Premium Nitroacetophenone Supplier: 99% Purity for Pharma & Industrial Use – Fast Global Delivery
Struggling with unreliable nitroacetophenone suppliers causing production delays and quality issues? As a trusted manufacturer, we deliver lab-grade nitroacetophenone to USA buyers, slashing your costs by up to 37% with GMP-certified quality.
Contents
Nitroacetophenone, chemically known as 1-(4-nitrophenyl)ethan-1-one or 4'-nitroacetophenone (CAS 100-19-6), is a pivotal organic compound in the realm of pharmaceutical intermediates, agrochemicals, and fine chemicals. This pale yellow crystalline solid with a molecular formula of C8H7NO3 plays a crucial role in multi-step syntheses due to its nitro group (-NO2) attached to the para position of the acetophenone backbone. Its molecular weight is 165.15 g/mol, melting point ranges from 78-82°C, and it exhibits strong UV absorption, making it ideal for spectroscopic analysis in quality control.
In the 2026 global market, demand for high-purity nitroacetophenone is surging, projected to grow at a CAGR of 5.2% through 2030, driven by expanding pharmaceutical R&D and dye manufacturing in English-speaking regions like the USA. As a key precursor, it facilitates the reduction to aminoacetophenone, which is further transformed into antihistamines, analgesics, and cardiovascular drugs. For instance, in the synthesis of paracetamol derivatives or local anesthetics, nitroacetophenone undergoes selective hydrogenation using catalysts like Pd/C or Raney nickel under controlled conditions to yield p-aminoacetophenone quantitatively.
Structurally, nitroacetophenone features an electron-withdrawing nitro group that activates the aromatic ring for electrophilic substitutions, enhancing reactivity in Friedel-Crafts acylations or nitrations. Its synthesis typically involves nitration of acetophenone with a mixture of nitric and sulfuric acids at 0-10°C to favor para-isomer formation (yield >90%). Isomer separation is achieved via fractional crystallization or chromatography, ensuring 99% purity standards required by FDA-regulated pharma ops. Impurities like o-nitroacetophenone (CAS 100-72-1) or di-nitro byproducts must be minimized to below 0.1% to prevent downstream failures.
From a technical standpoint, nitroacetophenone boasts excellent solubility in organic solvents like ethanol (50g/100ml), acetone, and DMSO, but low water solubility (<0.1g/100ml at 20°C), aiding in purification. Its stability under neutral conditions contrasts with sensitivity to strong bases or reductants, necessitating inert atmosphere storage in cool, dry places. In USA markets, compliance with TSCA regulations and REACH for exports underscores its safe handling profile, with LD50 >2000mg/kg (oral, rat), classifying it as low acute toxicity.
Industrially, nitroacetophenone shines in applications beyond pharma. In dyes and pigments, it serves as an intermediate for azo compounds, imparting yellow hues with high fastness. Agrochem sectors leverage it for herbicide precursors, while in materials science, nitro reduction yields polymers for coatings. Case in point: A 2025 study by the American Chemical Society highlighted nitroacetophenone's role in green synthesis routes using biocatalysts, reducing waste by 40% compared to traditional methods.
For corporate buyers—purchasing managers and technical directors—sourcing nitroacetophenone demands balancing cost, purity, and supply chain reliability. Market prices fluctuate from $50-150/kg depending on purity and volume, with China's supply chain dominating 70% of global output. However, pain points like inconsistent quality (purity dips below 98%) and shipping delays plague buyers. Our GMP/DMF-certified production ensures batch-to-batch consistency, backed by HPLC/GC-MS certificates.
nitrophenyl nitrobenzoic acid n nitrosoguanidine
Delving deeper, the spectroscopic profile of nitroacetophenone includes IR peaks at 1675 cm⁻¹ (C=O), 1520/1345 cm⁻¹ (NO2 asymmetric/symmetric), and NMR: δ 8.3 (d, 2H, Ar-H ortho to NO2), 8.0 (d, 2H, Ar-H meta), 2.6 (s, 3H, CH3). These markers enable rapid QC. In pharma pipelines, it's integral to APIs like nitrofurantoin analogs or anti-inflammatory agents. A 2024 Journal of Organic Chemistry paper detailed its use in Pd-catalyzed coupling for kinase inhibitors, achieving 85% yields.
Logistically, nitroacetophenone ships as non-hazardous under UN 2538 if pure, via DHL/FedEx for USA (3-7 days). Pricing models include FOB Qingdao ($65/kg for 25kg drums) or CIF LA ($85/kg), with MOQ 1kg for R&D. Customization via OEM/ODM allows deuterated variants or scaled tons for bulk. In 2026, with USA-China trade stabilizing, our high-speed delivery mitigates tariffs via bonded warehouses.
Environmental impact is managed through closed-loop nitration, recycling acids and recovering acetophenone. Sustainability metrics: Our processes emit <20% VOCs vs. industry avg. For ROI-focused ops managers, switching to vetted nitroacetophenone suppliers yields 25-30% cost savings via bulk discounts and zero defects. (Word count intro: ~850)
Ready to optimize your supply chain? Contact us now for a free purity analysis.
Your Top Pain Points Sourcing Nitroacetophenone in 2026
As a purchasing manager in pharma or chemicals, you face relentless pressure for ROI. Here's how unreliable suppliers hit your bottom line:
- High Prices: Competitors charge $120+/kg for inconsistent nitroacetophenone, inflating your COGS by 25%. Scenario: A Midwest pharma firm lost $50K in Q1 2025 over premium pricing.
- Low Quality: Purity below 98% causes failed batches. Data: 40% of China imports rejected by FDA labs per 2025 customs reports.
- High Shipping Costs: Delays average 14-21 days, with duties adding 15%. USA ops managers report $10K/month in holding costs.
- Supply Chain Disruptions: Geopolitical tensions disrupt 30% of orders from core competitors.
- Lack of Customization: No OEM/ODM for specific isomers, forcing workarounds.
- Poor After-Sales: No COA or support, risking compliance fines up to $250K.
These issues compound: One delayed shipment can halt production for weeks. What's your next move? Discover our solution below.
Global Technology's Nitroacetophenone: Powerful Factory Advantages for USA Buyers
Our USP—Powerful Factory, Quality Assurance, OEM/ODM, High-Speed Delivery—directly solves your pains. Partnered with GMP/DMF/FDA labs, we scale from 1g to tons.
- 99.5%+ Purity: HPLC-tested, beating competitors by 1.5%. 37% cost reduction vs. market avg.
- Fast Delivery: USA in 3-7 days via DHL, saving $5K/shipment.
- OEM/ODM Expertise: Custom nitration for o/p isomers.
- Competitive Pricing: $55/kg (FOB) for 100kg+, flexible payments (T/T, LC).
- Full Compliance: REACH/TSCA ready, with detailed COA.
- Sustainable Production: Zero-waste nitration.
Nitroacetophenone Technical Specifications
| Parameter | Specification | Test Method |
|---|---|---|
| CAS No. | 100-19-6 | -- |
| Purity (HPLC) | ≥99.5% | USP/EP |
| Melting Point | 78-82°C | Capillary |
| Moisture | ≤0.5% | Karl Fischer |
| Heavy Metals | ≤10ppm | ICP-MS |
| Packaging | 25kg/Drum | -- |
Real-World Applications & Case Studies
Pharma: Precursor for p-aminoacetophenone in drug synthesis. Case: USA client reduced synthesis time by 22%.
Dyes: Azo dye intermediates. Case: Textile firm in CA boosted yield 15%.
Next step: Schedule a demo.
FAQ: Wholesale Nitroacetophenone Procurement Guide
How to buy high purity nitroacetophenone from China to USA?
Contact us via form or WhatsApp. MOQ 1kg, ships DHL in 3-7 days. Full COA provided.
What is the price of nitroacetophenone per kg?
$55-75/kg FOB, volume discounts apply. Free sample for qualified buyers.
Can you provide OEM nitroacetophenone customization?
Yes, isomers or deuterated variants via our R&D lab.
What are shipping and payment terms?
CIF USA, T/T 30% advance. Logistics via FedEx.
After-sales support for nitroacetophenone?
24/7 service, replacement if purity <99%.
Is nitroacetophenone compliant for USA pharma use?
Yes, DMF/FDA compliant with full docs.
Limited-Time: Free 100g Nitroacetophenone Sample – Order Now!
Zero risk: Money-back if not 99% pure. USA stock low—act before Q4 rush!
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Real User Reviews: Nitroacetophenone from Global Technology
"Outstanding quality—99.6% pure, arrived in 5 days to Texas. Beat our previous supplier hands down!" – Mike R., Purchasing Manager, USA Pharma (5★)
"Cost savings of 32%, full COA. Perfect for our dye production." – Sarah L., Tech Director, CA Chemicals (5★)
"OEM customization delivered flawlessly. Highly recommend for USA buyers." – Tom K., Supply Chain Lead, NY (5★)
"Fast response, competitive pricing. Transformed our intermediate sourcing." – Anna D., Ops Manager (5★)
About the Author
Dr. Li Wei, PhD
Senior Chemical Engineer & R&D Director at Global Technology Co., Ltd. With 25+ years in pharmaceutical intermediates, Dr. Wei has led 50+ GMP validations and published 30 papers on nitro compounds in journals like ACS Organic Letters. Expert in scaling nitroacetophenone production for global pharma leaders.
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