Name: α-MSHa Synthetic Tripeptide Agonist for Melanocortin Research
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α‑Melanocyte Stimulating Hormone [Acetyl‑D‑Lys¹¹, D‑Val¹³] (11‑13) (MSHa)

α-Melanocyte Stimulating Hormone [Acetyl-D-Lys¹¹, D-Val¹³] (11-13) (MSHa) is a truncated and modified fragment of α-MSH, with no unique CAS number. Possessing a molecular formula of C₁₈H₃₃N₅O₄ and a molecular weight of 383.49 g/mol, this synthetic tripeptide features a modified amino acid sequence (Ac‑D‑Lys‑Pro‑D‑Val‑OH) that enhances its stability while retaining core melanocortin signaling activity. As a selective agonist of melanocortin receptors (MC1R/MC4R), it exerts key physiological functions including melanin synthesis modulation and energy metabolism regulation. Our MSHa is manufactured under strict quality control standards, ensuring ≥98% purity (RP-HPLC), low endotoxin levels, and consistent biological activity, making it an ideal tool for scientific research, pharmaceutical R&D, and melanocortin receptor-related studies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	α‑Melanocyte Stimulating Hormone [Acetyl‑D‑Lys¹¹, D‑Val¹³] (11‑13) (MSHa)
CAS NO.	\
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₈H₃₃N₅O₄
Molecular Weight	g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥1 mg/mL), PBS buffer (pH 7.2–7.4), and DMSO; slightly soluble in methanol/ethanol
Endotoxin	< 1.0 EU/mg
Biological Activity	Selective melanocortin receptor (MC1R/MC4R) agonist; modulates melanin synthesis and energy metabolism; retains core MSH signaling activity with enhanced stability
Storage Conditions	-20°C for long‑term storage (stable for 2 years); avoid repeated freeze‑thaw cycles; store desiccated
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The biological activity of MSHa is primarily mediated through its high-affinity and selective binding to melanocortin receptors (MC1R and MC4R), a subset of G-protein-coupled receptors (GPCRs). Its modified amino acid structure (Acetyl-D-Lys¹¹ and D-Val¹³) enhances binding affinity to target receptors and improves in vitro/in vivo stability compared to native α-MSH fragments. Upon binding to MC1R on melanocytes, MSHa activates the cAMP/PKA signaling pathway, which phosphorylates the microphthalmia-associated transcription factor (MITF), upregulating tyrosinase expression and promoting melanin synthesis.

2.PRODUCT INDICATIONS

Melanocortin receptor research: Exploration of MC1R/MC4R structure-function relationships, serving as a standard ligand for receptor activation assays and agonist/antagonist screening.

Skin pigmentation research: Investigation of melanin synthesis mechanisms, development of tools for studying hypopigmentation and hyperpigmentation disorders.

Metabolic research: Study of MC4R-mediated energy metabolism and appetite regulation pathways, supporting anti-obesity and metabolic syndrome drug development.

3.CLINICAL EFFICACY OF PRODUCT

MSHa is currently in preclinical research stages, with promising efficacy demonstrated in in vitro and in vivo models focusing on melanocortin receptor-related pathways. In cell-based assays, it has shown significant selective activation of MC1R and MC4R, with enhanced stability compared to unmodified α-MSH fragments—providing a valuable tool for optimizing peptide-based drug candidates.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.