Polyphyllin VII CAS NO.68124-04-9，

Polyphyllin VII is a high-purity steroidal saponin, primarily isolated from the rhizomes of Paris polyphylla(Chinese herbal medicine "Qi Ye Yi Zhi Hua"), supplied as an off-white to white crystalline powder intended for advanced pharmacological research, natural product standardization, and anticancer drug discovery. This bioactive furostanol saponin serves as a critical reference standard for HPLC and MS analysis of Parisspecies extracts and a vital tool for scientists investigating multi-targeted anticancer mechanisms, including apoptosis, autophagy, and ferroptosis. It is specifically catered to pharmaceutical R&D laboratories, oncologists, and phytochemical researchers who require a reliable, highly soluble (in DMSO, methanol, and chloroform) reagent to study tumor cell cycle arrest, chemoresistance reversal, and the quantification of bioactive saponins in traditional medicine quality control.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Polyphyllin VII
CAS NO.	68124-04-9
Appearance	White to off-white crystalline powder
Molecular Formula	C51H82O21
Molecular Weight	1031.18 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water, DMSO; insoluble in ethanol, acetone, chloroform
Endotoxin	≤10 EU/mg
Biological Activity	Steroidal saponin; induces apoptosis, autophagy, and ferroptosis in various cancer cells; inhibits metastasis via GSK-3β/β-catenin and EGFR-MEK/ERK pathways; exhibits anti-inflammatory and hepatoprotective effects.
Storage Conditions	Store at -20°C, protected from light and moisture. Keep container tightly sealed.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Polyphyllin VII exerts its distinct anticancer and anti-inflammatory effects through multiple sophisticated molecular pathways, most notably by binding to and inducing the degradation of Moesin (MSN) via the ubiquitin-proteasome system, which subsequently impairs the Wnt/β-catenin signaling pathway to inhibit cancer cell growth and overcome drug resistance. Additionally, it triggers programmed cell death by activating the mitochondrial apoptotic cascade (modulating Bcl-2/Bax ratios and caspase-3/9 activation), initiating autophagic flux, and inducing ferroptosis through the inhibition of TOPK (T-lymphokine-activated killer cell-originated protein kinase) to promote ULK1-dependent autophagy. The compound also suppresses neuroinflammation and ischemia-reperfusion injury by modulating the Treg/Th17 immune cell balance via mTORC1 signaling suppression and reduces pulmonary hypertension by upregulating miR-205-5p to target the β-catenin pathway, demonstrating a versatile multi-target engagement at the cellular level.

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2.PRODUCT INDICATIONS

Polyphyllin VII is indicated strictly for non-clinical, in vitro, and in vivo research applications spanning oncology, neurobiology, cardiology, and microbiology, where it is utilized to study therapeutic strategies against various solid tumors such as lung, breast, colorectal, liver, and cervical cancers. Researchers employ this compound to investigate the reversal of multidrug resistance (e.g., overcoming bortezomib resistance in multiple myeloma or P-glycoprotein-mediated resistance in leukemia and breast cancer) and to explore neuroprotective agents against cerebral ischemia-reperfusion injury and hypertrophic scar formation. Furthermore, it serves as a primary pharmaceutical and phytochemical reference standard for analytical chemists developing chromatographic methods to quantify steroidal saponins in Paris polyphyllaand related botanicals, catering to professionals in natural product drug discovery, traditional Chinese medicine (TCM) standardization, and preclinical evaluation of apoptosis/autophagy-inducing agents.

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3.CLINICAL EFFICACY OF PRODUCT

Polyphyllin VII has demonstrated significant efficacy in extensive preclinical evaluations, showing potent cytotoxic activity with low micromolar IC50 values (often < 2-10 µM) against a broad spectrum of cancer cell lines, including ARP1, MM.1S, HepG2, MCF-7/ADR, and lung CTC-TJH-01 cells, frequently outperforming other polyphyllin family members. In vivo xenograft studies confirm its robust tumor growth inhibition capabilities, significantly reducing tumor volume and weight in murine models of multiple myeloma, breast cancer, gastric cancer, and lung metastasis, often achieving 60% or greater suppression rates at doses ranging from 3 to 15 mg/kg without severe systemic toxicity. Moreover, the compound effectively induces anoikis in circulating tumor cells to inhibit lung metastasis, ameliorates infarct volume and neuroinflammation in MCAO stroke models, and exerts antifungal activity against Candida albicans(MIC 4-8 µg/mL), establishing its strong multi-dimensional therapeutic potential in oxidative stress, cancer, and inflammatory pathology models.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: Polyphyllin VII, Paris Saponin VII, Steroidal Saponin, Anticancer, Apoptosis Inducer, Autophagy Activator, Ferroptosis Inducer, Moesin Inhibitor, TOPK Inhibitor, Natural Product, Phytochemical, Research Standard, Traditional Chinese Medicine, Multidrug Resistance Reversal

If you have any product requirements, please send an email to:consult@huanqiukeji9.com;whatsapp:+34 686532411