![[Phe1376] – Fibronectin Fragment (1371 – 1382) CAS NO.174063-90-2](https://images.cnmqh.com/images/a10134/bae996d4384ee2efda9d7bded4b7b3ac-20260123092212.webp "[Phe1376] – Fibronectin Fragment (1371 – 1382) CAS NO.174063-90-2")
[Phe1376] – Fibronectin Fragment (1371 – 1382) CAS NO.174063-90-2
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Phe1376] – Fibronectin Fragment (1371-1382) |
| CAS NO. | 174063-90-2 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C63H103N25O19 |
| Molecular Weight | 1514.68 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, PBS (pH 7.0-7.5), dilute acetic acid |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Fibronectin functional fragments; involved in cell adhesion, signal transduction, and cell-matrix interactions; commonly used in integrin binding studies, cell migration experiments, and tissue engineering applications. |
| Storage Conditions | Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
[Phe1376] – Fibronectin Fragment (1371-1382) binds selectively to integrin receptors, particularly α5β1 and αvβ3, on cell surfaces. This binding initiates intracellular signaling cascades involving focal adhesion kinase (FAK) and downstream pathways, regulating cell adhesion, spreading, migration, and survival. The Phe1376 residue plays a critical role in stabilizing receptor engagement, making this peptide a potent modulator of cell–matrix interactions in experimental settings.
2.PRODUCT INDICATIONS
- Cell Adhesion & Migration Studies: In vitro and ex vivo assays for fibronectin-dependent cellular behaviors
- Integrin Signaling Research: Investigation of α5β1- and αvβ3-mediated signaling in normal and pathological states
- Tissue Engineering: Functionalization of biomaterials to enhance cell attachment and tissue integration
- Cancer Metastasis Models: Study of tumor cell invasion, extravasation, and metastatic niche formation
- Drug Discovery: Screening for anti-adhesive or pro-adhesive therapeutics targeting fibronectin–integrin interactions
3.CLINICAL EFFICACY OF PRODUCT
- Validated Bioactivity: Demonstrated functional activity in cell adhesion assays, migration studies, and integrin binding experiments
- High Purity: ≥95% HPLC purity with mass spectrometry confirmation of sequence and molecular weight
- Reproducible Results: Batch-to-batch consistency supported by comprehensive Certificates of Analysis (CoA)
- Research Versatility: Suitable for coating surfaces, competitive inhibition studies, and signal transduction analysis
- Translational Relevance: Enables modeling of fibronectin-related pathologies such as fibrosis, cancer, and impaired wound healing
- Quality Assurance: Manufactured under GLP-like conditions with low endotoxin levels for in vitro and preclinical use
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
