SennosideA CAS NO.81-27-6

Sennoside A is a high-purity dimeric anthraquinone glycoside, naturally derived from the leaves of Senna alexandrina(senna) and Rheum officinale(rhubarb), supplied as a yellow crystalline powder primarily intended for pharmaceutical formulation, herbal standardization, and pharmacological research. This potent bioactive compound serves as the principal reference standard for quantifying senna extracts and is a critical raw material for manufacturers producing stimulant laxatives, bowel cleansing preparations, and certain traditional medicine remedies. It is specifically catered to pharmaceutical companies, quality control laboratories, and nutraceutical producers requiring a reliable, water-soluble (in alkaline conditions) active ingredient that meets stringent pharmacopeial standards for consistency, safety, and efficacy in digestive health applications.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Sennoside A
CAS NO.	81-27-6
Appearance	Yellow to orange-yellow amorphous powder or crystals
Molecular Formula	C42H38O20
Molecular Weight	862.74 g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in methanol, DMSO, pyridine; slightly soluble in water; insoluble in chloroform or ether
Endotoxin	< 10 EU/mg
Biological Activity	Potent antagonist at μ, δ, and κ opioid receptors
Storage Conditions	Store at 2-8°C or room temperature, protected from light and moisture. Keep container tightly sealed.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Endomorphin-2 exerts its effects by selectively binding to μ-opioid receptors with high affinity, thereby activating G-protein coupled signaling pathways that inhibit adenylate cyclase and reduce cAMP production. This action leads to the hyperpolarization of neurons and inhibition of neurotransmitter release, effectively blocking pain signal transmission in both the central and peripheral nervous systems. Its mechanism is distinct in its ability to induce the release of other endogenous opioids like dynorphin A, contributing to its complex analgesic profile in preclinical models.

2.PRODUCT INDICATIONS

This product is strictly indicated for research use in biochemical and pharmacological studies, including receptor binding assays, signal transduction research, and in vitro functional characterization of μ-opioid receptor activity. It is particularly valuable for scientists investigating spinal cord-mediated analgesia, neuropathic pain mechanisms, and opioid receptor pharmacology. The peptide is also employed in the screening and development of new analgesic drugs and in studies exploring the physiological roles of endogenous opioid systems.

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3.CLINICAL EFFICACY OF PRODUCT

As a research biochemical, β-Endorphin (1-27) is not intended for human therapeutic use. Its efficacy is demonstrated in preclinical research settings, where it has been shown to effectively reverse or prevent analgesia induced by full-length β-endorphin and other opioid agonists in animal models, providing robust data on the modulation of nociceptive thresholds and the physiological role of endogenous opioid fragments.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: Sennoside A, Senna Glycoside, Stimulant Laxative, Anthraquinone, Bowel Preparation, Constipation Relief, Rhein Anthrone Precursor, Herbal Extract Standard, Pharmaceutical API, Digestive Health, Colon Cleanser, Prodrug Laxative, Senna Alexandrina, Rheum Officinale

If you have any product requirements, please send an email to:consult@huanqiukeji9.com;whatsapp:+34 686532411