Gastrin Releasing Peptide, procine CAS NO.74815-57-9

Gastrin Releasing Peptide, Porcine (CAS: 74815-57-9), commonly referred to as GRP(porcine) or GRP-27, is a 27-amino acid neuropeptide originally isolated from porcine gastric tissue. This bioactive peptide shares high sequence homology with its human counterpart (GRP) and the C-terminal fragment bombesin. It functions as a potent regulator of gastrointestinal hormone secretion, particularly stimulating the release of gastrin from G-cells.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Gastrin Releasing Peptide, Porcine (pGRP)
CAS NO.	74815-57-9
Appearance	White to off-white lyophilized powder
Molecular Formula	C126H198N38O31S2
Molecular Weight	2805.4 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥ 10 mg/mL), dilute acetic acid, or DMSO; clear solution at 1 mg/mL in water
Endotoxin	< 1.0 EU/mg
Biological Activity	Stimulates gastrin release from G cells in the stomach Potent mitogen for gastrointestinal tract and lung cancer cells
Storage Conditions	Store at -20°C to -80°C in a desiccated environment Avoid repeated freeze-thaw cycles; aliquot for long-term storage
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GRP(porcine) exerts its biological effects by binding and activating the Gastrin-Releasing Peptide Receptor (GRPR), a G protein-coupled receptor (GPCR) predominantly of the Gq/11 subtype. Upon ligand binding, the receptor activates phospholipase C (PLC), leading to the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP₂) into inositol trisphosphate (IP₃) and diacylglycerol (DAG). IP₃ triggers the release of calcium from intracellular stores, while DAG activates protein kinase C (PKC).

2.PRODUCT INDICATIONS

Gastrointestinal Physiology Studies: Investigating the regulation of gastric acid secretion, gastrin release, and gastrointestinal motility.

GRP Receptor (GRPR) Research: Serving as a native ligand in receptor binding assays, autoradiography, and signal transduction studies.

Cancer Research: Exploring the role of GRP/GRPR signaling in the proliferation of certain cancer cell lines (e.g., small cell lung cancer, prostate cancer).

Neuroscience Applications: Studying the role of GRP as a neuromodulator in the central nervous system, particularly in behaviors like satiety and stress response.

Smooth Muscle Function Assays: Evaluating its contractile effects on gastrointestinal and bronchial smooth muscle preparations.

Diagnostic Development: Potential use in the development of assays to measure gastrin secretory capacity or GRPR expression

3.CLINICAL EFFICACY OF PRODUCT

Diagnostic Utility: In clinical research settings, synthetic human GRP (or its stable analogs) has been used in gastric function tests (e.g., the GRP stimulation test) to assess gastrinoma or evaluate gastrin secretory capacity, though its use is specialized.

Therapeutic Targeting: The GRP/GRPR system is a recognized target in oncology. GRPR antagonists are being investigated in clinical trials for cancer imaging and therapy, particularly for prostate and breast cancers. For example, radiolabeled GRPR antagonists are used in PET imaging to detect tumors.

Preclinical Evidence: Extensive animal and in vitrostudies using porcine GRP have elucidated its role in stimulating gastrin release, gastric acid secretion, and cellular proliferation, forming the basis for understanding its pathophysiological roles.

No direct clinical efficacy data exists for porcine GRP as a drug. Its value lies in its application in basic and translational research that informs drug discovery and diagnostic development targeting the GRP pathway.

4.DELIVERY & SHIPPING

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