[Phe1376] – Fibronectin Fragment (1371 – 1382) CAS NO.174063-90-2

[Phe1376] – Fibronectin Fragment (1371-1382) is a high-purity synthetic peptide fragment derived from a key functional domain of human fibronectin. This bioactive peptide is designed to mimic native fibronectin’s cell-interactive region, supporting advanced research in cell adhesion, migration, and extracellular matrix signaling. Manufactured under strict quality controls and supplied as a white to off-white lyophilized powder, it ensures reliable performance in experimental studies. The peptide is ideal for researchers exploring fibronectin-integrin interactions, tissue remodeling, and disease mechanisms in preclinical and cellular models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Phe1376] – Fibronectin Fragment (1371-1382)
CAS NO.	174063-90-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C63H103N25O19
Molecular Weight	1514.68 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, PBS (pH 7.0-7.5), dilute acetic acid
Endotoxin	< 1.0 EU/mg
Biological Activity	Fibronectin functional fragments; involved in cell adhesion, signal transduction, and cell-matrix interactions; commonly used in integrin binding studies, cell migration experiments, and tissue engineering applications.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[Phe1376] – Fibronectin Fragment (1371-1382) binds selectively to integrin receptors, particularly α5β1 and αvβ3, on cell surfaces. This binding initiates intracellular signaling cascades involving focal adhesion kinase (FAK) and downstream pathways, regulating cell adhesion, spreading, migration, and survival. The Phe1376 residue plays a critical role in stabilizing receptor engagement, making this peptide a potent modulator of cell–matrix interactions in experimental settings.

2.PRODUCT INDICATIONS

Cell Adhesion & Migration Studies: In vitro and ex vivo assays for fibronectin-dependent cellular behaviors
Integrin Signaling Research: Investigation of α5β1- and αvβ3-mediated signaling in normal and pathological states
Tissue Engineering: Functionalization of biomaterials to enhance cell attachment and tissue integration
Cancer Metastasis Models: Study of tumor cell invasion, extravasation, and metastatic niche formation
Drug Discovery: Screening for anti-adhesive or pro-adhesive therapeutics targeting fibronectin–integrin interactions

3.CLINICAL EFFICACY OF PRODUCT

Validated Bioactivity: Demonstrated functional activity in cell adhesion assays, migration studies, and integrin binding experiments
High Purity: ≥95% HPLC purity with mass spectrometry confirmation of sequence and molecular weight
Reproducible Results: Batch-to-batch consistency supported by comprehensive Certificates of Analysis (CoA)
Research Versatility: Suitable for coating surfaces, competitive inhibition studies, and signal transduction analysis
Translational Relevance: Enables modeling of fibronectin-related pathologies such as fibrosis, cancer, and impaired wound healing
Quality Assurance: Manufactured under GLP-like conditions with low endotoxin levels for in vitro and preclinical use

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.