SennosideB CAS NO.128-57-4

Sennoside B is a high-purity dimeric anthraquinone glycoside, naturally derived from the leaves and pods of senna plants (such as Senna alexandrinaand Cassia angustifolia), supplied as a pale yellow crystalline powder primarily intended for pharmaceutical manufacturing, herbal standardization, and pharmacological research. This potent bioactive compound serves as a critical reference standard for quantifying senna extracts and is a key active pharmaceutical ingredient (API) for producers formulating stimulant laxatives, bowel cleansing kits, and certain traditional herbal remedies. It is specifically catered to pharmaceutical companies, quality control laboratories, and nutraceutical manufacturers requiring a reliable, water-soluble (in alkaline conditions) ingredient that meets stringent pharmacopeial standards for consistency, safety, and efficacy in digestive health and constipation management applications.

consult@huanqiukeji9.com

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Sennoside B
CAS NO.	128-57-4
Appearance	Light yellow to yellow crystalline powder or prismatic crystals
Molecular Formula	C42H38O20
Molecular Weight	862.74 g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in DMSO (slightly, heated), NaHCO₃ solution; slightly soluble in Methanol; insoluble in water, Chloroform, Ether
Endotoxin	< 10 EU/mg
Biological Activity	Dianthrone glycoside and stimulant laxative; metabolized by colonic bacteria to active anthrones that increase colonic motility and fluid secretion. Also exhibits anti-PDGF, anti-TNF-α, and gastroprotective properties.
Storage Conditions	Store at 2-8°C or -20°C, protected from light and moisture. Keep container tightly sealed.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Sennoside B functions as a prodrug that remains largely unabsorbed in the upper gastrointestinal tract until it reaches the colon, where it undergoes hydrolysis by indigenous anaerobic bacteria (such as Eubacteriumspp.) to yield the active metabolite, rhein anthrone. This active aglycone subsequently stimulates the myenteric plexus of the enteric nervous system, which enhances the peristaltic contractions of the colonic smooth muscle and accelerates the transit time of fecal matter through the large intestine. Simultaneously, it inhibits the Na+/K+-ATPase pump and alters chloride ion transport in the colonic mucosal cells, reducing the absorption of water and electrolytes (particularly sodium and chloride) back into the bloodstream, which increases the volume and softens the consistency of the stool, thereby facilitating defecation through combined prokinetic and secretory mechanisms.

2.PRODUCT INDICATIONS

Sennoside B is indicated for the short-term relief of occasional constipation in adults and children, as well as for the routine bowel preparation required prior to diagnostic procedures such as colonoscopies, sigmoidoscopies, or radiological examinations of the colon. It is widely utilized by formulators developing over-the-counter (OTC) laxative tablets, syrups, and suppositories aimed at patients suffering from acute constipation, hemorrhoids, or those requiring postoperative bowel regulation following anesthesiology or surgical interventions. Additionally, it serves as a vital analytical benchmark for phytochemists and regulatory scientists validating the potency of senna-based teas, dietary supplements, and botanical drugs, ensuring that commercial products deliver the labeled dosage of anthranoid glycosides to the end consumer, while also being investigated in non-clinical research for potential anti-platelet-derived growth factor (PDGF) and neuroprotective activities.

upload/attachment/image/202605/13/17786651554a5be14e30e8e9701e65d36a98ee3734_local.png

3.CLINICAL EFFICACY OF PRODUCT

Sennoside B has demonstrated high efficacy in producing a bowel movement typically within 6 to 12 hours of oral administration, with success rates in relieving occasional constipation often comparable to or exceeding those of bulk-forming laxatives and osmotic agents like polyethylene glycol. Studies confirm its effectiveness in achieving adequate bowel cleansing for colonoscopy when used in split-dosing regimens, often showing superior patient tolerance and compliance profiles compared to full-dose saline purgatives due to reduced nausea and vomiting. Furthermore, research indicates that standard therapeutic doses effectively increase stool frequency and improve stool consistency without significant systemic absorption, establishing its role as a reliable, locally acting agent, although clinical guidelines emphasize limiting its use to short durations to mitigate the risk of electrolyte imbalance or laxative dependency.

upload/attachment/image/202605/13/1778665161f74a6502c26a1e79e20f5fa86aebd884_local.png

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

upload/attachment/image/202603/30/17748488791d02f82103a700e61eeafa024a96f6ff_local.jpg

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

upload/attachment/image/202601/20/1768872924be74a0641f7ddbf20e541c97f2066c5c_local.jpg

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: Sennoside B, Senna Glycoside, Stimulant Laxative, Anthraquinone, Bowel Preparation, Constipation Relief, Rhein Anthrone Precursor, Herbal Extract Standard, Pharmaceutical API, Digestive Health, Colon Cleanser, Prodrug Laxative, Senna Alexandrina, Cassia Angustifolia

If you have any product requirements, please send an email to:consult@huanqiukeji9.com;whatsapp:+34 686532411