![[Ala5, β-Ala8]-Neurokinin A (4-10) CAS NO.127633-71-0](https://images.cnmqh.com/images/a10134/ecf006fd7af8d7921b768725636f3a54-20260130034905.webp "[Ala5, β-Ala8]-Neurokinin A (4-10) CAS NO.127633-71-0")
[Ala5, β-Ala8]-Neurokinin A (4-10) CAS NO.127633-71-0
[Ala5, β-Ala8]-Neurokinin A (4-10) CAS NO.127633-71-0
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Ala5, β-Ala8]-Neurokinin A (4-10) |
| CAS NO. | 127633-71-0 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C35H56N8O9S |
| Molecular Weight | 765g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1 % v/v). For best results, first dissolve in a small volume of 0.1 % acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution, then dilute with the desired assay buffer. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | This analog is a modified fragment of Neurokinin A designed for structure-activity relationship (SAR) studies of tachykinin peptides. The Ala⁵ substitution may simplify the side-chain structure, while the β‑Ala⁸ introduction increases backbone flexibility, potentially altering receptor binding affinity, selectivity (primarily at NK₂ receptors), and metabolic stability compared to the native NKA(4‑10) sequence. Activity should be validated in relevant NK receptor binding or functional assays (e.g., calcium mobilization). |
| Storage Conditions | Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide acts as a tachykinin receptor ligand with potentially altered binding and signaling properties compared to native Neurokinin A. The Ala⁵ substitution reduces side-chain bulk, which may impact hydrophobic interactions with neurokinin receptors (primarily NK₂R), while the β‑Ala⁸ modification introduces increased conformational flexibility, potentially affecting receptor engagement, selectivity, and resistance to proteolytic degradation. Upon binding, it is expected to activate Gq/11-coupled pathways, leading to phospholipase C activation, IP₃ production, and calcium mobilization, though its specific agonist/antagonist profile and receptor selectivity must be empirically determined in functional assays.
2.PRODUCT INDICATIONS
This modified Neurokinin A fragment is indicated exclusively for research use in preclinical studies of tachykinin receptor pharmacology and peptide design. It is employed in structure-activity relationship studies to evaluate the effects of side-chain simplification and backbone flexibility on receptor binding affinity, selectivity, and metabolic stability. The product serves as a tool compound for screening NK receptor ligands, optimizing peptide therapeutics with improved pharmacokinetic properties, and investigating the pharmacophore requirements of tachykinin signaling. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent for SAR studies, [Ala⁵, β‑Ala⁸]‑Neurokinin A (4‑10) has no established clinical efficacy for therapeutic use in human patients. The product has not undergone clinical development, regulatory approval, or safety evaluation for any medical indication. While it contributes to the understanding of tachykinin receptor pharmacology and peptide design principles, particularly regarding the impact of backbone flexibility on ligand properties, it remains an investigational tool for basic research. Its utility is confined to laboratory applications, with no proven clinical benefits or safety profile in humans.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Nov 05, 26
Global Market Analysis and Oxandrolone 50mg Price Guide
For B2B pharmaceutical buyers and researchers, understanding the oxandrolone 50mg price involves analyzing more than just a numerical value; it requires a comprehensive look at API purity, synthesis methods, and global supply chain stability. As a specialized anabolic steroid derivative, the cost is heavily influenced by the quality of raw materials and the rigor of the laboratory testing involved in the production process. This article explores the economic and technical variables that dictate market pricing for this specific compound. In the context of the global API market, pricing volatility is often tied to regulatory shifts in key manufacturing hubs
Nov 04, 26
How to Select High Purity Alisol C CAS 30489271 for Laboratory Research
High Purity Alisol C CAS 30489271 is suited to laboratories using Alisol C as a triterpenoid reference standard in metabolic, hepatology, pharmacology, HPLC/MS, botanical-extract, or selected cell-line research. We explain the application fit and the identity, purity, physical form, solvent, endotoxin, storage, quantity, and batch-record checks to make before ordering.
Nov 02, 26
Reliable Oxandrolone Supplier for High Purity Pharmaceutical APIs
When sourcing high-purity pharmaceutical ingredients for endocrine or cardiovascular research, the reliability of the supply chain is as critical as the chemical purity itself. For laboratories and manufacturers seeking a dependable oxandrolone supplier, the focus must extend beyond simple certificates of analysis to encompass consistent batch-to-batch stability and strict adherence to GMP standards. Whether the requirement is for small-scale pilot studies or large-scale industrial production, the ability to trace materials from raw synthesis to final lyophilized powder ensures the integrity of the resulting clinical or research data.