CAS 1566590-77-9 ADC Linker – High‑Purity, Fast‑Delivery Solution for Antibody‑Drug Conjugates
Accelerate your ADC program with a reliable, GMP‑grade linker that meets FDA, CE and ISO standards.
Get Free Quote in 24 hContents
Why Your ADC Projects Stall – Core Pain Points
1. High Cost of Low‑Yield Linkers – Most suppliers charge a premium for small‑batch, non‑GMP grades. Your R&D budget can balloon by 30‑45% before the first conjugation even begins.
2. Inconsistent Purity & Batch‑to‑Batch Variation – Impurities such as residual acids or di‑alkylamines cause unexpected linker‑drug release, jeopardizing safety data and delaying IND filing.
3. Slow Delivery & Expensive Freight – Overseas shipping from China often exceeds 30 days with hidden customs fees, extending your development timeline and inflating logistics cost by up to 25%.
4. Limited Customization Options – You need a linker with a specific spacer length or functional group (e.g., maleimide, azide) for site‑specific conjugation, yet many catalog items are “one‑size‑fits‑all.”
5. Regulatory Uncertainty – Without CE, FDA, ISO or GMP documentation, your procurement team spends extra weeks compiling compliance dossiers for the Quality Assurance department.
6. Poor Technical Support – When synthesis issues arise, generic customer service can’t provide the detailed reaction‑mechanism guidance required by a senior chemist.
Discover how Global Technology eliminates each of these risks →
Our ADC Linker Solution – Advantages & Specs
Core Advantages (Long‑Tail Keywords Integrated)
- OEM/ODM Design Flexibility – Tailor spacer length, cleavable vs. non‑cleavable, and orthogonal functional groups to match custom ADC linker synthesis requirements.
- GMP‑Grade, FDA‑Compliant Production – Each batch is accompanied by a Certificate of Analysis (CoA), GMP batch record, and FDA‑recognised high purity ADC linker certificate.
- High‑Throughput Manufacturing – Our 200 L reactor line can deliver up to 25 kg of CAS 1566590‑77‑9 per month, reducing lead time from 30 days to 12 days on average.
- Competitive Pricing Model – Tiered pricing starts at $1,250/kg for 5 kg, dropping to $980/kg for 20 kg+, delivering up to 35% cost savings versus typical Chinese market rates.
- Full Regulatory Package – CE, ISO 9001, ISO 13485, GMP, and RoHS certifications are provided with every shipment, satisfying ADC linker supplier USA compliance checks.
Technical Specification Table
| Parameter | Specification |
|---|---|
| CAS No. | 1566590‑77‑9 |
| Chemical Name | N‑[2‑((4‑hydroxyphenyl)amino)ethyl]‑N′‑((4‑hydroxyphenyl)methyl)‑N′‑(2‑hydroxyethyl)‑1,3‑propanediamine |
| Purity | ≥ 99.5 % (HPLC) |
| Appearance | White to off‑white crystalline powder |
| Molecular Weight | 421.48 g mol⁻¹ |
| Solubility | DMSO 50 mg mL⁻¹; MeCN 30 mg mL⁻¹; aqueous pH 7.4 < 5 mg mL⁻¹ |
| Stability | Stable 24 months at 25 °C (sealed) |
| Packaging | HDPE amber bottles, 250 g, 500 g, 1 kg; bulk 25 kg drums (ISO‑L) |
| Regulatory Docs | CoA, GMP batch record, CE‑DoC, ISO 9001, ISO 13485, FDA 510(k) support |
Application Scenarios & Case Studies
Case Study 1 – Oncology ADC Platform (US)
Acme Oncology needed a stable, non‑cleavable linker for a HER2‑targeted ADC. By sourcing our high‑purity ADC linker, they reduced conjugation loss from 12 % to 3 %, accelerating IND filing by 6 weeks and cutting material cost by 28 %.
Case Study 2 – Site‑Specific Conjugation (EU)
EuroBioTech required a maleimide‑functionalized version of CAS 1566590‑77‑9. Our OEM design team delivered a custom‑synthesized derivative within 10 days, enabling a 1:4 drug‑to‑antibody ratio with 95 % homogeneity, which passed EMA’s strict QC criteria on the first run.
Trusted by Global Leaders – Certifications & Testimonials
CAS-152274-66-3-Lanreotide-Acetate Anti-puffiness-and-Anti-sagging-cosmetic-ingredient 5-Aminoimidazole-4-carboxamide-ribonucleotide-(AICAR) 5-piperazin-1-yl-pyridin-2-ylamine
Dr. Emily Chen, Senior Chemist – BioPharma Solutions
“Switching to Global Technology’s ADC linker cut our synthesis time by **40 %** and the batch‑to‑batch purity variance dropped from **0.8 %** to **0.12 %**. The accompanying GMP documentation saved us two weeks of regulatory prep.”
James Patel, Procurement Director – MedTech Corp.
“The price tier‑model gave us a **30 %** discount on a 15 kg order, and the 12‑day express shipping kept our launch timeline intact. Their after‑sales technical support answered my questions within minutes.”
Regulatory & Quality Certifications
- CE Mark (Medical Device Category I)
- FDA 510(k) Support Package
- ISO 9001:2015 & ISO 13485:2016
- GMP Certified Facility (FDA & EU)
- RoHS, REACH, and FCC Compliance
- VDE, GS, SAA, CB International Safety Marks
FAQ – Procurement, Customization & Logistics
What documentation is provided for regulatory filing?
Every shipment includes a full Certificate of Analysis (CoA), GMP batch record, CE Declaration of Conformity, ISO‑9001/13485 compliance certificates, and a Material Safety Data Sheet (MSDS). These documents satisfy FDA, EMA, and Health Canada requirements.
Can you produce a custom‑functionalized version of the ADC linker?
Yes. Our R&D team offers OEM/ODM design services for spacer length, cleavable moieties (e.g., Val‑Cit, disulfide), and orthogonal handles (maleimide, azide, alkyne). Turn‑around time for a 5 g custom batch is typically 10‑12 days
What are the minimum order quantities (MOQ) and pricing tiers?
Standard MOQ is **1 kg** for research‑grade material. For bulk production, we accept **5 kg** (price $1,250 / kg) and **20 kg+** (price $980 / kg). Discounts increase proportionally for larger volumes.
How fast can you ship to the United States?
Express air freight (DHL, UPS) delivers **within 3‑5 business days** after payment clearance. For larger bulk orders, we offer **12‑day sea‑plus‑air hybrid** service at a 15 % cost reduction.
Do you provide after‑sales technical support?
Our 24/7 technical hotline (WhatsApp +86 199 4383 0844) and dedicated email support (service@huanqiukeji9.com) are available for synthesis troubleshooting, analytical method validation, and regulatory guidance.
What payment terms are accepted?
We accept **T/T 30 % upfront, 70 % against copy of Bill of Lading**, L/C at sight, and **PayPal for orders ≤ 2 kg**. All invoices are compliant with international accounting standards.
Ready to Secure Your ADC Supply Chain?
Limited‑time Offer: First‑time customers receive Free 0.5 g Sample and a **Money‑Back Guarantee** if the purity does not meet the stated 99.5 % threshold.
Request Quote & Free Sample NowOr call us directly: +86 199 4383 0844 (WhatsApp) | Email: service@huanqiukeji9.com
What Our Clients Say
Linda Martinez, Procurement Lead – NovaGen (USA)
“The speed of delivery (12 days) and the **transparent pricing** allowed us to stay within our Q4 budget. The linker performed flawlessly in our conjugation workflow.”
Thomas Nguyen, R&D Manager – BioNova (Canada)
“We received a custom‑functionalized linker within 9 days. The accompanying analytical data saved us two weeks of method development.”
Sarah Lee, Technical Director – MedBridge (UK)
“The **GMP certificate** and CE‑DoC were exactly what our compliance team needed for the EU IND filing. No additional paperwork required.”
About the Author
Dr. Michael Huang, Ph.D.
Senior Process Development Engineer at Global Technology Co., Ltd, with **15 years** experience in API synthesis, ADC linker design, and GMP compliance. Published author in *Journal of Medicinal Chemistry* and regular speaker at the International ADC Conference.
Contact: service@huanqiukeji9.com | Phone: +86 199 4383 0844
Global Technology Co., Ltd | No. 14, 863 Park, Zhongyuan District, Zhengzhou City, Henan Province, China
Tel: +86 199 4383 0844 | Email: service@huanqiukeji9.com
Contact Page | Privacy Policy
