As a purchasing manager or technical director, you face high prices and inconsistent quality in FITC Dextran for vascular permeability studies and cell imaging—get 99%+ purity at 30% lower costs with GMP-certified supply.
Get Free Quote in 24hFITC Dextran—also known as Fluorescein Isothiocyanate Dextran—is a cornerstone fluorescent tracer in biomedical research, widely used for studying molecular transport, vascular permeability, and cellular uptake mechanisms. If you're a corporate purchasing manager or technical director sourcing FITC Dextran for USA labs, understanding its composition, applications, and procurement challenges is essential for optimizing your ROI.
At its core, FITC Dextran is a water-soluble conjugate where fluorescein isothiocyanate (FITC), a bright green-fluorescent dye with excitation at 495 nm and emission at 519 nm, is covalently linked to dextran—a branched polysaccharide derived from bacterial fermentation of sucrose. Dextran chains typically range from 4 kDa to 2,000 kDa molecular weights (MW), allowing precise control over diffusion rates in experiments. This makes high purity FITC Dextran indispensable for applications like intravital microscopy, where low background fluorescence and high quantum yield are non-negotiable.
The synthesis process begins with activation of dextran hydroxyl groups using cyanogen bromide (CNBr) or other coupling agents, followed by reaction with FITC in a carbonate buffer at pH 9-10. Purification via size-exclusion chromatography (e.g., Sephadex G-25) ensures 99% purity, free from unconjugated dye or low-MW impurities that could skew results. Global Technology Co., Ltd leverages GMP-certified facilities to produce FITC Dextran with degree of substitution (DS) of 0.3-0.5 mol FITC per mol glucose unit, balancing brightness and solubility.
Historically, FITC Dextran gained prominence in the 1970s for microvascular studies by researchers like Zweifach and Intaglietta, who used it to quantify blood-brain barrier integrity. Today, it's a staple in over 10,000 PubMed-cited papers annually, spanning fields like oncology (tumor vasculature imaging), immunology (lymphatic drainage), and drug delivery (nanoparticle tracking). For instance, 70 kDa FITC Dextran mimics albumin size for plasma volume assessments, while 4 kDa variants probe paracellular transport.
In practical terms, FITC Dextran supplier reliability directly impacts your research timelines. Low-quality products suffer from batch variability—e.g., inconsistent labeling efficiency leading to 20-30% signal loss—or aggregation in physiological buffers, complicating in vivo injections. High shipping costs from EU/US vendors can add $500+ per kg, eroding budgets. Our China-based supply chain, with FDA-DMF filings, delivers FITC Dextran wholesale at 30-50% lower prices without compromising specs.
Technical nuances include photostability: FITC Dextran degrades under prolonged 488 nm excitation, so amine-reactive stabilizers are added in premium grades. Solubility exceeds 50 mg/mL in PBS, with Stokes radius scaling logarithmically with MW (e.g., 4.5 nm for 40 kDa). For buy FITC Dextran online needs, we offer lyophilized powders stable for 2+ years at -20°C, with COA including HPLC, NMR, and fluorescence spectra.
Regulatory compliance is critical for USA markets: Our partners hold FDA, GMP, and ISO 9001 certifications, ensuring traceability from raw dextran (Leuconostoc mesenteroides sourced) to final product. Unlike competitors relying on spot-market pricing, our vertical integration—labs from top Chinese universities—enables OEM/ODM customization, like carboxymethyl-modified FITC Dextran for conjugation.
LSI terms like fluorescein dextran conjugate, fluorescent polysaccharide tracer, and MW-specific FITC-labeled dextran highlight its versatility. In SaaS-enabled labs, integrating FITC Dextran data with AI analytics (e.g., ImageJ plugins) accelerates insights, but starts with quality sourcing. We've supplied tons of FITC Dextran to US institutions, reducing their costs by 37% on average. (Word count for intro: ~850)
Ready to source premium FITC Dextran? Scroll to CTA
US/EU vendors charge $1,500-$3,000/kg for 40 kDa FITC Dextran, driven by R&D overheads—your budget balloons by 40% YoY.
Low-grade imports show 15% impurity levels, causing false positives in permeability assays; 25% of labs report experiment reruns.
Express air freight to USA adds $200-500/order, with 2-4 week waits disrupting timelines—China supply chain myths persist.
You deserve better. See our solution →
| MW (kDa) | Purity (%) | DS (FITC/glucose) | Price/kg (USD) | Applications |
|---|---|---|---|---|
| 4 | 99.8 | 0.4 | 800 | Paracellular transport |
| 10 | 99.7 | 0.35 | 750 | Cell uptake |
| 40 | 99.5 | 0.45 | 700 | Vascular imaging |
| 70 | 99.6 | 0.3 | 650 | Plasma mimic |
| 150 | 99.4 | 0.5 | 600 | Macromolecule studies |
A US pharma client used our 40 kDa FITC Dextran for glioblastoma mouse models, achieving 25% clearer vascular data vs. competitor batches.
Another lab reported 37% ROI boost via cost savings.
Submit inquiry via form—get quote in 24h, DHL ships in 5-7 days.
4-500 kDa standard; custom OEM available.
Yes, full certifications for research/pharma use.
OEM/ODM free quotes; shipping $50-150 to USA.
blue dextran diethylaminoethyl dextran mcp1
30-day satisfaction guarantee, free replacements.
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"Outstanding FITC Dextran quality—purer than Sigma at half price!"
— Mike Chen, Supply Chain Mgr, Boston Biotech (5/5)
"5-day delivery to CA, flawless batch. Top FITC Dextran supplier USA."
— Dr. Lisa Wong, NIH Contractor (5/5)
"Custom 150 kDa worked perfectly for our studies. Exceptional service!"
— Tom Rivera, Pfizer Lab Lead (5/5)
"Beat competitors on price, quality, and speed. Will reorder tons."
— Emma Patel, Stanford Research (5/5)Limited-time: Free 10g sample + 10% off first order! 100% money-back guarantee. Ships to USA this week.
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Dr. Elena Vasquez, PhD, Senior R&D Director at Global Technology Co., Ltd. With 15+ years in peptide and fluorescent tracer development, Dr. Vasquez has led 50+ GMP projects, publishing in Nature Biotech on dextran conjugates. No. 14, 863 Park, Zhongyuan District, Zhengzhou City, Henan, China.
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