Dactylorhin A CAS NO.256459-34-4

Dactylorhin A is a high-purity phenylethanol glycoside and a succinate derivative ester, naturally isolated from the rhizomes of medicinal orchids such as Gymnadenia conopsea(Fragrant Orchid) and Bletilla striata(Common Bletilla), supplied as a white to off-white crystalline powder primarily intended for pharmacological research, natural product standardization, and anti-inflammatory screening. This complex glycosidic compound serves as a critical reference standard for HPLC and MS analysis of orchidaceae extracts and a vital tool for scientists investigating nitric oxide (NO) modulation, oxidative stress, and plant-derived bioactive metabolites. It is specifically catered to pharmaceutical R&D laboratories, phytochemical researchers, and natural product chemists who require a reliable, highly soluble (in DMSO, methanol, and water) reagent to study anti-inflammatory mechanisms, validate analytical methods for traditional medicines like "Bai Ji", and explore novel glycoside-based therapeutic leads.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Dactylorhin A
CAS NO.	256459-34-4
Appearance	White to off-white powder
Molecular Formula	C40H56O22
Molecular Weight	888.86g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in DMSO, Methanol, Ethanol, Pyridine; slightly soluble in water
Endotoxin	< 10 EU/mg
Biological Activity	Succinate derivative ester isolated from Gymnadenia conopsea; exhibits moderate inhibitory effects on nitric oxide (NO) production in RAW 264.7 macrophage cells, indicating anti-inflammatory potential.
Storage Conditions	Store at -20°C, protected from light and moisture. Keep container tightly sealed.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Dactylorhin A exerts its primary biological effects by directly interfering with the inflammatory signaling cascade within macrophages, specifically targeting the suppression of inducible nitric oxide synthase (iNOS) activity to reduce the overproduction of nitric oxide (NO). Upon exposure to lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells, the compound modulates the intracellular environment to inhibit the enzymatic conversion of L-arginine to L-citrulline and NO, thereby downregulating the excessive generation of this reactive nitrogen species. This action helps prevent the subsequent chain reactions associated with nitrosative stress, such as the formation of peroxynitrite and the depletion of cellular glutathione, effectively shifting the cellular redox state away from a pro-inflammatory and cytotoxic condition without directly scavenging free radicals in a simple stoichiometric manner.

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2.PRODUCT INDICATIONS

Dactylorhin A is indicated strictly for non-clinical, in vitro research applications focused on inflammation biology, where it is utilized as a standard inhibitor of NO production to evaluate the anti-inflammatory potential of novel drug candidates and natural extracts. Researchers employ this compound to study the biochemical pathways of macrophage activation, the regulation of iNOS expression, and the screening of botanicals for anti-inflammatory or antioxidant properties in cell-based assays. Additionally, it serves as a primary pharmaceutical and phytochemical reference standard for analytical chemists developing chromatographic methods to quantify phenylethanol glycosides in Bletilla striataand Gymnadeniaspecies extracts, catering to professionals in traditional medicine quality control, natural product drug discovery, and preclinical validation of anti-inflammatory agents derived from orchidaceae family plants.

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3.CLINICAL EFFICACY OF PRODUCT

Dactylorhin A has demonstrated significant efficacy in preclinical cellular evaluations, showing a moderate yet distinct inhibitory effect on nitric oxide (NO) production in LPS-induced RAW 264.7 macrophage cells at non-cytotoxic concentrations. Experimental data confirms that the compound effectively reduces the accumulation of NO in the culture supernatant, performing as a consistent and reproducible standard for anti-inflammatory screening compared to baseline controls. These findings establish its robust utility as a biochemical probe for studying iNOS-mediated pathways and validate its role as a key bioactive marker in orchid extracts, providing researchers with a reliable tool to benchmark the anti-inflammatory potency of test substances and to further elucidate the structure-activity relationships of natural phenylethanol glycosides in immunological models.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

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Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: Dactylorhin A, Phenylethanol Glycoside, Succinate Derivative Ester, Anti-inflammatory, NO Production Inhibitor, iNOS Modulator, Natural Product, Phytochemical, Research Standard, Gymnadenia Conopsea, Bletilla Striata, Orchidaceae, Macrophage Assay, Traditional Medicine Standard

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