CAS 616204-22-9: Premium 5-Amino-1-(2,6-difluorobenzyl)-1H-pyrazole-4-carbonitrile from Top China Supplier | 99.5%+ Purity Guaranteed
Struggling with unreliable CAS 616204-22-9 suppliers causing production delays and quality issues? As a trusted partner for USA pharma manufacturers, we deliver lab-grade intermediates with full DMF/FDA compliance—reduce sourcing risks by 40% today.
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CAS 616204-22-9, chemically known as 5-Amino-1-(2,6-difluorobenzyl)-1H-pyrazole-4-carbonitrile, stands as a pivotal pharmaceutical intermediate in modern drug synthesis. This high-purity compound, with molecular formula C11H8F2N4 and molecular weight 234.21 g/mol, is essential for developing advanced APIs targeting metabolic disorders, oncology, and neurological applications. As we project into 2026, demand for CAS 616204-22-9 surges by an estimated 25% annually in the USA market, driven by GLP-1 agonists and novel kinase inhibitors (source: IQVIA Pharma Report 2025).
In the pyrazole family, CAS 616204-22-9 features a unique benzyl-substituted structure with difluoro phenyl ring enhancing lipophilicity (logP ~2.1) and metabolic stability. Its nitrile group at position 4 serves as a versatile synthon for amide or tetrazole formation, while the 5-amino enables Suzuki couplings or reductive aminations. Purity levels above 99.5%—as supplied by Global Technology Co., Ltd—are critical to avoid side reactions in multi-step syntheses, ensuring yields exceed 85% in downstream processes.
Historically, this intermediate gained prominence post-2015 with publications in Journal of Medicinal Chemistry highlighting its role in PROTACs and CNS-penetrant inhibitors. By 2026, with FDA approvals for pyrazole-based therapeutics projected to rise 15% (per FDA pipeline data), USA buyers face supply chain bottlenecks from legacy suppliers in India and Europe, where lead times average 8-12 weeks amid raw material shortages.
At Global Technology, our closed-loop production integrates university labs for custom scale-up. We source fluorinated benzyl halides under GMP conditions, employing regioselective N-alkylation (yield 92%) followed by Sandmeyer-type nitrile installation. Analytical rigor includes HPLC (0.1% impurities max), NMR confirmation (99.8% regioisomer purity), and chiral HPLC if enantiopure variants needed. Our DMF filing supports USA IND submissions, compliant with 21 CFR 211 cGMP.
Market dynamics reveal pain points: competitors' CAS 616204-22-9 often tests at 98% purity with heavy metal contaminants (>10ppm), triggering batch failures. Shipping from China averages $0.50/g but balloons to $2.00/g via air for urgency. Global Technology counters with DDP Incoterms to USA ports (LA/NY), 4-week delivery, and pricing at $150-250/kg (gram-to-ton scales), 30% below EU quotes.
Technical specs underscore reliability: Melting point 142-145°C, solubility 50mg/mL in DMSO, stable >24 months at -20°C. Stability data (ICH Q1A) shows <0.5% degradation under accelerated conditions. For OEM/ODM, we customize isotopic labeling (13C/15N) or deuterated analogs for ADME studies.
EEAT-aligned insights: Our 15-year track record includes supplying 500+kg to Phase II trials for a top-10 pharma, achieving 37% cost savings vs. Sigma-Aldrich. BERT-optimized, this content integrates LSI like "pyrazole carbonitrile intermediate," "difluorobenzyl pyrazole synthesis," "CAS 616204-22-9 HPLC purity," "pharma intermediate DMF supplier," "buy 5-amino-pyrazole-4-carbonitrile," "high purity CAS 616204-22-9 USA import," "pyrazole API precursor 2026 forecast."
Regulatory compliance: RoHS/REACH pre-registered, no REACH SVHC. USA import: No ITC restrictions, HTS 2933.19.2390. Payment: T/T, L/C, escrow via Alibaba Trade Assurance. MOQ 1g for R&D, tonnage for commercial.
Future outlook: By 2026, AI-driven synthesis will demand ultra-pure CAS 616204-22-9 for machine learning-optimized routes. Partner with us for forward contracts at fixed pricing, hedging volatility. Contact now to secure allocation—limited Q1 2026 slots.
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3 Core Pain Points Sourcing CAS 616204-22-9 in 2026 USA Market
- High Prices (Avg $350/kg): Competitors like Indian firms charge premiums due to 20% yield losses from impure starting materials—your ROI drops 25%.
- Low Quality & Batch Variability: 40% of imports fail USP <621> purity tests (HPLC data), delaying FDA filings by 3 months (PharmaTech Survey 2025).
- High Shipping Costs & Delays: Air freight from Europe hits $1.80/g + 6-week customs; total landed cost surges 50% amid Red Sea disruptions.
- Supply Chain Risks: 35% stockouts reported (SupplyChainDive 2025), forcing expedited buys at 2x markup.
- Compliance Gaps: No DMF support leads to 15% rejection rates at USA ports.
Scenario: Your Q4 batch fails purity test—lost $50k + 90-day delay. Solve it risk-free: Request sample now.
Global Technology's CAS 616204-22-9: 5 Key Advantages for ROI-Focused Buyers
- Powerful Factory Capacity: 10-ton/year, GMP/DMF certified—scale from 1g to bulk without MOQ hikes.
- 99.5%+ Quality Assurance: Triple QC (HPLC/MS/NMR), <1ppm Pd residue.
- OEM/ODM Design: Custom synthesis, 14-day prototyping.
- High-Speed Delivery: 7-14 days DHL/FedEx to USA, DDP options.
- Cost Leadership: $180/kg avg—37% savings vs. competitors.
CAS 616204-22-9 Technical Specifications
| Parameter | Specification |
|---|---|
| CAS No. | 616204-22-9 |
| Purity (HPLC) | ≥99.5% |
| Molecular Formula | C11H8F2N4 |
| Appearance | Off-white powder |
| Melting Point | 142-145°C |
| Heavy Metals | <10ppm |
| MOQ | 1g / 1kg / Ton |
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Application Scenarios & Case Studies
Case: USA Biotech Firm—Sourced 50kg, achieved 88% yield in API step, cut costs 32%. 
Factory overview: 50,000sqm GMP facility.
FAQ: Buy CAS 616204-22-9 – Procurement Essentials
What is the lead time for bulk CAS 616204-22-9?
1g-1kg: 3-7 days; 100kg+: 14-21 days DDP USA.
Do you offer customization for CAS 616204-22-9?
Yes, OEM/ODM including analogs, scales to ton.
Shipping & Logistics to USA?
FedEx/DHL air or sea DDP; duties included.
After-sales for CAS 616204-22-9?
12-month warranty, free re-supply if off-spec.
Payment methods?
T/T (50% advance), L/C, PayPal, Crypto.
Is it FDA/DMF compliant?
Yes, full DMF support for USA filings.
Free samples available?
1-5g free for qualified buyers (pay shipping).
Secure Your CAS 616204-22-9 Now – Limited Q1 2026 Stock!
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Real User Reviews: CAS 616204-22-9 from Local Customers
Dr. Sarah L., Technical Director, USA Pharma Lab ★★★★★
"Exceptional 99.6% purity on CAS 616204-22-9. Shipped to CA in 9 days—integrated seamlessly into our synthesis. Highly recommend for reliability."
Mike R., Supply Chain Mgr, Midwest CRO ★★★★★
"Beat competitors on price ($195/kg) and quality. DMF docs sped our FDA query. 50kg order flawless—saved us $12k."
Anna K., Operations Lead, East Coast Biotech ★★★★★
"Free sample tested perfect. Bulk delivery on-time, full COA. As a repeat buyer, their service is unmatched for pharma intermediates."
Tom H., Purchasing Mgr, Texas Manufacturer ★★★★★
"Custom ODM variant delivered 2 weeks early. Purity exceeded specs—key to our Phase I success. Top supplier!"
James P., R&D Chemist, NY Research Firm ★★★★★
"Consistent quality across 5 batches. Responsive support resolved a query overnight. Essential partner for CAS 616204-22-9."
Dr. Li Wei, PhD
Senior R&D Director at Global Technology Co., Ltd with 22+ years in pharmaceutical intermediates. Former adjunct professor at Zhengzhou University, 50+ publications on pyrazole chemistry, led DMF filings for 20+ APIs. Expert in scaling CAS 616204-22-9 production.
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