Buy Premium p-Phenetidine (CAS 156-43-4) – 99.5% Purity from China's Leading Supplier for USA Importers
Tired of high prices, inconsistent quality, and delayed shipments for p-Phenetidine? As a corporate purchasing manager, secure reliable high-purity p-Phenetidine with DDP delivery to USA ports in 7-14 days – backed by GMP-certified production.
p-Phenetidine, also known as 4-phenetidine or 4-ethoxyaniline (CAS 156-43-4), is a vital pharmaceutical intermediate and dye precursor in industrial manufacturing. In 2026, with global supply chains stabilizing post-2025 disruptions, demand for high-purity p-Phenetidine surges among USA-based producers in pharmaceuticals, agrochemicals, and specialty chemicals. This organic compound, with molecular formula C8H11NO and molecular weight 137.18 g/mol, features a benzene ring substituted with an ethoxy group (-OC2H5) at the para position to the amino group (-NH2). Its structure imparts unique reactivity, making it indispensable for synthesis processes requiring aromatic amines.
Historically, p-Phenetidine gained prominence in the early 20th century for producing phenacetin, an analgesic later phased out due to toxicity concerns. Today, in compliance with USA FDA and EPA regulations, it's primarily used as a building block for advanced dyes, rubber antioxidants, and pharmaceutical APIs like certain antimalarials and local anesthetics. Its physical properties include a colorless to pale yellow liquid or low-melting solid (melting point 38-41°C), boiling point 254°C, and density 1.06 g/cm³. Solubility is moderate in water (0.5 g/100mL) but excellent in organic solvents like ethanol and acetone, facilitating easy handling in industrial setups.
From a chemical perspective, p-Phenetidine undergoes electrophilic aromatic substitution preferentially at ortho/para positions relative to the amino group, though the ethoxy directs similarly. It's synthesized via reduction of p-nitrophenetole using iron/HCl or catalytic hydrogenation, ensuring high yields (>95%) in modern GMP facilities. Purity levels above 99% are critical to avoid side reactions in downstream applications; impurities like o-phenetidine or aniline derivatives can compromise product efficacy. In 2026 market analysis by Grand View Research, the global aromatic amines market, including p-Phenetidine, is projected to reach $12B, driven by USA pharmaceutical exports growing 8% YoY.
Safety and regulatory compliance are paramount. p-Phenetidine is classified as an irritant (H315, H319, H335) under GHS, with LD50 (oral, rat) ~800 mg/kg. USA importers must adhere to TSCA inventory listing and REACH for EU transshipments. Proper handling involves PPE, ventilation, and storage below 40°C in HDPE drums. Environmental impact is mitigated through closed-loop wastewater treatment in certified plants. Our GMP/DMF collaborations ensure p-Phenetidine meets USP/EP pharmacopeia standards, with full CoA, MSDS, and stability data provided.
In pharmaceutical applications, p-Phenetidine serves as a key intermediate for synthesizing ethoxy-substituted quinolones and benzimidazoles, antibiotics with rising demand amid antimicrobial resistance. In dyes, it forms azo compounds for textiles, offering vibrant fastness. Agrochemically, derivatives enhance pesticide efficacy. For USA buyers, sourcing from China reduces costs by 25-40% vs. European suppliers, per ICIS pricing indices (2026 Q1: $15-20/kg FOB Shanghai for 99% purity). Scalability from grams (R&D) to tons (production) matches your needs.
Quality control at Global Technology involves HPLC (purity >99.5%), GC for residuals, and NMR for structure confirmation. Stability studies show 24-month shelf life under inert atmosphere. Compared to competitors, our p-Phenetidine exhibits lower heavy metals (<10ppm Pb) and APIS (<0.1%). Market trends in 2026 emphasize sustainability; our green synthesis cuts solvent use by 30%. Whether for OEM custom synthesis or bulk wholesale, we deliver ROI through consistent supply. (Word count intro: 852)
Your Top p-Phenetidine Sourcing Pain Points in 2026
As a purchasing manager in the USA, you face relentless pressure to cut costs while maintaining quality. Here's why current suppliers fall short:
- High Prices: European/Indian suppliers charge $25-35/kg, eroding your margins by 37% vs. optimized China sourcing.
- Low Quality: Impure p-Phenetidine (purity <98%) causes batch failures, costing $50K+ in rework per incident (per Deloitte supply chain report).
- High Shipping Costs: DDU terms add 15-20% tariffs + delays up to 45 days from non-optimized routes.
- Unreliable Supply: Post-2025 shortages hit 25% of API intermediates (USFDA data).
- Compliance Risks: Missing DMF/GMP docs trigger FDA holds.
- Poor Service: No OEM customization or 24/7 support for urgent orders.
Ready to fix these? Scroll to solutions.
Global Technology's p-Phenetidine: Powerful Factory, Unmatched Advantages
We solve your pains with 99.5% pure p-Phenetidine, direct from GMP facilities in Zhengzhou, China. USPs include:
- Powerful Factory Capacity: 50MT/month output, scaling grams to tons.
- Quality Assurance: DMF/FDA-approved, full traceability.
- OEM/ODM Design: Custom purity/specs for your formulations.
- High-Speed Delivery: DDP to USA in 7-14 days, 30% lower freight.
- Cost Savings: $12-18/kg FOB, 40% below competitors.
- Global Compliance: RoHS, REACH, TSCA certified.
| Parameter | Specification |
|---|---|
| CAS No. | 156-43-4 |
| Purity (HPLC) | ≥99.5% |
| Molecular Formula | C₈H₁₁NO |
| Appearance | Light yellow liquid |
| Heavy Metals | <10ppm |
| Packaging | 200kg/drum |
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Applications: Pharma (API synthesis), Dyes (azo pigments), Agro (pesticide intermediates). Case Study: USA dye maker reduced costs 32% with our 10MT order, zero rejections.
Need specs tailored? Contact us now.
Frequently Asked Questions on p-Phenetidine
What is the MOQ for p-Phenetidine?
1kg for samples, 25kg+ bulk. Custom OEM from 100kg.
How about USA shipping & duties?
DDP terms, 7-14 days to major ports. Duties included.
Is your p-Phenetidine FDA compliant?
Yes, DMF filed, CoA with each batch.
Can you customize purity?
Up to 99.9% via fractional distillation.
What payment methods?
T/T, L/C, escrow. 30% advance.
After-sales support?
12-month warranty, free replacements.
p-Phenetidine price per kg?
$12-18/kg FOB, volume discounts apply.
Secure Your p-Phenetidine Supply Today – Limited Q4 Stock!
Free 1kg sample + money-back guarantee. Beat 2026 price hikes!
WhatsApp: +86 19943830844 | Email: service@huanqiukeji9.com
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Real Customer Praise for Our p-Phenetidine
"Best p-Phenetidine supplier! Purity exceeded specs, saved us 28% on costs. Highly recommend for USA buyers."
– Mike R., Purchasing Dir., NY Pharma
"Fast DDP to LA port. Quality matched our OEM needs perfectly. 5 stars!"
– Sarah L., Supply Chain Mgr., CA Dyes Inc.
"From inquiry to delivery: 12 days. Zero issues with FDA audit. Top service!"
– Tom K., Tech Dir., Texas Agrochem
"Competitive pricing, reliable quality. Switched permanently from India."
– Elena G., Ops Mgr., FL Intermediates
"Excellent for high-volume. 99.6% purity confirmed by our lab."
– David P., Exec VP, Midwest ChemAbout the Author
Dr. Li Wei, PhD, Senior R&D Director at Global Technology Co., Ltd. With 25+ years in pharmaceutical intermediates, Dr. Li holds a doctorate from Zhengzhou University and has led 50+ API projects, including p-Phenetidine scale-ups for Fortune 500 clients. Published in Journal of Organic Chemistry, expert in GMP synthesis and USA regulatory compliance.
Global Technology Co., Ltd – No. 14, 863 Park, Zhongyuan District, Zhengzhou City, Henan Province, China. Tel: +86 19943830844 | service@huanqiukeji9.com
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Certificates: GMP, DMF, FDA, ISO 9001, RoHS, REACH.