Name: Dermaseptin Peptide CAS 136212-91-4 | Potent Antimicrobial
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Dermaseptin CAS NO.136212-91-4

Dermaseptin (CAS No. 136212-91-4) is a naturally derived antimicrobial peptide with broad-spectrum bioactivity, widely studied for its therapeutic potential in infectious diseases and inflammatory conditions. Its molecular formula is C152H257N43O44S2, and molecular weight is 2445.8 g/mol. As a key member of amphibian-derived peptides, Dermaseptin combines potent antimicrobial action with low cytotoxicity, making it a promising candidate for drug development and biomedical applications.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Dermaseptin
CAS NO.	136212-91-4
Appearance	White to off-white powder
Molecular Formula	C152H257N43O44S2
Molecular Weight	3455.52 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water (1–10 mg/mL), DMSO (<5 mg="">
Endotoxin	< 1.0 EU/mg
Biological Activity	Anti-Inflammatory Effect: Suppresses the release of pro-inflammatory cytokines. Antiviral Potential: Exhibits inhibitory effects on certain enveloped viruses (e.g., HIV)
Storage Conditions	Store at -20°C in a dry, dark place. Avoid repeated freeze-thaw cycles. Protect from moisture.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Membrane Disruption: Binds to microbial cell membranes via electrostatic interactions (targeting negatively charged phospholipids), forming pores that disrupt membrane integrity and induce leakage of intracellular contents.

Apoptosis Induction: Triggers mitochondrial dysfunction, reactive oxygen species (ROS) overproduction, and caspase activation in target cells (e.g., cancer cells or infected host cells).

Anti-inflammatory Effects: Inhibits pro-inflammatory cytokines (e.g., TNF-α, IL-6) and chemokines, reducing excessive immune responses.

2.PRODUCT INDICATIONS

Infectious Diseases: Bacterial infections (Gram-positive: Staphylococcus aureus; Gram-negative: Escherichia coli), fungal infections (Candida albicans), and viral infections (enveloped viruses like HIV-1).

Inflammatory Disorders: Chronic inflammatory conditions (e.g., dermatitis, colitis) due to its cytokine-modulating properties.

Cancer Therapy: Adjunctive treatment for solid tumors (e.g., lung, cervical cancer) via selective cytotoxicity against malignant cells.

3.CLINICAL EFFICACY OF PRODUCT

Antimicrobial Activity: Minimum inhibitory concentrations (MICs) range from 0.5–8 μg/mL against multidrug-resistant bacteria, outperforming conventional antibiotics in some cases.

Tumor Suppression: In vitro studies show IC₅₀ values of 1–10 μM against HeLa, A549, and MCF-7 cancer cell lines, with minimal toxicity to normal cells.

Wound Healing: Topical application accelerates tissue repair in animal models of skin injury by reducing infection and inflammation.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.