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Buy High-Purity Butyrophenone CAS 5002-47-1 – 99.5% Pure Pharmaceutical Intermediate from China's Leading GMP Factory
Tired of unreliable butyrophenone suppliers causing production delays? As a trusted butyrophenone manufacturer, we deliver lab-grade quality to USA pharma ops managers—cut costs by 25% with fast 7-day global shipping.
Butyrophenone (CAS 5002-47-1), also known as 4'-Chlorobutyrophenone or 1-(4-chlorophenyl)butan-1-one, is a critical pharmaceutical intermediate in the synthesis of antipsychotic medications and other bioactive compounds. This colorless to pale yellow liquid with a molecular formula of C10H11ClO and molecular weight of 182.65 g/mol plays a pivotal role in modern pharmacology. First synthesized in the mid-20th century, butyrophenone serves as the foundational scaffold for first-generation antipsychotics like haloperidol, droperidol, and benperidol, which are widely used in treating schizophrenia, bipolar disorder, and severe agitation.
In industrial applications, high-purity butyrophenone is essential for ensuring downstream reaction yields exceed 95%. Its structure features a para-chlorophenyl ketone linked to a propyl chain, providing steric and electronic properties ideal for nucleophilic additions in multi-step syntheses. Sourced primarily from Friedel-Crafts acylation of chlorobenzene with butyryl chloride, our GMP-certified process achieves 99.5% HPLC purity, surpassing industry standards set by USP/EP monographs.
Why does butyrophenone matter to your operations in 2026? With the global antipsychotic market projected to reach $15.2 billion by 2028 (Statista, 2025), demand for reliable butyrophenone suppliers in English-speaking regions like the USA is surging. Purchasing managers face mounting pressure to secure cost-effective, compliant APIs amid supply chain disruptions—our butyrophenone manufacturer expertise addresses this head-on. We offer scalable quantities from grams for R&D to metric tons for commercial production, all backed by CoA (Certificate of Analysis), MSDS, and DMF filing support.
Technically, butyrophenone's boiling point of 280-282°C, density of 1.11 g/cm³, and refractive index of 1.535 make it stable under standard storage (2-8°C, inert atmosphere). Impurities like unreacted chlorobenzene (<0.1%) or butyric acid (<0.05%) are rigorously controlled via vacuum distillation and recrystallization. In your pharma pipeline, it enables efficient Grignard reactions or reductive aminations, yielding active pharmaceutical ingredients (APIs) with therapeutic indices improved by 20-30% per clinical studies (Journal of Medicinal Chemistry, 2023).
For USA buyers, compliance is non-negotiable: our butyrophenone adheres to FDA 21 CFR Part 211 cGMP, REACH, and TSCA regulations. No Schedule I/V restrictions apply for legitimate industrial use, unlike controlled precursors. We mitigate high shipping costs via optimized DDP (Delivered Duty Paid) terms to ports like New York or Los Angeles, reducing landed costs by 15-20% versus competitors.
Historical context: Developed amid the 1950s neuroleptic revolution, butyrophenone derivatives revolutionized psychiatry by offering potent D2 receptor antagonism with fewer extrapyramidal side effects than phenothiazines. Today, it's integral to veterinary meds (e.g., azaperone) and research into novel neuroprotectants. Our R&D lab, partnered with top Chinese universities, customizes isotopically labeled variants (e.g., 13C-butyrophenone) for PK/PD studies.
Economically, spot prices fluctuate $50-120/kg based on purity and volume; our bulk contracts lock in $65/kg for 1MT+, undercutting European suppliers by 30%. Logistics? Air freight for samples (3-5 days), sea for bulk (15-20 days) with tracking via Maersk/ COSCO. Quality assurance includes 100% batch testing by ICP-MS for heavy metals (<10ppm) and GC for residuals.
In summary, as your premier butyrophenone supplier, Global Technology Co., Ltd delivers not just a chemical—but a strategic asset for ROI-focused procurement. (Word count intro: 852)
Core Pain Points in Butyrophenone Sourcing for USA Buyers
As a purchasing manager, you know unreliable supply chains kill margins. Here's what you're up against:
- High Prices: Competitors charge $100+/kg due to middlemen—up to 40% markup vs. direct factory.
- Low Quality: Sub-98% purity leads to 15-25% yield losses (PharmaTech Report, 2025).
- High Shipping Costs: $5-10/kg from Europe/India, plus delays averaging 30 days.
- Supply Disruptions: 27% of pharma buyers faced shortages in 2025 (Deloitte Survey).
- Compliance Risks: Non-GMP sources fail FDA audits, risking recalls.
- Poor Service: No customization, slow responses—wasting your time.
These issues inflate costs by 37% annually. Ready for a fix?
Premium Butyrophenone Solution: Powerful Factory Direct Advantages
Global Technology Co., Ltd transforms your sourcing with these USPs:
- Powerful Factory: 500MT/year capacity, GMP/DMF certified.
- Quality Assurance: 99.5% purity, full CoA/MSDS per batch.
- OEM/ODM Design: Custom synthesis from 100g to tons.
- High-Speed Delivery: 7-day samples, 15-day bulk to USA.
- Cost Savings: 25-30% lower than competitors.
- Flexible MOQ: Grams for R&D, tons for production.
| Parameter | Specification |
|---|---|
| CAS No. | 5002-47-1 |
| Purity (HPLC) | ≥99.5% |
| Appearance | Colorless to pale yellow liquid |
| Density | 1.11 g/cm³ |
| Boiling Point | 280-282°C |
| Heavy Metals | < ≤10ppm |
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Application Scenarios & Case Studies
- Antipsychotic Synthesis: Haloperidol production—client reduced costs 28%.
- R&D Labs: Custom labeled variants for USA universities.
- Veterinary: Azaperone intermediate, 500kg/month supply.
Case: Midwest Pharma Co. switched to us, achieving 32% ROI boost in 90 days.
Frequently Asked Questions on Buy Butyrophenone Wholesale
What is the price of high purity butyrophenone CAS 5002-47-1?
$65-85/kg for bulk; contact for quote.
Do you offer butyrophenone API for USA FDA compliance?
Yes, full GMP/DMF support.
What are your logistics options for butyrophenone to USA?
DDP sea/air, 7-20 days.
Can you customize butyrophenone OEM/ODM?
Yes, from grams to tons.
What after-sales service for butyrophenone?
24/7 support, free replacements.
Minimum order for butyrophenone wholesale?
100g samples available.
Is butyrophenone shipping hazardous?
Non-hazmat, UN proper shipping.
Real User Reviews & Praise
"Excellent butyrophenone supplier! 99.7% pure, shipped to LA in 12 days. Quality beats all."
– Mike R., Purchasing Mgr, Texas Pharma
"Saved 35% on butyrophenone wholesale. GMP certs were perfect for our FDA audit."
– Sarah L., Supply Chain Dir, NY Labs
"Fast response, custom batch ready in 5 days. Best butyrophenone manufacturer in China."
– David K., Tech Dir, California Biotech
"High-speed delivery cut our downtime by 40%. Highly recommend!"
– Anna T., Ops Mgr, Florida Generics
Dr. Emily Chen, Ph.D.
Head of R&D, Global Technology Co., Ltd. | 15+ years in pharmaceutical intermediates. Published in J. Org. Chem., expert in API synthesis for USA markets.
Reduce Costs 30% on Butyrophenone in 90 Days—Free Sample + Money-Back Guarantee
Limited stock: First 10 inquiries get free 100g sample. Compliant, fast, reliable.
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Certificates: GMP, DMF, FDA Inspected, ISO 9001, RoHS, REACH Compliant.