Nesiritide Acetate （BNP-32） CAS NO.114471-18-0
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Nesiritide Acetate （BNP-32） |
| CAS NO. | 114471-18-0 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C143H244N50O42S4 |
| Molecular Weight | 3464.04 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water or 0.9% Sodium Chloride Injection; insoluble in organic solvents |
| Endotoxin | < 5 EU/mg |
| Biological Activity | Exhibits potent vasodilatory and natriuretic effects via activation of NPR-A receptor; used for acute decompensated heart failure |
| Storage Conditions | Store at 2-8°C (refrigerated), protected from light; avoid freezing |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Nesiritide exerts its effects by binding to guanylyl cyclase-coupled natriuretic peptide receptors (primarily NPR-A) on vascular smooth muscle and endothelial cells. This binding triggers a signaling cascade that elevates intracellular cyclic GMP (cGMP), leading to smooth muscle relaxation and subsequent dilation of arteries and veins. Beyond vasodilation, it promotes renal natriuresis and diuresis by enhancing glomerular filtration and inhibiting sodium reabsorption, while simultaneously counteracting the maladaptive neurohormonal activation seen in heart failure by suppressing renin-angiotensin-aldosterone system activity.
2.PRODUCT INDICATIONS
This product is clinically indicated for the intravenous treatment of patients hospitalized with acutely decompensated congestive heart failure (ADHF), particularly those experiencing dyspnea at rest or with minimal activity. It is targeted at individuals requiring rapid reduction of cardiac preload and afterload, and is intended to be used as part of a comprehensive inpatient regimen alongside diuretics and other standard therapies, typically for short-term management not exceeding a few days.
3.CLINICAL EFFICACY OF PRODUCT
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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