L- glutamic acid -5- tert-butyl ester CAS NO.2419-56-9

L- glutamic acid -5- tert-butyl ester CAS NO.2419-56-9

L- glutamic acid -5- tert-butyl ester CAS-NO.:2419-56-9 belongs to the protected derivative of mono-tert-butyl ester of L-glutamic acid. In chemical structure, the 5-carboxyl group (distal carboxyl group) of L-glutamic acid is protected by tert-butoxy group (-O-tBu), and the 2-carboxyl group (α-carboxyl group) and amino group remain free. The configuration is L-shaped ((2S)- configuration), the corresponding SMILES expression is CC (C)(C) OC (=O) CCC@HC (O)=O, and the core skeleton is a five-carbon chain containing amino group, free carboxyl group and tert-butyl ester protected carboxyl group, which is a typical carboxyl-protected amino acid.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	L-Glutamic acid 5-tert-butyl ester
CAS NO.	2419-56-9
Appearance	White to off-white crystalline powder
Molecular Formula	C₉H₁₇NO₄
Molecular Weight	203.24 g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in methanol, ethanol, and dimethyl sulfoxide (DMSO); slightly soluble in water
Endotoxin	< 1.0 EU/mg
Biological Activity	This product is a protected amino acid derivative, primarily used as a building block in peptide synthesis.
Storage Conditions	Store in a cool, dry place at 2–8°C, protected from light and moisture. For long-term storage, store at -20°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

As a protected amino acid building block, L-Glutamic Acid 5-tert-Butyl Ester functions as a key synthetic intermediate rather than possessing direct biological activity. Its chemical mechanism involves selective protection/deprotection chemistry during peptide synthesis: the tert-butyl ester group protects the γ-carboxyl side chain of glutamic acid from unwanted reactions during peptide chain elongation, while allowing the α-carboxyl and α-amino groups to participate in standard peptide coupling reactions.

2.PRODUCT INDICATIONS

Peptide Pharmaceutical Synthesis – Essential building block for incorporating glutamic acid residues in therapeutic peptides and APIs.

Bioconjugate Chemistry – Key intermediate for designing drug-delivery systems and protein conjugates.

Enzyme Inhibitor Development – Used in synthesizing glutamic acid-containing enzyme substrates and inhibitors.

Neuroscience Research – Intermediate for neuroactive peptides and neurotransmitter analogs.

Structural Biology Studies – Building block for peptides used in protein folding and structure-function research.

3.CLINICAL EFFICACY OF PRODUCT

While L-Glutamic Acid 5-tert-Butyl Ester itself has no direct clinical efficacy, peptides synthesized using this protected amino acid demonstrate significant therapeutic potential. Glutamic acid residues play crucial roles in numerous therapeutic peptides: as catalytic sites in enzyme inhibitors, as metal-binding ligands in diagnostic agents, as hydrophilic components improving peptide solubility, and as critical residues in hormone analogs and receptor ligands.

4.DELIVERY & SHIPPING

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Shipping Methods
Main Method: International Air Freight

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