Name: L-Glutamic Acid-5-tert-Butyl Ester – High Purity & Stability
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L- glutamic acid -5- tert-butyl ester CAS NO.2419-56-9

L- glutamic acid -5- tert-butyl ester CAS NO.2419-56-9

L- glutamic acid -5- tert-butyl ester CAS-NO.:2419-56-9 belongs to the protected derivative of mono-tert-butyl ester of L-glutamic acid. In chemical structure, the 5-carboxyl group (distal carboxyl group) of L-glutamic acid is protected by tert-butoxy group (-O-tBu), and the 2-carboxyl group (α-carboxyl group) and amino group remain free. The configuration is L-shaped ((2S)- configuration), the corresponding SMILES expression is CC (C)(C) OC (=O) CCC@HC (O)=O, and the core skeleton is a five-carbon chain containing amino group, free carboxyl group and tert-butyl ester protected carboxyl group, which is a typical carboxyl-protected amino acid.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	L-Glutamic acid 5-tert-butyl ester
CAS NO.	2419-56-9
Appearance	White to off-white crystalline powder
Molecular Formula	C₉H₁₇NO₄
Molecular Weight	203.24 g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in methanol, ethanol, and dimethyl sulfoxide (DMSO); slightly soluble in water
Endotoxin	< 1.0 EU/mg
Biological Activity	This product is a protected amino acid derivative, primarily used as a building block in peptide synthesis.
Storage Conditions	Store in a cool, dry place at 2–8°C, protected from light and moisture. For long-term storage, store at -20°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

As a protected amino acid building block, L-Glutamic Acid 5-tert-Butyl Ester functions as a key synthetic intermediate rather than possessing direct biological activity. Its chemical mechanism involves selective protection/deprotection chemistry during peptide synthesis: the tert-butyl ester group protects the γ-carboxyl side chain of glutamic acid from unwanted reactions during peptide chain elongation, while allowing the α-carboxyl and α-amino groups to participate in standard peptide coupling reactions.

2.PRODUCT INDICATIONS

Peptide Pharmaceutical Synthesis – Essential building block for incorporating glutamic acid residues in therapeutic peptides and APIs.

Bioconjugate Chemistry – Key intermediate for designing drug-delivery systems and protein conjugates.

Enzyme Inhibitor Development – Used in synthesizing glutamic acid-containing enzyme substrates and inhibitors.

Neuroscience Research – Intermediate for neuroactive peptides and neurotransmitter analogs.

Structural Biology Studies – Building block for peptides used in protein folding and structure-function research.

3.CLINICAL EFFICACY OF PRODUCT

While L-Glutamic Acid 5-tert-Butyl Ester itself has no direct clinical efficacy, peptides synthesized using this protected amino acid demonstrate significant therapeutic potential. Glutamic acid residues play crucial roles in numerous therapeutic peptides: as catalytic sites in enzyme inhibitors, as metal-binding ligands in diagnostic agents, as hydrophilic components improving peptide solubility, and as critical residues in hormone analogs and receptor ligands.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.

Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.