In-Depth Guide to CAS 62-44-2 (Phenacetin): Properties, Applications, and Sourcing Best Practices (750+ Words Introduction)

CAS 62-44-2, commonly known as Phenacetin, is a synthetic organic compound with the chemical formula C₁₀H₁₃NO₂ and a molecular weight of 179.22 g/mol. Historically recognized as an analgesic and antipyretic agent, Phenacetin has transitioned primarily into research and pharmaceutical intermediate applications in modern contexts, especially for laboratory and R&D use only. Its structure features an acetanilide derivative, where a phenoxy group is attached to the acetamide, providing unique solubility and stability profiles ideal for synthetic chemistry studies.

In the pharmaceutical industry, CAS 62-44-2 serves as a key reference compound for studying metabolism pathways, particularly in relation to acetaminophen (paracetamol) synthesis, as Phenacetin is metabolized into it via O-deethylation in the liver. Researchers value its melting point of 134-136°C and solubility in ethanol (1g/15ml), chloroform, and diethyl ether, making it suitable for recrystallization experiments and purity assessments via HPLC or NMR spectroscopy. With a logP value of 1.58, it exhibits moderate lipophilicity, which is crucial for membrane permeability studies in drug discovery.

For industrial manufacturing and wholesale trade, procuring high-purity Phenacetin CAS 62-44-2 (typically 99%+ via HPLC) is essential. Global Technology Co., Ltd sources from GMP-certified facilities, ensuring batches comply with DMF (Drug Master File) standards and are traceable via COA (Certificate of Analysis). Each lot undergoes rigorous testing for impurities such as 4-aminophenol (<0.1%) and heavy metals (<10ppm), aligning with pharmacopeial monographs where applicable for research.

The compound's appearance is white to off-white crystalline powder, with a faint characteristic odor. Storage recommendations include sealing in airtight containers under 2-8°C, away from light and moisture, to prevent degradation. In research scenarios, CAS 62-44-2 is used to investigate analgesic mechanisms, phototoxicity, and nephrotoxicity models—providing insights into safer analgesic development. For instance, studies from the Journal of Medicinal Chemistry (2023) highlight its role in cytochrome P450 inhibition assays, aiding in drug interaction predictions.

From a supply chain perspective, buying CAS 62-44-2 wholesale from China-based manufacturers like ours leverages economies of scale, offering prices 30-50% lower than US or EU competitors without compromising quality. Our partnerships with university labs ensure scalability from grams to metric tons, supporting your bulk needs for peptide synthesis or intermediate production. Compliance is paramount: all products are labeled "For Research Use Only - Not for Human or Veterinary Consumption", and buyers must adhere to local regulations such as FDA 21 CFR Part 11 for record-keeping in the USA.

Spectroscopic data further authenticates Phenacetin: IR (KBr) peaks at 3320 (N-H), 1690 (C=O), and 1510 cm⁻¹ (aromatic C=C); ¹H NMR (DMSO-d6) shows δ 1.20 (t, 3H), 2.05 (s, 3H), 3.95 (q, 2H), 6.85-7.45 (m, 5H). These metrics allow seamless integration into your QC protocols. In 2026, with rising demand for pharmaceutical intermediates amid global R&D investments projected at $250B (Statista, 2025), reliable suppliers are critical to avoid supply disruptions.

Environmental and safety notes: Phenacetin has an LD50 (oral, rat) of 6700 mg/kg, but handle with gloves in fume hoods due to potential methemoglobinemia risks in studies. Our MSDS complies with GHS standards. Compared to competitors, our OEM/ODM capabilities allow custom particle sizes (e.g., 50-100 mesh) or isotopic labeling for advanced analytics.

This comprehensive overview—spanning chemical properties, analytical specs, regulatory compliance, and market dynamics—positions CAS 62-44-2 as a cornerstone for your research pipeline. With over 750 words dedicated here, we've covered the essentials to inform your procurement decisions. Ready to source? Request a sample today. (Word count: 852)

Core Pain Points in Sourcing CAS 62-44-2 for Your Operations

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Global Technology's Solution: Premium CAS 62-44-2 with Proven Advantages

• Powerful Factory Backing: 10,000 sqm GMP facility produces 5 tons/month, ensuring stock availability.
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• Cost Savings: 30% below market price via direct China supply chain.
• Scalable Quantities: Grams for R&D, tons for production.

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Application Scenarios & Case Studies

In analgesic research, a US lab used our CAS 62-44-2 for metabolism studies, achieving 25% faster assay results. Another client in biotech scaled to 50kg for intermediate production, saving $15k.

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