Ailanthone CAS NO.981-15-7
TECHNICAL SPECIFICATIONS
Item | Specification |
|---|---|
Product Name | Ailanthone |
CAS NO. | 981-15-7 |
Appearance | Yellow to yellow-brown amorphous powder |
Molecular Formula | C₂₀H₂₄O₇ |
Molecular Weight | 376.40 g/mol |
Amino Acid Sequence | Not applicable |
Purity (RP-HPLC) | ≥98.0% |
Solubility | Soluble in DMSO, methanol, and ethanol; insoluble in water |
Endotoxin | < 1 EU/mg |
Biological Activity | Potent and specific inhibitor of eukaryotic translation initiation factor 4A (eIF4A); exhibits significant anti-tumor, antiviral, and anti-inflammatory activities by suppressing oncogenic protein synthesis and viral replication |
Storage Conditions | Store at -20°C, protected from light and moisture |
Stock Location | USA / Germany / China (optional, based on actual stock) |
MOQ | 1 mg |
1.Mechanism of Action
Ailanthone exerts its potent pharmacological effects primarily by functioning as a highly specific and irreversible inhibitor of the DEAD-box RNA helicase eukaryotic initiation factor 4A (eIF4A), which is essential for cap-dependent translation of mRNAs, particularly those involved in cell proliferation and survival, thereby effectively blocking protein synthesis and inducing apoptosis in cancer cells while also interfering with viral replication processes.
2.Product Indications
This high-purity compound is specifically indicated for use in oncology and antiviral research, serving as a critical chemical probe for studying the eIF4A-mediated translation initiation mechanism, and is suitable for developing novel therapeutic agents targeting aggressive tumors and viral infections, as well as for investigating its anti-inflammatory applications in preclinical studies.
3.Clinical Efficacy of Product
In preclinical in vitro and in vivo models, ailanthone has demonstrated significant efficacy in inhibiting the growth of various human cancer cell lines, including leukemia, lung, and liver cancer, by inducing programmed cell death and suppressing tumor angiogenesis, while also showing robust activity against RNA viruses, positioning it as a promising lead compound for future clinical trials in cancer therapy and antiviral treatment.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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