[Des-octanoyl]-Ghrelin, rat CAS NO.307950-60-3

[Des-octanoyl]-Ghrelin, rat is a modified 28-amino acid peptide analog of rat ghrelin, engineered to lack the critical octanoyl (acyl) group normally attached to the serine-3 residue. This "unacylated" or "des-acyl" form circulates naturally in the bloodstream in higher concentrations than its acylated counterpart. Supplied as a high-purity lyophilized powder, it exhibits distinct biological properties and receptor interactions compared to acylated ghrelin.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Des-octanoyl]-Ghrelin, rat
CAS NO.	307950-60-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C139H231N45O41
Molecular Weight	3188.67g/mol
Purity (RP-HPLC)	≥98.0%
Solubility	Soluble in water (≥5 mg/mL), dilute acetic acid, and DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	A non-acylated form of ghrelin; exhibits reduced affinity for the ghrelin receptor (GHSR-1a) but retains some modulatory effects on appetite and energy metabolism.
Storage Conditions	Store at -20°C to -80°C in a sealed container, protected from moisture and light.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[Des-octanoyl]-Ghrelin functions as a ligand for an alternative, high-affinity receptor distinct from the canonical Growth Hormone Secretagogue Receptor 1a (GHSR1a). Unlike acylated ghrelin, it does not activate GHSR1a, which mediates growth hormone release and orexigenic effects. Instead, it is believed to bind to a specific, yet not fully characterized, "unacylated ghrelin receptor" or modulate receptor complexes involving GHSR1a, triggering unique intracellular signaling cascades.

2.PRODUCT INDICATIONS

Control in Ghrelin Studies: Serving as an essential negative control in experiments to differentiate the specific effects mediated by GHSR1a activation (via acylated ghrelin) from those mediated by alternative receptors or non-specific mechanisms.

Metabolic Research: Investigating its unique role in glucose homeostasis, insulin sensitivity, and lipid metabolism in rat models of diabetes or obesity.

Cardiovascular Physiology: Studying its potential protective effects on the heart (e.g., ischemia-reperfusion injury) and vasculature in preclinical rat models.

Non-Canonical Signaling Studies: Exploring its distinct signaling pathways in tissues where its effects oppose those of acylated ghrelin, such as in adipocytes or pancreatic cells.

Receptor Pharmacology: Aiding in the identification and characterization of the putative high-affinity receptor for unacylated ghrelin.

3.CLINICAL EFFICACY OF PRODUCT

Preclinical Evidence in Rodents: Studies in rats demonstrate that unacylated ghrelin has biological activity, influencing metabolic parameters and exerting cardioprotective effects, despite being devoid of GH-releasing or appetite-stimulating activity.

Human Relevance & Therapeutic Potential: Research in humans indicates that circulating unacylated ghrelin has beneficial metabolic effects, such as improving insulin sensitivity and beta-cell survival. It is being investigated as a potential therapeutic candidate for metabolic syndrome and cardiovascular diseases due to its favorable profile (e.g., no stimulation of appetite).

Current Status: The rat peptide itself is not a clinical drug. Its use is confined to preclinical research that validates the target and biological effects, which may inform the development of human therapeutics based on the unacylated ghrelin molecule or mimetics.

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
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Shipping Methods
Main Method: International Air Freight

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