Cecropin B CAS 80451054 Antimicrobial Peptide China Suppliers Factory
Cecropin B (CAS NO.80451-05-4) is a high-purity antimicrobial peptide (AMP) renowned for its potent bactericidal activity and unique membrane-disruption mechanism. Specifically designed for laboratory research and preclinical studies, this cationic peptide targets the fundamental integrity of microbial envelopes, providing a robust tool for scientists investigating multidrug-resistant pathogens and membrane biology.
Engineered to bypass classical microbial resistance, Cecropin B exerts its effects through electrostatic attraction to negatively charged phospholipids, forming toroidal pores that lead to osmotic lysis. Its broad-spectrum efficacy against Gram-negative bacteria, combined with observed anticancer and immunomodulatory properties, makes it an indispensable reference compound in the development of next-generation synergistic antimicrobial therapies.
Detailed Parameters
| Product Name | Cecropin B | CAS NO. | 80451-05-4 |
|---|---|---|---|
| Molecular Formula | C176H302N52O41S1 | Molecular Weight | 3734.73 g/mol |
| Purity (RP-HPLC) | ≥98.0% | Appearance | White to off-white lyophilized powder |
| Solubility | Water, dilute acetic acid | Endotoxin | ≤0.5 EU/mg |
| Storage Conditions | -20°C, dry and dark | MOQ | 1g |
Key Advantages
Resistance Barrier
Targets the physical integrity of cell membranes, significantly reducing the likelihood of microbial resistance development.
Rapid Killing Kinetics
Demonstrates fast bactericidal action at micromolar concentrations against diverse pathogens including E. coli.
High Purity Grade
RP-HPLC purity ≥98.0% ensures reliable and reproducible results for sensitive preclinical research.
Broad Spectrum
Effective against ESKAPE organisms and multi-drug resistant clinical isolates in various assays.
Multifunctional Use
Applicable in antimicrobial discovery, cancer cell proliferation studies, and immunomodulatory research.
Full Traceability
Every batch is accompanied by a COA, HPLC report, and MS chromatograms for total transparency.
Product Gallery
Management Platforms
GMP Production
All partners utilize GMP-compliant systems for synthesis and purification.
Quality Control
Standardized QC processes covering raw materials to final packaging.
Batch Stability
Rigorous stability data monitoring to ensure consistent performance across batches.
Global Logistics
Secure air freight via DHL/FedEx with specialized temperature-controlled packaging.
Flexible Scale
Capability to supply from gram-level research quantities to ton-level industrial production.
Regulatory Compliance
Adherence to international trade standards and pharmaceutical quality certifications.
Investment Return Comparison
| Metric | Standard Peptides | GlobalTech Cecropin B |
|---|---|---|
| Purity Level | ≥95% | ≥98.0% (HPLC) |
| Resistance Risk | Higher (Metabolic) | Very Low (Physical Lysis) |
| Killing Speed | Variable | Rapid (Micromolar) |
| Documentation | Basic COA | COA + HPLC + MS Reports |
| Application Range | Single Target | Multi-pathogen/Anticancer |
Frequently Asked Questions
Cecropin B uses a membrane-disruption mechanism. It is electrostatically attracted to negatively charged microbial membranes, where it forms an alpha-helix structure and creates pores, leading to osmotic lysis of the target cell.
No, Cecropin B is strictly designated for laboratory research, preclinical studies, and quality control applications within academic and pharmaceutical settings.
It should be stored at -20°C in a dry, dark, and well-sealed container. It is critical to avoid repeated freeze-thaw cycles to preserve the peptide's biological activity.
It shows potent activity against a broad spectrum of pathogens, particularly Gram-negative bacteria such as Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii.
Our production partners employ GMP-compliant systems. Each shipment includes a Certificate of Analysis (COA), HPLC purity report, and mass spectrometry (MS) chromatograms.
Yes, preclinical studies have demonstrated that Cecropin B can act as a synergistic agent when combined with conventional antibiotics, such as beta-lactams, to reduce mortality in sepsis models.
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