Dermaseptin CAS NO.136212-91-4
Dermaseptin CAS NO.136212-91-4
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Dermaseptin |
| CAS NO. | 136212-91-4 |
| Appearance | White to off-white powder |
| Molecular Formula | C152H257N43O44S2 |
| Molecular Weight | 3455.52 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water (1–10 mg/mL), DMSO (<5 mg=""> |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Anti-Inflammatory Effect: Suppresses the release of pro-inflammatory cytokines. Antiviral Potential: Exhibits inhibitory effects on certain enveloped viruses (e.g., HIV) |
| Storage Conditions | Store at -20°C in a dry, dark place. Avoid repeated freeze-thaw cycles. Protect from moisture. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Membrane Disruption: Binds to microbial cell membranes via electrostatic interactions (targeting negatively charged phospholipids), forming pores that disrupt membrane integrity and induce leakage of intracellular contents.
Apoptosis Induction: Triggers mitochondrial dysfunction, reactive oxygen species (ROS) overproduction, and caspase activation in target cells (e.g., cancer cells or infected host cells).
Anti-inflammatory Effects: Inhibits pro-inflammatory cytokines (e.g., TNF-α, IL-6) and chemokines, reducing excessive immune responses.
2.PRODUCT INDICATIONS
Infectious Diseases: Bacterial infections (Gram-positive: Staphylococcus aureus; Gram-negative: Escherichia coli), fungal infections (Candida albicans), and viral infections (enveloped viruses like HIV-1).
Inflammatory Disorders: Chronic inflammatory conditions (e.g., dermatitis, colitis) due to its cytokine-modulating properties.
Cancer Therapy: Adjunctive treatment for solid tumors (e.g., lung, cervical cancer) via selective cytotoxicity against malignant cells.
3.CLINICAL EFFICACY OF PRODUCT
Antimicrobial Activity: Minimum inhibitory concentrations (MICs) range from 0.5–8 μg/mL against multidrug-resistant bacteria, outperforming conventional antibiotics in some cases.
Tumor Suppression: In vitro studies show IC₅₀ values of 1–10 μM against HeLa, A549, and MCF-7 cancer cell lines, with minimal toxicity to normal cells.
Wound Healing: Topical application accelerates tissue repair in animal models of skin injury by reducing infection and inflammation.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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