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Swertiamarin CAS NO.17388-39-5

Swertiamarin is a high-purity secoiridoid glycoside naturally isolated from medicinal plants of the Swertiaand Enicostemmagenera (such as Swertia chinensisand Enicostemma littorale), supplied as an off-white to light yellow crystalline powder primarily intended for pharmacological research, natural product standardization, and drug discovery. This bioactive bitter compound serves as a critical reference standard for HPLC and MS analysis of gentianaceous herbs and a vital tool for scientists investigating anti-diabetic, hepatoprotective, and anti-inflammatory mechanisms. It is specifically targeted at pharmaceutical R&D laboratories, nutraceutical manufacturers, and phytochemical researchers who require a reliable, water-soluble (and soluble in DMSO/methanol) reagent to study glucose homeostasis, oxidative stress modulation, and the quantification of bioactive iridoids in traditional medicines like "Qinjiao" or "Chirata".

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Swertiamarin
CAS NO.	17388-39-5
Appearance	White to off-white crystalline powder (flake-like crystals)
Molecular Formula	C16H22O10
Molecular Weight	374.34 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in DMSO, Methanol, Ethanol, Water; insoluble in Chloroform, Ether
Endotoxin	≤10 EU/mg
Biological Activity	Secoiridoid glycoside with potent anti-inflammatory, hepatoprotective, hypoglycemic, and antioxidant activities; regulates NF-κB, JAK2/STAT3, and Nrf2/HO-1 signaling pathways.
Storage Conditions	Store at -20°C, protected from light and moisture. Keep container tightly sealed.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Swertiamarin exerts its diverse biological effects by orchestrating multiple signaling cascades, most notably activating the Nrf2/HO-1 antioxidant pathway to upregulate endogenous defensive enzymes and scavenge reactive oxygen species (ROS) that cause cellular damage. It potently suppresses chronic inflammation by inhibiting the phosphorylation of IκBα and the subsequent translocation of NF-κB, while also modulating the JAK2/STAT3 and MAPK pathways to downregulate pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. Additionally, the compound improves metabolic regulation by activating the AMPK signaling axis and PPAR-γ pathways to enhance insulin sensitivity, promote adipose tissue browning via the ADRB3/UCP1 axis, and inhibit key carbohydrate-digesting enzymes (α-amylase and α-glucosidase), thereby interfering with glucose absorption and lipid synthesis at the molecular level.

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2.PRODUCT INDICATIONS

Swertiamarin is indicated for non-clinical research applications spanning endocrinology, hepatology, gastroenterology, and immunology, where it is utilized to study therapeutic strategies for Type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and hyperlipidemia. Researchers employ this compound to investigate hepatoprotective agents against drug-induced liver injury (e.g., CCl4 or ANIT models) and gallstone/cholestasis management via FXR receptor activation, as well as to explore anti-arthritic mechanisms involving osteoclast differentiation and bone erosion prevention. Furthermore, it serves as a primary pharmaceutical reference standard for analytical chemists developing chromatographic methods to quantify secoiridoid glycosides in Swertiaspecies extracts, catering to professionals in traditional medicine quality control, functional food development, and preclinical drug discovery focusing on natural leads for metabolic and inflammatory disorders.

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3.CLINICAL EFFICACY OF PRODUCT

Swertiamarin has demonstrated significant efficacy in extensive preclinical evaluations, showing a potent ability to lower blood glucose levels and improve insulin sensitivity in streptozotocin-induced diabetic rodents, often performing comparably to standard drugs like metformin by restoring GLUT4 translocation and adiponectin expression. In hepatotoxicity models, administration of the compound (100–200 mg/kg) significantly reduced serum markers of liver damage (ALT, AST, ALP), restored antioxidant glutathione levels, and attenuated hepatic lipid accumulation and fibrosis by modulating SREBP-1c and CYP7A1 expression. Moreover, it effectively ameliorates ulcerative colitis in murine models by repairing intestinal mucosal barriers through YAP-mediated Wnt/Notch signaling, inhibits carrageenan-induced paw edema often surpassing diclofenac sodium, and reduces atherosclerotic indices and triglyceride concentrations in hypercholesterolemic rats, establishing its robust multitarget therapeutic potential in metabolic and inflammatory pathology models.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: Swertiamarin, Secoiridoid Glycoside, Iridoid, Anti-diabetic, Hepatoprotective, Anti-inflammatory, Antioxidant, Nrf2 Activator, AMPK Activator, Natural Product, Phytochemical, Research Standard, Swertia Chinensis, Enicostemma Littorale

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