High Purity Licochalcone B CAS 58749238 China Suppliers and Factory
Licochalcone B (CAS NO.58749-23-8) is a high-purity natural chalcone renowned for its potent biological activities. Serving as a critical tool in preclinical oncology and immunology research, this compound is specifically engineered for scientists investigating the inhibition of NF-κB and STAT3 signaling pathways. Its exceptional antioxidant and anti-inflammatory properties make it an invaluable lead compound for the development of next-generation therapeutics targeting chronic inflammatory diseases and chemotherapy-resistant cancers.
Our Licochalcone B is produced under rigorous quality control standards, ensuring a purity of ≥98.0% via RP-HPLC. By modulating intracellular signaling and inducing mitochondrial-mediated apoptosis in malignant cells, it provides a reliable foundation for in vitro and in vivo studies. Whether used in molecular pharmacology or herbal medicine validation, this research-grade chemical offers the stability and precision required for high-impact scientific discovery.
Detailed Parameters
| Product Name | Licochalcone B | CAS NO. | 58749-23-8 |
|---|---|---|---|
| Appearance | Yellow to yellow-brown amorphous powder | Molecular Formula | C₁₆H₁₄O₅ |
| Molecular Weight | 286.28 g/mol | Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in DMSO, methanol, ethanol | Endotoxin | < 1 EU/mg (for solution) |
| Storage Condition | Store at -20°C, protected from light | MOQ | 1 mg |
Key Advantages
Ultra-High Purity
Guaranteed ≥98.0% purity via RP-HPLC, ensuring consistent and reproducible results in sensitive biochemical assays.
Multi-Pathway Inhibition
Effectively inhibits NF-κB and STAT3, critical regulators of inflammation and cell proliferation.
Potent Bioactivity
Demonstrated antioxidant, anticancer, and antibacterial activities suitable for diverse disease models.
Synergistic Effect
Enhances the cytotoxicity of conventional chemotherapeutics while potentially reducing systemic side effects.
BBB Permeability
Ability to penetrate the blood-brain barrier, offering potential for neuroinflammatory research.
Full Documentation
Every batch includes a comprehensive COA, HPLC reports, and MS chromatograms for total transparency.
Product Gallery
Management Platforms
GMP Production
Production partners utilize GMP-compliant systems for pharmaceutical-grade synthesis.
Quality Control
Standardized QC processes covering raw materials to final packaging.
Global Logistics
Rapid delivery via DHL, FedEx, UPS, and TNT with real-time tracking.
Batch Traceability
Rigorous stability data and traceability for every production lot.
Flexible Scaling
Support for diverse requirements ranging from milligram to ton-level supply.
Regulatory Compliance
Strict adherence to international trade and pharmaceutical quality standards.
Research Application Comparison
| Target Area | Standard Compound | Licochalcone B |
|---|---|---|
| Inflammation | General NSAIDs | Specific NF-κB/STAT3 Inhibition |
| Cancer Research | Cytotoxic Agents | Induces Apoptosis via Bax/Bcl-2 |
| Oxidative Stress | Basic Antioxidants | Potent ROS Scavenging |
| Neuro-inflammation | Limited Permeability | BBB Penetrating Capacity |
| Synergy | Single Action | Enhanced Chemotherapy Efficacy |
Frequently Asked Questions
It is primarily used in preclinical research for oncology, immunology, and inflammatory diseases, specifically as a lead compound for drug development targeting cancer, arthritis, and neurodegenerative disorders.
To ensure maximum stability and purity, the product should be stored at -20°C and kept protected from light and moisture.
Every batch is accompanied by a Certificate of Analysis (COA), RP-HPLC purity report, and mass spectrometry (MS) chromatograms.
No, Licochalcone B is currently a research chemical intended for in vitro and in vivo preclinical studies and is not yet approved for clinical human application.
It induces mitochondrial-mediated apoptosis by upregulating pro-apoptotic proteins (Bax) and downregulating anti-apoptotic proteins (Bcl-2), while disrupting microtubule assembly.
The minimum order quantity is 1 mg, making it accessible for small-scale pilot studies as well as large-scale industrial manufacturing.
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