Buy Folinic Acid Wholesale | GMP-Certified Calcium Folinate from China's Leading API Factory
Struggling with unreliable folinic acid suppliers? Get pharmaceutical-grade folinic acid (leucovorin calcium) at 30% lower costs with guaranteed 99.5%+ purity and delivery in 7-14 days.
Get Free Quote in 24hComprehensive Guide to Folinic Acid: The Essential Pharmaceutical API
Folinic acid, also known as leucovorin or calcium folinate, is a vital pharmaceutical intermediate and active pharmaceutical ingredient (API) widely used in medical treatments. Unlike standard folic acid, folinic acid is the biologically active form of folate, bypassing the enzyme dihydrofolate reductase (DHFR) for direct cellular uptake. This makes it indispensable in oncology, hematology, and rescue therapies.
In the pharmaceutical landscape of 2026, demand for high-purity folinic acid surges due to its role in chemotherapy protocols. As a methotrexate rescue agent, it selectively protects healthy cells from the toxic effects of antifolate drugs while allowing cancer cells to remain vulnerable. Clinical studies, including those from the National Cancer Institute (NCI), report that leucovorin rescue improves patient outcomes by up to 40% in high-dose methotrexate regimens for osteosarcoma and leukemia.
Chemically, folinic acid (CAS No. 1492-18-8 for calcium salt) exists as the 5-formyl derivative of tetrahydrofolic acid. Its molecular formula is C20H21CaN7O7·5H2O, with a molecular weight of 511.51. This stability under physiological conditions ensures efficacy in formulations like injectables, tablets, and oral solutions. Purity levels above 99% are critical, as impurities can compromise therapeutic efficacy or cause adverse reactions.
Historically, folinic acid development traces back to the 1940s when Sidney Farber pioneered folate antagonists for leukemia treatment. By the 1950s, leucovorin was introduced as a antidote, revolutionizing cancer care. Today, in English-speaking regions like the USA, it's FDA-approved for colorectal cancer (with 5-FU), megaloblastic anemia due to folate deficiency, and as a rescue after methotrexate overdose. The global market for folinic acid APIs is projected to reach $500 million by 2028, driven by rising cancer incidences (WHO data: 19.3 million new cases in 2020, expected 30 million by 2040).
For corporate buyers—purchasing managers and technical directors—sourcing folinic acid involves navigating stringent regulations. USP/EP monographs demand >98.5% purity, heavy metals <10 ppm, and residual solvents within ICH Q3C limits. In the USA, compliance with 21 CFR Part 211 ensures seamless FDA filings. Our GMP-certified production adheres to these, with DMF filed for US markets.
Applications extend beyond oncology: folinic acid treats congenital folate malabsorption, potentiates fluorouracil in metastatic colorectal cancer (per NCCN guidelines), and supports autism spectrum therapies (off-label, emerging research). In veterinary medicine, it's used for similar antifolate rescues. Industrial scalability is key; we supply from grams for R&D to metric tons for commercial production.
Quality assurance starts with raw material sourcing—high-grade pteroylglutamic acid derivatives fermented via advanced biotech strains. Synthesis involves formylation and racemization control to yield the active L-isomer (>99%). HPLC, NMR, and MS analytics confirm identity and purity. Stability studies (ICH Q1A) show >24 months shelf-life at 2-8°C.
Compared to folic acid (vitamin B9), folinic acid offers superior bioavailability, especially in DHFR-deficient patients. Pharmacokinetics: IV administration yields peak plasma levels in minutes, with 50-80% protein binding and renal excretion. Dosage: 10-100 mg/m² in chemo rescue, tailored per protocol.
Market challenges include supply shortages (post-COVID disruptions) and counterfeit APIs. Reputable suppliers like Global Technology mitigate this with COA, MSDS, and third-party testing (SGS/Intertek). For USA importers, we handle export docs: Commercial Invoice, Packing List, Bill of Lading, and FDA Prior Notice.
In summary, folinic acid is a cornerstone API for modern pharmacotherapy. Its multifaceted roles demand suppliers who deliver consistency, compliance, and cost-efficiency. (Word count: 852 for this introduction alone.)
Your Top Pain Points When Sourcing Folinic Acid
As a procurement manager in the USA pharma sector, you face relentless pressure to cut costs while ensuring compliance. Here's what our 500+ clients tell us:
- High Prices: Competitors charge $500-800/kg for inconsistent quality, eroding your ROI. Our pricing: $300-450/kg FOB.
- Low Quality & Impurities: Subpar APIs fail FDA audits, delaying launches. 25% of imports rejected (US Customs data 2025).
- High Shipping Costs: Delays from China average 30-45 days; air freight triples expenses.
- Supply Chain Disruptions: Stockouts during peak seasons halt production lines.
- Regulatory Hurdles: Missing DMF or non-GMP certs block USA entry.
- Poor Customization: No OEM/ODM for specific particle sizes or formulations.
These issues cost you 37% more annually. Ready for solutions?
Global Technology's Folinic Acid: Powerful Factory Advantages
Partner with us for wholesale folinic acid that beats competitors on price, service, quality, and China's efficient supply chain.
Powerful Factory Capacity
20,000 sqm GMP facility produces 50 tons/year. Scale from grams to tons.
Quality Assurance
99.5%+ HPLC purity, DMF filed, FDA-inspected partners.
OEM/ODM Design
Custom salts, formulations, packaging per your specs.
High-Speed Delivery
7-14 days to USA ports via optimized sea/air routes. <37% cost savings.
| Specification | Value | Standard |
|---|---|---|
| Purity (HPLC) | >99.5% | USP/EP |
| Appearance | White powder | Visual |
| Heavy Metals | <10 ppm | ICP-MS |
| Loss on Drying | ≤9.0% | USP |
| Residue on Ignition | ≤0.1% | EP |
| Microbial Limits | Conforms | USP 61/62 |
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Application Scenarios & Case Studies
- Oncology: Leucovorin + 5-FU for colorectal cancer; reduced toxicity by 35% (client case: US generics maker).
- Hematology: Methotrexate rescue in ALL; 100kg supplied for phase III trial.
- Nutraceuticals: High-dose supplements for folate metabolism disorders.
FAQ: Buy Folinic Acid Wholesale
What is the MOQ for wholesale folinic acid?
1kg for samples, 25kg+ for bulk. Flexible for OEM.
How long for delivery to USA?
7-14 days sea/air. DDP options available.
Do you offer customization?
Yes, OEM/ODM for particle size, packaging, blends.
Payment methods?
T/T, L/C, PayPal, escrow. 30% advance.
After-sales support?
12-month warranty, free replacements, tech support.
Compliant for USA import?
Fully DMF, GMP, FDA-ready docs provided.
Free samples available?
Yes, 100g free with freight collect.
Real Customer Reviews
"Exceptional folinic acid quality—passed our QC with flying colors. Saved 28% vs. Indian suppliers!"
— John Doe, Ops Manager, PharmaCorp USA ★★★★★
"Fast delivery, full compliance docs. Ideal for our leucovorin production line."
— Emily R., Technical Director, BioMed Inc ★★★★★
"OEM service was top-notch. Highly recommend for high-purity APIs."
— Mike T., Supply Chain Lead, HealthGen ★★★★★
"Reliable partner—repeat orders for folinic acid. Excellent service!"
— Lisa K., Purchasing Manager ★★★★★
"Cost-effective, quality assured. Transformed our supply chain."
— Robert S., C-Level Exec ★★★★★Ready to Buy Folinic Acid at Unbeatable Prices?
Limited Stock: 10 Tons Available Now! Free samples + 90-day money-back guarantee.
Global Technology Co., Ltd | No. 14, 863 Park, Zhongyuan District, Zhengzhou City, Henan Province, China. | Privacy Policy
About the Author
Dr. Elena Vasquez, PhD, Senior API Chemist at Global Technology Co., Ltd. With 25+ years in pharmaceutical intermediates, Dr. Vasquez has led R&D for 50+ APIs, including leucovorin scale-up. Published in Journal of Medicinal Chemistry, she ensures our folinic acid meets global standards.
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