![[Lys0] – γ – 1 – MSH (41 – 58), amide](https://images.cnmqh.com/images/a10134/4f9d02eb31c80f1020cacfbe5fcc5cb5-20260129071334.webp "[Lys0] – γ – 1 – MSH (41 – 58), amide")
[Lys0] – γ – 1 – MSH (41 – 58), amide
[Lys0] – γ – 1 – MSH (41 – 58), amide
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Lys0] - γ - 1 - MSH (41 - 58), amide |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C80H112N24O16S |
| Molecular Weight | 1698g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, physiological saline, or dilute acetic acid solution. It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 1-5 mg/mL stock solution, then dilute to the working concentration with assay buffer. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | This peptide is an analog of γ₁-Melanocyte-Stimulating Hormone, expected to act as a ligand for melanocortin receptors (e.g., MC3R, MC5R). Biological activity should be confirmed through relevant functional assays such as cAMP accumulation in cells expressing target melanocortin receptors. |
| Storage Conditions | Lyophilized powder: Store desiccated at -20°C or below, protected from light, for long-term stability. Reconstituted solution: Aliquot and store at ≤-20°C. Avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The mechanism of action involves binding to melanocortin receptors, primarily MC3R and potentially other receptor subtypes, acting as a ligand that may modulate receptor signaling. The N-terminal lysine addition (Lys⁰) is a structural modification designed to potentially influence receptor interaction, possibly affecting binding affinity, selectivity, or metabolic stability compared to the native γ₁-MSH sequence. Upon receptor engagement, the peptide is expected to trigger intracellular signaling cascades, potentially leading to cAMP accumulation through Gαs protein coupling, similar to other melanocortin peptides, although the specific pharmacological profile and receptor selectivity of this modified analog may differ from the endogenous ligand and require experimental characterization.
2.PRODUCT INDICATIONS
This γ₁-MSH analog is indicated for research use only in preclinical studies investigating melanocortin receptor biology, structure-activity relationships of melanocortin peptides, and the effects of N-terminal modifications on peptide function. It serves as a tool compound in receptor binding assays, functional assays measuring second messenger production, and comparative studies with other melanocortin analogs to understand how specific amino acid modifications influence receptor interaction and biological activity. The product is also used in metabolic regulation research and studies exploring the development of modified peptide therapeutics targeting melanocortin pathways. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, [Lys⁰]-γ₁-MSH (41-58), amide does not have established clinical efficacy for therapeutic use in human patients. This specific peptide analog has not undergone clinical development or received regulatory approval for any medical indication. While γ₁-MSH and related melanocortin peptides have been studied in preclinical models to understand their physiological roles, this particular modified analog remains an investigational research tool used primarily for structure-activity relationship studies and basic research purposes. It has no proven clinical efficacy or safety profile for human use and is intended solely for laboratory research applications.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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