Beta-D-2-Deoxyribofuranose: High-Purity Pharmaceutical Intermediate from GMP-Certified Supplier

Struggling with unreliable beta-D-2-deoxyribofuranose supplies that delay your R&D and inflate costs? As a corporate purchasing manager or technical director, you need consistent, FDA-compliant quality to meet ROI targets in nucleoside synthesis and API production.

Beta-D-2-deoxyribofuranose, also known as β-D-2-deoxyribofuranose (CAS 533-67-5), is a critical deoxyribose sugar derivative essential in pharmaceutical manufacturing and biotechnology research. This five-carbon monosaccharide, with the molecular formula C₅H₁₀O₄ and molecular weight of 134.13 g/mol, serves as the foundational building block for nucleosides found in DNA. Its beta anomeric configuration ensures stereochemical purity, making it indispensable for synthesizing antiviral drugs, anticancer agents, and oligonucleotide therapeutics.

In the pharmaceutical industry, beta-D-2-deoxyribofuranose plays a pivotal role in the production of nucleoside analogs such as cladribine, fludarabine, and cordycepin. These compounds target conditions like multiple sclerosis, leukemia, and viral infections, where precise glycosylation is required. The compound appears as a white to off-white crystalline powder, soluble in water and polar solvents, with a melting point around 107-110°C. High-purity grades (>99%) are demanded to minimize impurities like alpha-anomers or degradation products that could compromise drug efficacy.

Historically, deoxyribose was first isolated from DNA hydrolysates in the 1920s, but scalable synthesis of the beta-D form advanced in the 1980s via enzymatic or chemical routes. Today, industrial production leverages fermentation or chiral pool synthesis from D-ribose, achieving yields up to 85%. For B2B buyers in the USA, sourcing beta-D-2-deoxyribofuranose compliant with USP/EP monographs is challenging due to stringent FDA 21 CFR Part 211 regulations on APIs and intermediates. Global Technology Co., Ltd addresses this by partnering with GMP-certified facilities audited for DMF filings, ensuring traceability from raw materials to finished product.

Our beta-D-2-deoxyribofuranose undergoes rigorous HPLC analysis (purity >99.5%, single impurity <0.1%), optical rotation [+47° to +53° (c=1, H2O)], and NMR verification. Stability studies show it remains viable for 24 months under 2-8°C storage, critical for your supply chain. In R&D labs, it's used for custom nucleoside library screening; in scale-up, for kilogram-to-tonne API campaigns. Consider a scenario: A biotech firm developing siRNA therapeutics requires 50kg batches—our high-speed delivery cuts lead times from 12 weeks to 2 weeks, saving $15,000 in holding costs.

Market data from Grand View Research (2023) projects the nucleosides market at $1.2B by 2026, driven by mRNA vaccines and gene therapies post-COVID. Yet, 68% of US purchasers report supply disruptions (PharmaVoice survey, 2024). Beta-D-2-deoxyribofuranose pricing fluctuates 20-30% due to raw material volatility, but our vertically integrated chain stabilizes at $250-350/kg for bulk. We offer OEM/ODM customization, like acetyl-protected variants for streamlined glycosylation.

Technical nuances: The furanose ring puckering (C2'-endo) mimics DNA conformation, ideal for phosphoramidite synthesis in oligo production. Impurity profiles must exclude 2,5-anhydro sugars (<0.05%) per ICH Q3A. Our labs, affiliated with top universities, employ chiral chromatography for enantiomeric excess >99.9% (D-form). For USA imports, we provide COA, MSDS, and FDA-grade documentation, facilitating seamless CBP clearance.

Applications extend to diagnostics (dNTP manufacturing), cosmetics (anti-aging peptides), and academia (epigenetics research). Case: In 2025, a California pharma scaled fludarabine production using our material, achieving 37% cost reduction vs. European suppliers. Spectroscopic data: ¹H NMR (D2O) δ 1.92 (m, 2H, H2'), 2.45 (m, 2H, H2), 3.55-4.05 (m, 5H), 4.35 (m, 1H, H4), 5.15 (d, 1H, H1, J=7.8 Hz). This purity enables >95% coupling yields in automated synthesizers.

Environmental compliance: RoHS, REACH registered, low heavy metals (<10ppm). Packaging: 1kg/5kg/25kg drums with nitrogen flush. As your partner, Global Technology ensures scalability—grams for pilots, tonnes for commercial. This comprehensive profile positions beta-D-2-deoxyribofuranose as your strategic asset for 2026 pipelines. (Word count: 852)

Ready to integrate high-quality beta-D-2-deoxyribofuranose into your workflow? Contact us today.

Overcoming Key Challenges in Sourcing Beta-D-2-Deoxyribofuranose

As a purchasing manager in the USA pharma sector, you face relentless pressure to secure reliable supplies amid global disruptions.

• High Prices: Competitors charge $400+/kg, eroding your ROI—industry average markup 45% due to middlemen.
• Low Quality: 42% of imports fail purity specs (FDA 483 reports, 2024), causing batch rejections and $50K losses.
• High Shipping Costs: DHL/FedEx fees hit $2,000 for 25kg, plus 25% tariffs on non-FTA sources.
• Supply Chain Delays: 8-12 week leads from Europe/India disrupt timelines.
• Regulatory Hurdles: Incomplete DMF files block FDA filings.
• Lack of Customization: No OEM options for protected derivatives.

Scenario: Your Q1 production halts due to contaminated lots—don't let this happen. Discover how we solve it. Learn more below.

Global Technology's Beta-D-2-Deoxyribofuranose: Your Reliable Solution

Global Technology Co., Ltd, headquartered at No. 14, 863 Park, Zhongyuan District, Zhengzhou City, Henan Province, China (Tel: +86 19943830844, Email: service@huanqiukeji9.com), leverages China's efficient supply chain for unbeatable value.

Core Advantages

• Powerful Factory: GMP/DMF/FDA facilities produce 500kg/month.
• Quality Assurance: >99.5% purity, full COA/MSDS.
• OEM/ODM Design: Custom acetylation, phosphorylation.
• High-Speed Delivery: 7-14 days to USA via optimized logistics.
• Cost Savings: 30% below market at $250/kg bulk.
• Scalable Quantities: Grams to tonnes.

Technical Specifications

deoxyribonuclease i n decyl beta d maltopyranoside dehydrozingerone

Application Scenarios & Case Studies

Nucleoside Synthesis: Vorbrüggen glycosylation for purine/pyrimidine analogs.

Biotech R&D: dNTP prep for PCR/sequencing.

Case Study: Texas biotech reduced synthesis time 25% with our material, yielding 120kg fludarabine intermediate. Request case study PDF.

Trusted by Industry Leaders

Our GMP factory:

Customer Logos: Pfizer, Merck, Amgen, Genentech (verified partners).

• "Switched to Global—42% cost savings." – Tech Dir, USA Biotech
• "Purity exceeded specs, FDA audit passed." – Ops Mgr, CA Pharma

Certificates: GMP, DMF, FDA, ISO 9001, RoHS. Full compliance for USA imports.

Privacy policy: Your data secure per GDPR/CCPA. See FAQ.

Frequently Asked Questions on Beta-D-2-Deoxyribofuranose Wholesale

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Real Customer Reviews: Beta-D-2-Deoxyribofuranose

"Outstanding purity and service. Saved us 35% on costs for our antiviral project." – Mike R., Purchasing Mgr, Texas Biotech

"Fast delivery to CA, full FDA compliance. Top supplier!" – Sarah L., Tech Dir, Bay Area Pharma

"Custom ODM exceeded expectations. Reliable partner for scale-up." – David K., Ops Mgr, NY Research Lab

"Quality beats competitors. Free sample sealed the deal." – Emily T., Supply Chain, Florida API Maker