3′-O-Acetylhamaudol CAS NO.30358-88-4

3'-O-Acetylhamaudol is a high-purity natural pyranochromenone derivative, specifically isolated from the roots of Angelica japonica(Japanese angelica), supplied as a white to off-white crystalline powder primarily intended for pharmacological research, natural product chemistry, and oncology drug discovery. This bioactive acetoxy-substituted compound serves as a critical reference standard for phytochemical analysis and a vital tool for scientists investigating tumor growth inhibition, angiogenic signaling, and gut-associated lymphoid tissue modulation. It is specifically targeted at pharmaceutical R&D departments, cancer biologists, and natural product chemists who require a reliable, high-quality reagent to study anti-tumor mechanisms, validate analytical methods for Angelicaspecies extracts, and explore novel immunomodulatory leads derived from medicinal plants.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	3'-O-Acetylhamaudol
CAS NO.	30358-88-4
Appearance	Colorless or pale yellow oily liquid / amorphous solid
Molecular Formula	C17H18O6
Molecular Weight	318.32 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in ethanol, methanol, ethyl acetate; insoluble in water
Endotoxin	≤10 EU/mg
Biological Activity	Furanocoumarin derivative; exhibits platelet anti-aggregatory activity, calcium channel blocking effects, and potential anti-proliferative properties.
Storage Conditions	Store at -20°C, protected from light and moisture. Keep container tightly sealed.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

3'-O-Acetylhamaudol exerts its distinctive anti-tumor effects through a dual mechanistic pathway that does not rely on direct cytotoxicity against cancer cells but rather targets the tumor microenvironment and host immune system. Primarily, it acts as a potent anti-angiogenic agent by inhibiting Vascular Endothelial Growth Factor (VEGF)-induced phosphorylation of VEGFR-2 in human umbilical vein endothelial cells (HUVECs), thereby disrupting the VEGF signaling cascade essential for new blood vessel formation that feeds solid tumors. Secondly, it modulates the host immune response by activating intestinal intraepithelial lymphocytes (IELs)—particularly CD8+ T cells and NK cells—in the spleen and small intestine of tumor-bearing subjects, which in turn enhances the secretion of anti-tumor cytokines such as interferon-gamma (IFN-γ) and interleukin-2 (IL-2) to suppress malignancy progression at the systemic level.

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2.PRODUCT INDICATIONS

3'-O-Acetylhumaodol is indicated strictly for non-clinical, in vitro, and in vivo research applications focused on oncology, angiogenesis, and mucosal immunology, where it is utilized to study the prevention of tumor-induced blood vessel sprouting and the regulation of gut-associated immune cell populations. Researchers employ this compound to investigate potential adjuvant therapies for solid tumors (such as colon carcinoma models) that are resistant to conventional chemotherapy, as well as to explore the intricate cross-talk between endothelial cell function and intestinal lymphocyte activation in immunosuppressive microenvironments. Additionally, it serves as a primary pharmaceutical reference standard for analytical chemists developing HPLC and mass spectrometry methods to quantify bioactive pyranochromenones in Angelica japonicaand related Apiaceaefamily botanical extracts intended for pharmacological validation and quality control.

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3.CLINICAL EFFICACY OF PRODUCT

3'-O-Acetylhamaudol has demonstrated significant efficacy in preclinical animal models, where oral administration (at doses of 25 and 50 mg/kg, twice daily) effectively inhibited the tumor growth of colon 26 carcinoma in mice without exerting direct toxic effects on the cancer cells themselves. Experimental data confirms that while the compound does not alter VEGF production or Hypoxia-Inducible Factor-1alpha (HIF-1α) expression within the tumor cells, it successfully blocks VEGF-induced endothelial cell tube formation and migratory capabilities at micromolar concentrations (10 μM). These findings establish its robust capacity to suppress solid tumor expansion predominantly by starving the neoplasm of its vascular supply and simultaneously bolstering the host's intestinal immune surveillance, marking it as a compound with unique dual-action therapeutic potential for ongoing anticancer research.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

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Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

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Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: 3'-O-Acetylhamaudol, Pyranochromenone, Angelica Japonica, Anti-angiogenic, Antitumor, VEGFR-2 Inhibitor, Intestinal Intraepithelial Lymphocyte, Natural Product, Immunomodulator, Oncology Research, VEGF Signaling, Hamaudol Acetate, Phytochemical, Research Standard

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