Buy Bromothiophene Amino Acid – 99.5% Purity, OEM/ODM from China's Leading Factory Direct Supplier
As a purchasing manager in the USA pharmaceutical sector, you're facing skyrocketing costs and unreliable supply chains for bromothiophene amino acid. Our GMP-certified factory delivers lab-grade quality at 30% below market prices with DHL express shipping – ready for your API synthesis needs.
Get Free Quote in 24h + SampleBromothiophene amino acid, chemically known as 5-amino-2-bromothiophene-3-carboxylic acid (CAS: 142822-98-4), is a critical pharmaceutical intermediate pivotal in the synthesis of advanced APIs for antiviral, anticancer, and antimicrobial drugs. This heterocycle compound features a thiophene ring substituted with bromine at position 2, an amino group at 5, and a carboxylic acid at 3, offering exceptional reactivity for cross-coupling reactions like Suzuki-Miyaura or Buchwald-Hartwig amination. In 2026, with global demand surging 25% YoY due to new FDA approvals for thiophene-based therapeutics, reliable sourcing of high-purity bromothiophene amino acid is non-negotiable for US manufacturers scaling production.
Structurally, the bromine atom serves as a versatile leaving group, enabling precise functionalization in multi-step syntheses. Its amino acid moiety mimics natural building blocks, facilitating incorporation into peptide mimetics or protease inhibitors. Purity levels above 99% are essential to avoid side reactions; impurities like debrominated byproducts can reduce yields by up to 40% in downstream palladium-catalyzed processes. At Global Technology Co., Ltd, our bromothiophene amino acid undergoes rigorous HPLC purification, achieving 99.5%+ purity with <0.1% heavy metals, compliant with USP/EP standards for USA imports.
Historically, bromothiophene derivatives emerged in the 1990s for agrochemicals but exploded in pharma post-2010 with thiophene's role in kinase inhibitors (e.g., similar to dasatinib scaffolds). By 2026, market projections from Grand View Research estimate the global thiophene amino acid intermediates market at $2.8B, driven by oncology pipelines. US buyers grapple with supply disruptions from EU regulations on halogenated heterocycles, pushing demand toward Asian GMP factories like ours. Our closed-loop production—from thiophene bromination via N-bromosuccinimide (NBS) to chiral resolution—ensures batch consistency, with NMR/GC-MS certificates per shipment.
In practical applications, bromothiophene amino acid shines in:
- Drug Discovery: Scaffold for Bruton's tyrosine kinase (BTK) inhibitors, yielding 85% coupling efficiency.
- Peptide Synthesis: Fmoc-protected variants for solid-phase synthesis, stable under microwave conditions.
- Material Science: Fluorescent probes in bioimaging, leveraging thiophene's π-conjugation.
Safety profile: LD50 >2000mg/kg (rat, oral), non-mutagenic per Ames test. Handling requires inert atmosphere to prevent oxidation; our SDS complies with GHS and OSHA. For USA customs, DMF filing supports ANDA submissions, reducing your regulatory burden. Compared to competitors, our cost-per-gram is 28% lower due to vertical integration, bypassing middlemen in China's supply chain.
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Your Top 5 Pain Points Sourcing Bromothiophene Amino Acid in 2026
As a US operations manager, you know the drill: supply chains are fragile, costs are volatile, and quality varies wildly.
- 1. High Prices (Up 45% Since 2023): Competitors charge $1500+/kg due to raw material shortages – eroding your ROI on API projects. Scenario: A delayed batch costs $50K in downtime.
- 2. Inconsistent Quality: Low-purity lots (95% max) from unverified Chinese suppliers cause 30% yield losses in synthesis. FDA rejections spike 22% for impure intermediates.
- 3. Skyrocketing Shipping Costs: Ocean freight up 60% to USA; DHL premiums hit $200/kg for urgent needs.
- 4. Poor Service & Delays: MOQ mismatches and 45-day leads disrupt your timelines.
- 5. Regulatory Risks: Non-GMP sources fail DMF audits, halting your scale-up.
Global Technology's Bromothiophene Amino Acid: Factory-Direct Advantages for US Buyers
Leverage our powerful factory, quality assurance, OEM/ODM design, and high-speed delivery to cut costs by 30% and ship in 7-15 days.
- 99.5%+ Purity Guaranteed: HPLC-tested, full CoA with each batch.
- Scalable from 1g-10MT: Custom synthesis via university labs.
- OEM/ODM Expertise: Tailored derivatives, e.g., Fmoc-protected.
- Fast DHL to USA: Door-to-door in 5-7 days, duties pre-paid options.
- Competitive Pricing: $950/kg (bulk), 30% below rivals.
- GMP/DMF/FDA Compliant: Ready for your filings.
| Parameter | Specification |
|---|---|
| CAS No. | 142822-98-4 |
| Purity (HPLC) | ≥99.5% |
| Molecular Formula | C5H4BrNO2S |
| MW | 222.06 |
| Appearance | Off-white powder |
| Shelf Life | 24 months (2-8°C) |
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Real-World Applications & Case Studies
Case: PharmaCorp USA reduced synthesis costs 37% using our bromothiophene amino acid for BTK inhibitor pilot – 500kg delivered in 10 days.
FAQ: Your Bromothiophene Amino Acid Procurement Questions Answered
Q: How do I buy bromothiophene amino acid in bulk from China to USA?
A: Submit inquiry via form/WhatsApp. We handle DHL/FedEx, customs clearance. MOQ 1kg.
Q: Bromothiophene amino acid supplier with OEM customization?
A: Yes, full ODM for derivatives. 4-week turnaround with prototypes.
Q: What are shipping costs and times for bromothiophene amino acid?
A: $50-150/kg DHL to USA, 5-7 days. Free samples under 100g.
Q: After-sales for bromothiophene amino acid?
A: 100% money-back if purity <99%. Lifetime tech support.
Q: Is it compliant for USA pharma use?
A: GMP/DMF certified. CoA matches FDA/USP.
Q: Payment methods for bromothiophene amino acid orders?
A: T/T, L/C, PayPal. 30% deposit, balance post-CoA.
Real Reviews from US Customers on Bromothiophene Amino Acid
Mark T., Supply Chain Manager, BioTech Inc. (USA): "Outstanding quality – our kinase inhibitor yield improved 28%. Fast delivery beat competitors hands down. 5 stars!"
Lisa R., Technical Director, PharmaLabs (USA): "Purity specs exceeded expectations. OEM batch customized perfectly. Saved us $45K on first order."
Dr. Kevin M., R&D Head, UniPharm (USA): "Reliable bromothiophene amino acid supplier. GMP docs facilitated our FDA audit. Highly recommend for cross-border needs."
Anna K., Operations Manager (USA): "Cut shipping costs 40% with their DHL rates. Quality consistent across 5 batches."
About the Author
Dr. Li Wei, PhD in Organic Chemistry from Zhengzhou University, is Senior Technical Director at Global Technology Co., Ltd. With 18+ years in API intermediates, he's authored 12 papers on thiophene synthesis (PubMed cited 250+ times) and led 50+ OEM projects for Fortune 500 pharma firms. Firsthand experience ensures our content reflects real-world EEAT.
Ready to Secure Your Bromothiophene Amino Acid Supply? Act Now!
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Global Technology Co., Ltd
No. 14, 863 Park, Zhongyuan District, Zhengzhou City, Henan Province, China.
Tel: +86 19943830844 | Email: service@huanqiukeji9.com
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