B2 receptor probe. Laboratory evaluations confirm that this analog effectively induces B2-mediated biological responses, such as the relaxation of pre-contracted vascular smooth muscle strips, the stimulation of prostaglandin synthesis in endothelial cells, and the induction of vascular permeability, often exhibiting a modified potency and duration of action relative to native Bradykinin. Preclinical research demonstrates that it can be proteolytically processed from kininogen precursors by specific enzymes, such as neutrophil-derived proteinase 3 and certain pathogen-secreted aspartic proteases, highlighting its relevance in host-pathogen interaction studies and inflammatory microenvironments. These findings underscore the efficacy of Met-Lys-Bradykinin as a reliable research reagent for dissecting the nuanced pharmacology of the kinin system, validating assay conditions for receptor ligand screening, and providing a structural template for understanding kinin peptide processing in both health and disease.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags:Met-Lys-Bradykinin, MK-Bradykinin, Methionyl-Lysyl-Bradykinin, Bradykinin Analog, Undecapeptide, B2 Receptor Agonist, Kallikrein-Kinin System, GPCR Ligand.

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